Results 51 to 60 of about 73,106 (263)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

ЭЛЕКТРОННЫЙ МЕТОДИЧЕСКИЙ АППАРАТ ПРЕДМЕТИЗАТОРА В ГПНТБ СО РАН

open access: yesБиблиосфера, 2010
The formation of rules and methodical instrument for a subject cataloger began in SPSTL SB RAS in 2007. The authors describe the structure, functions and technology of operating the electronic file of methodical decisions on subject cataloging.

doaj  

Enhancing an Open-Access Linguistics Journal Archive with Library of Congress-like Metadata: A Case Study of the Effectiveness for Improving Discovery

open access: yesKansas Working Papers in Linguistics, 2014
The University of Kansas has hosted the Kansas Working Papers in Linguistic (KWPL) in its digital repository, KU ScholarWorks, since 2007, but complete subject metadata, based on Library of Congress Subject Headings, was added only in 2013.
Husic, Geoff
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

open access: yesMolecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon   +4 more
wiley   +1 more source

Subject headings lists ahd thesaurus initiatives for equity and social justice.

open access: yesAnales de Documentación
The research aimed to describe initiatives for creating and updating subject heading lists and thesaurus considering social justice and equity, based on the literature from the sociocultural dimension of Knowledge Organization.
Fabíola Rubim Silva   +1 more
doaj   +1 more source

Las razas en una lista de encabezamientos de materia en español Races in a subject heading list in Spanish

open access: yesCiência da Informação, 2006
Se analizaron en la Lista de encabezamientos de materia para biblioteca (LEMB) los epígrafes referidos a raza, según criterios de otredad, confinamiento, omisión, estructura inadecuada y terminología tendenciosa.
Alicia J. Todaro, Ana M. Martínez
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Blind links, a big challenge in the linked data idea: Analysis of Persian Subject Headings

open access: yesIranian Journal of Information Processing & Management, 2014
In this survey, Linked data concept as exposing, sharing, and connecting pieces of data, information, and knowledge on the Semantic Web and some potential problems in converting Persian subject headings (PSHs) Records into linked data were discussed.
Atefeh Sharif
doaj  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

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