Results 61 to 70 of about 9,742,950 (352)
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Vìsnik Odesʹkogo Nacìonalʹnogo Unìversitetu: Bìblìotekoznavstvo, Bìblìografoznavstvo, Knigoznavstvo, 2016 The purpose of our article is consideration of questions of electronic subject analysis of documents and methodical ensuring editing subject headings in the electronic catalog.
Т. М. Бикова
doaj
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Molecular Oncology, Volume 19, Issue 12, Page 3518-3534, December 2025.There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes +20 more
wiley +1 more source
Molecular Oncology, Volume 19, Issue 12, Page 3613-3633, December 2025.This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu +12 more
wiley +1 more source
Sphere of Subject of Regional Documents of 18th Century: Dynamical Aspect
Научный диалог, 2017 The results of a comparative analysis of ways of representation the text subject sphere in the documents on a single genre are presented. The research materials are the military charters of the middle and the end of the 18th century, which are kept in ...
E. M. Sheptukhina
doaj
Definitions, 2020 This report documents the program and the outcomes of Dagstuhl Seminar 23062 “Programming Language Processing” (PLP). The seminar brought together researchers and practitioners from three communities–software engineering, programming languages, and ...
Jiewen Yao, Vincent Zimmer
semanticscholar +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source