Evaluation of effectiveness and safety of Subolesin anti-tick vaccine in Ugandan multi-site field trial [PDF]
npj VaccinesVaccines are the most effective and sustainable intervention to control ticks and tick-borne diseases (TBD). Using a personalized vaccine design based on regional tick genotypes, a Rhipicephalus appendiculatus Subolesin protective antigen was used in a ...
Fredrick Kabi +25 more
doaj +2 more sources
Fourteen anti-tick vaccine targets are variably conserved in cattle fever ticks [PDF]
Parasites & VectorsBackground Rhipicephalus (Boophilus) microplus causes significant cattle production losses worldwide because it transmits Babesia bovis and B. bigemina, the causative agents of bovine babesiosis.
Joseph D. Busch +18 more
doaj +2 more sources
Global Trends in Vaccine Research on Ehrlichia and Anaplasma: A Bibliometric Review [PDF]
MicroorganismsEhrlichia and Anaplasma are important tick-borne obligate intracellular bacteria that cause clinically and economically significant infections in humans and animals.
Swetha Madesh +2 more
doaj +2 more sources
Evolution of tick vaccinology [PDF]
ParasitologyTicks represent a major concern for society worldwide. Ticks are also difficult to control, and vaccines represent the most efficacious, safe, economically feasible and environmentally sustainable intervention.
José de la Fuente +2 more
doaj +2 more sources
Designing a multi-epitope construct using immuno-informatic tools to prepare a messenger RNA vaccine against Rhipicephalus microplus ticks [PDF]
Veterinary WorldBackground and Aim: Ticks are blood-feeding ectoparasites that transmit pathogens to animals and humans. One of the most important hard ticks in animals is Rhipicephalus microplus, which transmits Babesia and Anaplasma spp.
Ubaid Ullah +3 more
doaj +2 more sources
Haemaphysalis longicornis subolesin controls the infection and transmission of severe fever with thrombocytopenia syndrome virus [PDF]
npj VaccinesSevere fever with thrombocytopenia syndrome (SFTS) caused by the SFTS virus (SFTSV) is an emerging tick-borne disease with a high mortality rate. Haemaphysalis longicornis is the primary reservoir and vector of SFTSV.
Chuanfei Yuan +6 more
doaj +2 more sources
Changes in Serum Biomarkers of Oxidative Stress in Cattle Vaccinated with Tick Recombinant Antigens: A Pilot Study [PDF]
Vaccines, 2020 Tick vaccination is an environmentally friendly alternative for tick control, pathogen infection, and transmission. Tick vaccine protection is sometimes incomplete, which may be due to problems in the stability, conformation, and activity of antibodies ...
Marinela Contreras +6 more
doaj +2 more sources
Cross-species immunoprotective antigens (subolesin, ferritin 2 and P0) provide protection against Rhipicephalus sanguineus sensu lato [PDF]
Parasites & VectorsBackground Tick control is mostly hampered by the rise of acaricide-resistant tick populations. Significant efforts have focused on developing alternative control methods, including cross-species protective and/or cocktail-based anti-tick vaccines, to ...
Ismail Zeb +4 more
doaj +2 more sources
Modelling protein-protein interactions for the design of vaccine chimeric antigens with protective epitopes. [PDF]
PLoS ONETicks and tick-borne diseases are a growing burden worldwide and vaccines are effective control interventions. Vaccine formulations with tick antigens such as BM86/BM95 (BM) and Subolesin (SUB) have shown reduction in tick fitness and infestation in ...
Marinela Contreras +13 more
doaj +2 more sources
Akirin/Subolesin Regulatory Mechanisms at Host/Tick–Pathogen Interactions [PDF]
MicroLife, 2022 José de la Fuente +2 more
exaly +2 more sources