Results 121 to 130 of about 671,072 (327)

Stigma‐related barriers to medical cannabis as harm reduction for substance use disorder: Obstacles and opportunities for improvement [PDF]

open access: hybrid, 2023
Florriann Fehr   +7 more
openalex   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

open access: yesFEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan   +6 more
wiley   +1 more source

A Survey on Substance Abuse Related Deaths Referred to Tehran's Legal Medicine Organization During 2007 and 2008 [PDF]

open access: yesActa Medica Iranica, 2011
Doubtlessly one of the major problems in Iran is drug abuse or substance abuse. The transmission of HIV/AIDS has made the problem so complicated that has created an urgent need for a campaign against this awful phenomenon.
Hamid Reza Daneshparvar   +2 more
doaj   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

open access: yesFEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp   +13 more
wiley   +1 more source

Prevalence Studies of Substance-Related Disorders: A Systematic Review of the Literature [PDF]

open access: bronze, 2004
Julian M. Somers   +3 more
openalex   +1 more source

Psychiatric disorders among young male adult prisoners: a cross sectional study in a Malaysian prison [PDF]

open access: yes, 2010
Introduction: In recent years there has been an increase in the number of young people in prison. This study is the firstto look at the proportion of psychiatric disorders among young adultprisoners.
Baharuddin, Azlin   +4 more
core  

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

open access: yesFEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

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