Results 51 to 60 of about 1,898,806 (256)

Characterization of the Pharmacokinetics of Samidorphan in Healthy Volunteers: Absolute Bioavailability and the Effect of Food and Age

Drugs in R&D, 2019
Background and Objectives Samidorphan (SAM) is a novel μ-opioid receptor antagonist. We report clinical pharmacokinetic (PK) properties of SAM following different routes of administration, and the effects of food and age on the PK of SAM following oral ...
Vipul Kumar, Hong Lu, Marjie Hard, Lisa von Moltke   +3 more
doaj   +1 more source

Recombinant activated factor VIIa for severe postpartum hemorrhage in Africa: Evidence, appropriate use, and research priorities—A narrative review

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Postpartum hemorrhage (PPH) accounts for 30%–50% of maternal mortality in Africa and occurs in the context of pre‐existing anemia, limited blood product availability, delayed recognition, and constrained referral systems. Although bundle‐based care (E‐MOTIVE), early tranexamic acid (TXA), and uterotonics have substantially improved outcomes, a
Johnny Mahlangu, Haroun Rhemtula, Jarrod Zamparini, Lawrence Chauke   +3 more
wiley   +1 more source

Randomized Controlled Trial of sublingual versus rectal Misoprostol in the prevention of primary postpartum hemorrhage [PDF]

Al-Azhar International Medical Journal
Background: Over 25% of all maternal deaths, especially in low-income nations, are attributed to postpartum hemorrhage (PPH), in accordance with the World Health Organization(WHO).
doaj   +1 more source

System‐Local Axes and Metabolic Reprogramming From Health to Response in House Dust Mite‐Specific Subcutaneous Immunotherapy for Allergic Rhinitis

iMetaMed, EarlyView.
This study delineated nasal‐plasma metabolic reprogramming in house dust mite‐allergic rhinitis (HDM‐AR) and subcutaneous immunotherapy (SCIT) response, showing compartment‐specific signatures dominated by nasal lipid‐redox and plasma nucleotide‐NAD+ axes and across the HC–HDM‐AR–SCIT response continuum, dual‑compartment metabolites exhibited ...
Bixing Fang, Fei Pan, Yachun Li, Yimeng Wang, Ze Wang, Zhiheng Huang, Ming Chen, Yun Li, Mengli Huang, Cheng Guo, Chubo Xie, Lina Dong, Yadong Gao, Zhuohang Yu   +13 more
wiley   +1 more source

Application limits of sublingual drug administration. 2 [PDF]

, 2011
Thesis briefly summarizes knowledge on the sublingual route of drug administration and brings newer facts about the pharmaceutical sublingual preparations, as well as basic information on dextran and its pharmaceutical use.
Krupauerová, Lucie
core   +1 more source

Subchronic Exposure to Cannabis‐Based Nanoemulsions Induces Histopathological and Molecular Alterations in the Rat Submandibular Gland

Journal of Applied Toxicology, EarlyView.
ABSTRACT The increasing therapeutic incorporation of cannabis has expanded phytocannabinoid application, yet peripheral adverse effects like xerostomia raise concerns regarding emerging biotechnological formulations. This study evaluated the effects of cannabis‐based lipid nanoemulsions on the rat submandibular gland parenchyma.
Lorrany Avanci Bullo, Gabriel Carvalhal de Aguiar, Daniel Vitor Souza, Barbara dos Anjos Rosário, Flavia de Oliveira, Fernando Augusto Cintra Magalhaes, Nágila Maria Pontes Silva Ricardo, Edilberto Rocha Silveira, Dávila Zampieri, Milena de Barros Viana, Daniel Araki Ribeiro   +10 more
wiley   +1 more source

Single-dose fentanyl sublingual spray for breakthrough cancer pain

Clinical Pharmacology: Advances and Applications, 2013
Donald R Taylor Comprehensive Pain Care PC, Marietta, GA, USA Abstract: Breakthrough cancer pain (BTCP) is defined as a transient exacerbation of pain that arises in patients with otherwise controlled persistent pain. BTCP typically has a rapid onset and
Taylor DR
doaj  

Sublingual Zolpidem for MRI in Claustrophobic Patients: A Prospective, Non‐Randomized Noninferiority Study

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Claustrophobia during MRI may lead to examination interruption, motion artifacts, prolonged acquisition time, and reduced diagnostic quality, frequently requiring intravenous sedation to ensure successful examination completion and adequate image acquisition.
Beatriz Birelli do Nascimento, Fernando de Sá Del Fiol, Marcus Vinicius Birelli do Nascimento, Lucas Bueno de Oliveira, Samanta Aparecida Alves, Lucas do Nascimento Bernardes   +5 more
wiley   +1 more source

Trans‐Cervical Ultrasound Imaging of the Adult Palatine Tonsils

Journal of Medical Radiation Sciences, EarlyView.
Ultrasound imaging of the adult palatine tonsils using a trans‐cervical approach can be used to assess the tonsillar region for intratonsillar and peritonsillar abscesses. An understanding of the sonographic anatomy, technique and tonsillar pathology is required to perform and interpret imaging and inform patient management.
Michelle Fenech, Tristan Reddan
wiley   +1 more source

Head-Up Tilt Table Testing with Sublingual Isosorbide Dinitrate in the Diagnosis of Vasovagal Syncope in Children

Eurasian Journal of Medicine, 2019
Objective: To evaluate the effect of sublingual administration of ISDN on the results of the head-up tilt table test (HUTT) in children and adolescents with vasovagal syncope. Materials and Methods: The study group consisted of 30 children, each
Mehmet Karacan, Hasim Olgun, Naci Ceviz
doaj