Results 31 to 40 of about 476 (134)

Control of multiple arthropod vector infestations with subolesin/akirin vaccines

Vaccine, 2017
Diseases transmitted by arthropod vectors such as mosquitoes, ticks and sand flies greatly impact human and animal health and thus their control is important for the eradication of vector-borne diseases (VBD).
Lucientes Curdi, Javier, Fuente, José de la, Moreno-Cid, Juan A., Villar, Margarita, Gortázar, Christian, Estrada-Peña, Agustín, Pérez de la Lastra, José Manuel   +6 more
core   +5 more sources

A combination of antibodies against Bm86 and Subolesin inhibits engorgement of Rhipicephalus australis (formerly Rhipicephalus microplus) larvae in vitro [PDF]

Parasites & Vectors, 2019
Background Rhipicephalus microplus is a hard tick species that has a high impact on cattle health and production in tropical and subtropical regions. Recently, ribosomal DNA and morphological analysis resulted in the reinstatement of R.
Jos J. A. Trentelman, Hendry Teunissen, Jos A. G. M. Kleuskens, Jos van de Crommert, José de la Fuente, Joppe W. R. Hovius, Theo P. M. Schetters   +6 more
doaj   +2 more sources

Modelling protein-protein interactions for the design of vaccine chimeric antigens with protective epitopes. [PDF]

PLoS ONE
Ticks and tick-borne diseases are a growing burden worldwide and vaccines are effective control interventions. Vaccine formulations with tick antigens such as BM86/BM95 (BM) and Subolesin (SUB) have shown reduction in tick fitness and infestation in ...
Marinela Contreras, Marta Rafael, Isidro Sobrino, Consuelo Almazán, Juan J Pastor Comín, James J Valdés, Carlos Roberto Prudencio, Daniel Ferreira de Lima Neto, Veniamin A Borin, Pratul K Agarwal, Paul D Kasaija, Rubén Fernández-Melgar, Justus Rutaisire, José de la Fuente   +13 more
doaj   +2 more sources

One-year follow-up evaluation of approved Subolesin anti-tick vaccine in Uganda

Vaccine
After approval of the Subolesin-based anti-tick vaccine in Uganda, we completed a one-year follow-up evaluation study. The results showed significantly 2.1-5.0-fold higher anti-SUB IgG antibody titers in vaccinated cattle in Mbarara and Maruzi with ...
Fuente, Gabriela de la, Fuente, José de la, Semakula, Jimmy, Gortázar, Christian, Kyakuwa, Ivan, Contreras, Marinela, Kasaija, Paul D., Rutaisire, Justus, Kabi, Fredrick, Mugerwa, Swidiq   +9 more
core   +4 more sources

Reduction of tick infections with Anaplasma marginale and A. phagocytophilum by targeting the tick protective antigen subolesin

Parasitology Research, 2006
Subolesin was recently shown by both gene silencing and immunization with the recombinant protein to protect against tick infestations, and to cause reduced tick survival and degeneration of gut and salivary gland tissues.
Fuente, José de la, Blouin, Edmour F., Almazán, Consuelo, Naranjo, María Victoria, Kocan, Katherine M.   +4 more
core   +4 more sources

Targeting the tick protective antigen subolesin reduces vector infestations and pathogen infection by Anaplasma marginale and Babesia bigemina

Vaccine, 2017
The ultimate goal of vector vaccines is the control of vector infestations while reducing pathogen infection and transmission to protect against the many diseases caused by vector-borne pathogens.
Merino, Octavio, Fuente, José de la, Moreno-Cid, Juan A., Galindo, Ruth C., Villar, Margarita, Almazán, Consuelo, Canales, Mario   +6 more
core   +4 more sources

Subolesin knockdown in tick cells provides insights into vaccine protective mechanisms

Vaccine
Ticks as obligate blood-feeding arthropod vectors of pathogenic viruses, bacteria, protozoa and helminths associated with prevalent tick-borne diseases (TBDs) worldwide.
Fuente, José de la, Alberdi, Pilar, Villar, Margarita, Artigas-Jerónimo, Sara, Estrada-Peña, Agustín, de la Fuente, José   +5 more
core   +7 more sources

Heat inactivated mycobacteria, alpha‐Gal and zebrafish: Insights gained from experiences with two promising trained immunity inductors and a validated animal model

Immunology, Volume 167, Issue 2, Page 139-153, October 2022., 2022
BCG vaccine, a live and attenuated strain of Mycobacterium bovis, and fungal β‐glucans, derived from Saccharomyces cerevisiae or Candida albicans, have been traditionally used in experimental studies aiming to induce non‐specific cross‐protection and to assess the mechanism involved in the trained immunity phenomenon.
Ramón A. Juste, Elisa Ferreras‐Colino, José de la Fuente, Mercedes Domínguez, María A. Risalde, Lucas Domínguez, Alejandro Cabezas‐Cruz, Christian Gortázar   +7 more
wiley   +1 more source

Subolesin/Akirin Vaccines for the Control of Arthropod Vectors and Vectorborne Pathogens [PDF]

Transboundary and Emerging Diseases, 2013
Diseases transmitted by arthropod vectors such as mosquitoes, ticks and sand flies greatly impact human and animal health, and therefore, their control is important for the eradication of vectorborne diseases (VBD). Vaccination is an environmentally friendly alternative for vector control that allows control of several VBD by targeting their common ...
Fuente, José de la, Moreno-Cid, Juan A., Galindo, Ruth C., Almazán, Consuelo, Kocan, Katherine M., Merino, Octavio, Pérez de la Lastra, José Manuel, Estrada-Peña, Agustín, Blouin, Edmour F.   +8 more
openaire   +3 more sources

Subolesin: a 20-year path from discovery to an effective tick vaccine

Expert Review of Vaccines
Subolesin: a 20-year path from discovery to an effective tick ...
José de la Fuente, Consuelo Almazán, Katherine M. Kocan   +2 more
doaj   +4 more sources