Results 51 to 60 of about 79,339 (252)

[18F]Fluorodeprenyl‐D2 PET as a Tool to Monitor Disease Activity in GAD65‐Ab Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate [18F]fluorodeprenyl‐D2 ([18F]F‐DED) positron‐emission tomography (PET) imaging as a biomarker of disease activity in autoimmune encephalitis (AIE) associated with glutamic acid decarboxylase 65 (GAD65) antibodies. Methods [18F]F‐DED PET was performed in 25 GAD65‐AIE patients and 8 controls using dynamic (0–60 min) and ...
Julia S. Dorneich, Jonathan A. Gernert, Hanna Zimmermann, Lisa Tagnin, Marianthi Zeinaki, Laura Sanzo, Letizia Vogler, Elisabeth Kaufmann, Justina Dargvainiene, Frank Leypoldt, Gérard N. Bischof, Robert Perneczky, Boris‐Stephan Rauchmann, Simon Lindner, Günter U. Höglinger, Rudolf A. Werner, Martin Kerschensteiner, Tania Kümpfel, Matthias Brendel, Franziska S. Thaler   +19 more
wiley   +1 more source

Digital Cognitive Phenotyping for Differential Diagnosis and Monitoring in Neurological Conditions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the utility, accessibility, and equivalence to supervised scales of online cognitive assessment in older individuals with cognitive impairment. Methods Patients with Alzheimer's disease (AD, n = 31), idiopathic normal pressure hydrocephalus (iNPH, n = 26), and traumatic brain injury (TBI, n = 23) completed online cognitive ...
Martina Del Giovane, Valentina Giunchiglia, Michael C. B. David, Magdalena A. Kolanko, William R. Trender, Peter J. Hellyer, Harmeena Kaur, David J. Sharp, Christopher Carswell, Paresh A. Malhotra, Adam Hampshire   +10 more
wiley   +1 more source

Digital Cognitive Testing in Mitochondrial Disease: Validity and Challenges for Clinical Trial Use

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Primary mitochondrial disease is a group of genetic disorders caused by pathogenic variants in nuclear or mitochondrial DNA, often resulting in progressive neurodegeneration and cognitive decline. Current management is primarily supportive, though recent research offers hope for disease‐modifying treatments in the future.
Oksana Pogoryelova, Jan Smeitink, Herma Renkema, Rosabeth White, Frankie Barton, Rachel Lyon, Jane Newman, Aye Moe, Yi Shiau Ng, Grainne Siobhan Gorman   +9 more
wiley   +1 more source

Psychometric Cognitive Decline Precedes the Advent of Subjective Cognitive Decline in the Evolution of Alzheimer’s Disease [PDF]

Dementia and Geriatric Cognitive Disorders, 2020
<b><i>Background:</i></b> We have described the clinical stages of the brain aging and Alzheimer’s disease (AD) continuum. In terms of the pre-dementia stages of AD, we introduced the terminology “mild cognitive impairment” (MCI) for the first pre-dementia stage and “subjective cognitive decline” (SCD) for the pre-MCI stage.
Barry, Reisberg, Yongzhao, Shao, Mesum, Moosavi, Sunnie, Kenowsky, Alok, Vedvyas, Karyn, Marsh, Jia, Bao, Maja, Buj, Carol, Torossian, Alan, Kluger, Gaurav, Vedvyas, Thet, Oo, Fawad, Malik, Fauzia, Arain, Arjun V, Masurkar, Thomas, Wisniewski   +15 more
openaire   +2 more sources

Factors Associated With the Rising Trend in Self‐Reported Cognitive Disability Among U.S. Adults Aged 18–39 From 2013–2024

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Building on our prior Behavioral Risk Factor Surveillance System analysis identifying adults aged 18–39 as the primary driver of the national increase in self‐reported cognitive disability, we examined factors associated with this rise using 2013–2024 U.S. BRFSS data. Methods We analyzed U.S.
Adam de Havenon, Ka‐Ho Wong, Mirriam Mananah, Christopher D. Anderson, Ada Fenick, Amy Arnsten, Arman Fesharaki‐Zadeh, James C. McPartland, Mary L. Adams, Kevin N. Sheth   +9 more
wiley   +1 more source

