Results 21 to 30 of about 276 (96)

Heat inactivated mycobacteria, alpha‐Gal and zebrafish: Insights gained from experiences with two promising trained immunity inductors and a validated animal model

Immunology, Volume 167, Issue 2, Page 139-153, October 2022., 2022
BCG vaccine, a live and attenuated strain of Mycobacterium bovis, and fungal β‐glucans, derived from Saccharomyces cerevisiae or Candida albicans, have been traditionally used in experimental studies aiming to induce non‐specific cross‐protection and to assess the mechanism involved in the trained immunity phenomenon.
Ramón A. Juste, Elisa Ferreras‐Colino, José de la Fuente, Mercedes Domínguez, María A. Risalde, Lucas Domínguez, Alejandro Cabezas‐Cruz, Christian Gortázar   +7 more
wiley   +1 more source

Reciprocal regulation of NF-kB (Relish) and Subolesin in the tick vector, Ixodes scapularis. [PDF]

PLoS ONE, 2013
BackgroundTick Subolesin and its ortholog in insects and vertebrates, Akirin, have been suggested to play a role in the immune response through regulation of nuclear factor-kappa B (NF-kB)-dependent and independent gene expression via interaction with ...
Victoria Naranjo, Nieves Ayllón, José M Pérez de la Lastra, Ruth C Galindo, Katherine M Kocan, Edmour F Blouin, Ruchira Mitra, Pilar Alberdi, Margarita Villar, José de la Fuente   +9 more
doaj   +1 more source

Tick Importin-α Is Implicated in the Interactome and Regulome of the Cofactor Subolesin

Pathogens, 2021
Ticks and tick-borne diseases (TBDs) represent a burden for human and animal health worldwide. Currently, vaccines constitute the safest and most effective approach to control ticks and TBDs.
Sara Artigas-Jerónimo, Margarita Villar, Alejandro Cabezas-Cruz, Grégory Caignard, Damien Vitour, Jennifer Richardson, Sandrine Lacour, Houssam Attoui, Lesley Bell-Sakyi, Eleonore Allain, Ard M. Nijhof, Nina Militzer, Sophia Pinecki Socias, José de la Fuente   +13 more
doaj   +1 more source

Immunoinformatic Analysis to Identify Proteins to Be Used as Potential Targets to Control Bovine Anaplasmosis

International Journal of Microbiology, Volume 2020, Issue 1, 2020., 2020
Omics sciences and new technologies to sequence full genomes provide valuable data that are revealed only after detailed bioinformatic analysis is performed. In this work, we analyzed the genomes of seven Mexican Anaplasma marginale strains and the data from a transcriptome analysis of the tick Rhipicephalus microplus.
Sergio D. Rodríguez-Camarillo, Rosa E. Quiroz-Castañeda, Hugo Aguilar-Díaz, José E. Vara-Pastrana, Diego Pescador-Pérez, Itzel Amaro-Estrada, Fernando Martínez-Ocampo, Todd R. Callaway   +7 more
wiley   +1 more source

A Novel Combined Scientific and Artistic Approach for the Advanced Characterization of Interactomes: The Akirin/Subolesin Model

Vaccines, 2020
The main objective of this study was to propose a novel methodology to approach challenges in molecular biology. Akirin/Subolesin (AKR/SUB) are vaccine protective antigens and are a model for the study of the interactome due to its conserved function in ...
Sara Artigas-Jerónimo, Juan J. Pastor Comín, Margarita Villar, Marinela Contreras, Pilar Alberdi, Israel León Viera, Leandro Soto, Raúl Cordero, James J. Valdés, Alejandro Cabezas-Cruz, Agustín Estrada-Peña, José de la Fuente   +11 more
doaj   +1 more source

Subolesin expression in response to pathogen infection in ticks

BMC Immunology, 2010
Background Ticks (Acari: Ixodidae) are vectors of pathogens worldwide that cause diseases in humans and animals. Ticks and pathogens have co-evolved molecular mechanisms that contribute to their mutual development and survival.
La Barbera Giuseppa, Mani Rinosh, Nijhof Ard M, Villar Margarita, Blouin Edmour F, Almazán Consuelo, Galindo Ruth C, Kocan Katherine M, Scimeca Salvatore, Alongi Angela, Mitra Ruchira, Torina Alessandra, Zivkovic Zorica, Caracappa Santo, Jongejan Frans, de la Fuente José   +15 more
doaj   +1 more source

Vaccination against Rhipicephalusmicroplus: an alternative to chemical control? [PDF]

Ciência Rural, 2023
: Rhipicephalus (Boophilus) microplus is a hard tick endemic in livestock-growing regions and causes economic losses in the largest beef-producing countries, including Brazil, Mexico, Argentina, Australia and Uruguay.
Lucas Andre Dedavid e Silva, Abid Ali, Carlos Termignoni, Itabajara da Silva Vaz Júnior   +3 more
doaj   +1 more source

Evidence of the role of tick subolesin in gene expression

BMC Genomics, 2008
Background Subolesin is an evolutionary conserved protein that was discovered recently in Ixodes scapularis as a tick protective antigen and has a role in tick blood digestion, reproduction and development.
Blouin Edmour F, Galindo Ruth C, de la Lastra José, Canales Mario, Almazán Consuelo, Nijhof Ard M, Ayoubi Patricia, Naranjo Victoria, Maritz-Olivier Christine, de la Fuente José, Gortazar Christian, Jongejan Frans, Kocan Katherine M   +12 more
doaj   +1 more source

Impact of Subolesin and Cystatin Knockdown by RNA Interference in Adult Female Haemaphysalis longicornis (Acari: Ixodidae) on Blood Engorgement and Reproduction

Insects, 2018
Currently, multi-antigenic vaccine use is the method of choice for the strategic control of ticks. Therefore, determining the efficacy of combined antigens is a promising avenue of research in the development of anti-tick vaccines.
Md. Khalesur Rahman, Mohammad Saiful Islam, Myungjo You   +2 more
doaj   +1 more source

Vaccination with Recombinant Subolesin Antigens Provides Cross-Tick Species Protection in Bos indicus and Crossbred Cattle in Uganda

Vaccines, 2020
Cattle tick infestations and transmitted pathogens affect animal health, production and welfare with an impact on cattle industry in tropical and subtropical countries.
Paul D. Kasaija, Marinela Contreras, Fredrick Kabi, Swidiq Mugerwa, José de la Fuente   +4 more
doaj   +1 more source