Results 11 to 20 of about 476 (134)

Functional Evolution of Subolesin/Akirin [PDF]

Frontiers in Physiology, 2018
The Subolesin/Akirin constitutes a good model for the study of functional evolution because these proteins have been conserved throughout the metazoan and play a role in the regulation of different biological processes.
Sara Artigas-Jerónimo, Margarita Villar, Alejandro Cabezas-Cruz, James J. Valdés, James J. Valdés, James J. Valdés, Agustín Estrada-Peña, Pilar Alberdi, José de la Fuente, José de la Fuente   +9 more
doaj   +14 more sources

Evidence of the role of tick subolesin in gene expression [PDF]

BMC Genomics, 2008
Background Subolesin is an evolutionary conserved protein that was discovered recently in Ixodes scapularis as a tick protective antigen and has a role in tick blood digestion, reproduction and development.
Blouin Edmour F, Galindo Ruth C, de la Lastra José, Canales Mario, Almazán Consuelo, Nijhof Ard M, Ayoubi Patricia, Naranjo Victoria, Maritz-Olivier Christine, de la Fuente José, Gortazar Christian, Jongejan Frans, Kocan Katherine M   +12 more
doaj   +10 more sources

Haemaphysalis longicornis subolesin controls the infection and transmission of severe fever with thrombocytopenia syndrome virus [PDF]

npj Vaccines
Severe fever with thrombocytopenia syndrome (SFTS) caused by the SFTS virus (SFTSV) is an emerging tick-borne disease with a high mortality rate. Haemaphysalis longicornis is the primary reservoir and vector of SFTSV.
Chuanfei Yuan, Yu Sun, Jingjing Chen, Qiong Xu, Xiang Zhou, Zhen Zou, Qianfeng Xia   +6 more
doaj   +5 more sources

Subolesin expression in response to pathogen infection in ticks [PDF]

BMC Immunology, 2010
Background Ticks (Acari: Ixodidae) are vectors of pathogens worldwide that cause diseases in humans and animals. Ticks and pathogens have co-evolved molecular mechanisms that contribute to their mutual development and survival.
La Barbera Giuseppa, Mani Rinosh, Nijhof Ard M, Villar Margarita, Blouin Edmour F, Almazán Consuelo, Galindo Ruth C, Kocan Katherine M, Scimeca Salvatore, Alongi Angela, Mitra Ruchira, Torina Alessandra, Zivkovic Zorica, Caracappa Santo, Jongejan Frans, de la Fuente José   +15 more
doaj   +10 more sources

Reciprocal regulation of NF-kB (Relish) and Subolesin in the tick vector, Ixodes scapularis. [PDF]

PLoS ONE, 2013
BackgroundTick Subolesin and its ortholog in insects and vertebrates, Akirin, have been suggested to play a role in the immune response through regulation of nuclear factor-kappa B (NF-kB)-dependent and independent gene expression via interaction with ...
Victoria Naranjo, Nieves Ayllón, José M Pérez de la Lastra, Ruth C Galindo, Katherine M Kocan, Edmour F Blouin, Ruchira Mitra, Pilar Alberdi, Margarita Villar, José de la Fuente   +9 more
doaj   +8 more sources

Subolesin gene structure and mRNA isoform diversity in South African R. microplus ticks: Relevance for understanding subolesin-based tick vaccines

Ticks and Tick-Borne Diseases
Designing a universal vaccine against ticks, capable of protecting a wide range of species, has long been an appealing goal. One antigen that has been proposed for a universal tick vaccine is Subolesin.
Elsje Christine Rabie, Christine Maritz-Olivier   +1 more
doaj   +4 more sources

Identification and comparative analysis of subolesin/akirin ortholog from Ornithodoros turicata ticks [PDF]

Parasites & Vectors, 2015
Background Subolesin is an evolutionary conserved molecule in diverse arthropod species that play an important role in the regulation of genes involved in immune responses, blood digestion, reproduction and development.
Hameeda Sultana, Unnati Patel, Daniel E Sonenshine, Girish Neelakanta   +3 more
doaj   +6 more sources

Evaluation of effectiveness and safety of Subolesin anti-tick vaccine in Ugandan multi-site field trial [PDF]

npj Vaccines
Vaccines are the most effective and sustainable intervention to control ticks and tick-borne diseases (TBD). Using a personalized vaccine design based on regional tick genotypes, a Rhipicephalus appendiculatus Subolesin protective antigen was used in a ...
Fredrick Kabi, Marinela Contreras, Jimmy Semakula, Marta Sánchez-Sánchez, Clara Muñoz-Hernández, Swidiq Mugerwa, Paul Kasaija, Halid Kirunda, Gabriela de la Fuente, Rubén Fernández-Melgar, Marta Rafael, Isabel G. Fernández de Mera, Moses Matovu, Ivan Kyakuwa, Moses Dhikusooka, Godfrey Nsereko, Paul Boma, James Bugeza, Mwesigwa Moses, Agnes Namukasa, Philip Obonyo, Nicholas Ssekabunga, Okeny E. Adyero, Justus Rutaisire, Christian Gortazar, José de la Fuente   +25 more
doaj   +6 more sources

Akirin/Subolesin regulatory mechanisms at host/tick-pathogen interactions. [PDF]

Microlife, 2022
Ticks and tick-borne pathogens such as Anaplasma phagocytophilum affect human and animal health worldwide and thus the characterization of host/tick–pathogen interactions is important for the control of tick-borne diseases.
de la Fuente J, Artigas-Jerónimo S, Villar M.   +2 more
europepmc   +7 more sources

Transovarial silencing of the subolesin gene in three-host ixodid tick species after injection of replete females with subolesin dsRNA

Parasitology Research, 2007
RNA interference (RNAi) has become the most powerful experimental tool for the study of gene function in ticks. Subolesin, initially called 4D8, was found to be protective against tick infestations when used as a vaccine and was shown to be highly ...
Fuente, José de la, Manzano Román, Raúl, Kocan, Katherine M.   +2 more
core   +4 more sources