Progressive Parkinsonism in PPP2R5D‐Related Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT PPP2R5D‐related neurodevelopmental disorder (Houge–Janssens syndrome type 1) is a rare autosomal dominant condition characterized by macrocephaly, intellectual disability, and epilepsy. Progressive parkinsonism is an emerging adult phenotype that neurologists should be aware of since timely genetic diagnosis opens the door to disease‐modifying
Katerina Bernardi, Enrique Gonzalez Saez‐Diez, Joshua Rong, Beril Ay, Shabbir Merchant, Kathryn Yang, Darius Ebrahimi‐Fakhari   +6 more
wiley   +1 more source

The Association of Physical Function With Psychosocial Patient‐Reported Outcomes in People With Systemic Lupus Erythematosus

Arthritis Care &Research, EarlyView.
Objective To evaluate how modifiable psychosocial factors and fatigue relate to physical functioning in patients with systemic lupus erythematosus (SLE). Methods In this cross‐sectional study of two demographically distinct cohorts (Approaches to Positive, Patient‐Centered Experiences of Aging with Lupus [APPEAL] and California Lupus Epidemiology Study
Mrinalini Dey, Jessica Fitzpatrick, Maria Dall'Era, Charmayne Dunlop‐Thomas, Courtney Hoge, S. Sam Lim, Patricia P. Katz, Jinoos Yazdany, Laura C. Plantinga   +8 more
wiley   +1 more source

Cognitive Rehabilitation in Normal Aging and Individuals with Subjective Cognitive Decline [PDF]

, 2020
Aging-related changes include declines in especially episodic memory, working memory, processing speed, and executive functions. Cognitive rehabilitation programs for healthy older adults with subjective cognitive decline consist of brain training, strategy training, and multimodal interventions.
Eikelboom, W.S., Bertens, D., Kessels, R.P.C.   +2 more
openaire   +1 more source

Disentangling the relationship of subjective cognitive decline and depressive symptoms in the development of cognitive decline and dementia

Alzheimer's & Dementia, 2022
AbstractIntroductionSubjective cognitive decline (SCD) and depressive symptoms (DS) frequently co‐occur prior to dementia. However, the temporal sequence of their emergence and their combined prognostic value for cognitive decline and dementia is unclear.MethodsTemporal relationships of SCD, DS and memory decline were examined by latent difference ...
Kleineidam, Luca, Wagner, Michael, Luppa, Melanie, Röhr, Susanne, Pentzek, Michael, Wiese, Birgitt, Maier, Wolfgang, Scherer, Martin, Kornhuber, Johannes, Peters, Oliver, Frölich, Lutz, Wiltfang, Jens, Guski, Jannis, Lewczuk, Piotr, Hüll, Michael, Ramirez, Alfredo, Jessen, Frank, Riedel-Heller, Steffi G, Heser, Kathrin, Wolfsgruber, Steffen, Miebach, Lisa, Bickel, Horst, König, Hans-Helmut, Weyerer, Siegfried, Lühmann, Dagmar, Kaduszkiewicz, Hanna   +25 more
openaire   +6 more sources

Memory-related subjective cognitive symptoms in the adult population: prevalence and associated factors – results of the LIFE-Adult-Study

BMC Psychology, 2018
Background Subjectively perceived memory problems (memory-related Subjective Cognitive Symptoms/SCS) can be an indicator of a pre-prodromal or prodromal stage of a neurodegenerative disease such as Alzheimer’s disease.
Tobias Luck, Susanne Roehr, Francisca S. Rodriguez, Matthias L. Schroeter, A. Veronica Witte, Andreas Hinz, Anja Mehnert, Christoph Engel, Markus Loeffler, Joachim Thiery, Arno Villringer, Steffi G. Riedel-Heller   +11 more
doaj   +1 more source