Results 121 to 130 of about 1,322,584 (361)

Modeling neurocognitive and neurobiological recovery in addiction [PDF]

, 2019
This book focuses on "what to know" and "how to apply" information, prioritizing novel principles and delineating cutting-edge assessment, phenotyping and treatment ...
Abé, Agartz, Aharonovich, Almeida, Anderson, Bae, Bates, Bernardin, Blaine, Block, Bolla, Brody, Buhler, Cardenas, Cardenas, Cavazos-Rehg, Chang, Chang, Charlet, Crews, Crews, de Wit, Demirakca, Di Sclafani, Dlugos, Dom, Dominguez-Salas, Duka, Durazzo, Durazzo, Durazzo, Durazzo, Durazzo, Durazzo, Durazzo, Durazzo, Durazzo, Durazzo, Durazzo, Durazzo, Durazzo, Durazzo, Durazzo, Durazzo, Durazzo, Durazzo, Durazzo, Eldreth, Ernst, Ernst, Ernst, Ersche, Ersche, Fein, Fein, Fein, Fernandez-Serrano, Fernandez-Serrano, Franklin, Gansler, Gazdzinski, Gazdzinski, Gazdzinski, Gazdzinski, Giorgi, Glass, Goldstein, Goldstein, Hanlon, Hasin, Heinz, Hermann, Hirsiger, Hoefer, Holman, Humphreys, Hwang, Iudicello, Kalman, Ke, Kim, Klein, Koob, Le Berre, Licata, Loeber, Mackey, Matochik, Matochik, Medina, Meyerhoff, Meyerhoff, Meyerhoff, Meyerhoff, Meyerhoff, Meyerhoff, Meyerhoff, Mon, Mon, Mon, Moorman, Morales, Moreno-Alcázar, Moss, Murray, Murray, Nader, Nicolas, Nordahl, Noyan, O'Neill, Oishi, Oscar-Berman, Oscar-Berman, Parks, Parvaz, Passetti, Pennington, Pennington, Pfefferbaum, Prescot, Prescot, Rabin, Rando, Rezapour, Rogers, Rourke, Rupp, Sailasuta, Salo, Schmidt, Schulte, Segobin, Seo, Seo, Simon, Sneider, Sorg, Stavro, Stevens, Streeter, Sullivan, Sullivan, Sullivan, Sullivan, Thompson, Tunving, van Eijk, Verdejo-Garcia, Verdejo-Garcia, Verdejo-Garcia, Volkow, Volkow, Volkow, Volkow, Volkow, Volkow, Volkow, Volkow, Vonmoos, Walitzer, Wang, Wang, Wang, Weber, Weinberger, Weinberger, Weinberger, Williams, Witkiewitz, Xiao, Yang, Yeh, Yoon, Younger, Yucel, Zahr, Zahr, Zatorre, Zou   +179 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Housing situation and healthcare for patients in a psychiatric centre in Berlin, Germany: a cross-sectional patient survey [PDF]

, 2019
OBJECTIVE: To determine the housing situation among people seeking psychiatric treatment in relation to morbidity and service utilisation. DESIGN: Cross-sectional patient survey.
Bermpohl, Felix, Brückner, Anne, Bäuml, Josef, Gutwinski, Stefan, Heidrich, Sascha, Krausz, Michael R., Majic, Tomislav, Rössler, Wulf, Saathoff, Ute, Schouler-Ocak, Meryam, Schreiter, Stefanie, Zulauf, Jamie   +11 more
core   +1 more source

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source

Decreasing brain activity caused by acute administration of ketamine and alcohol – A randomized, controlled, observer-blinded experimental study

Frontiers in Pharmacology
IntroductionSubstance abuse is a major public health problem. In recent years, ketamine, which is a parenteral anesthetic, has been consumed increasingly as an illicit drug together with alcohol, although little is known of how this association alters ...
Luan Oliveira Ferreira, Luan Oliveira Ferreira, Esther Padilha da Silveira, Clarissa A. Paz, Maria K. Otake Hamoy, Gabriela B. Barbosa, Murilo F. Santos, Raína M. Conceição, Anthony Lucas G. Amaral, Karina Dias Resende, Dielly Catrina Favacho Lopes, Moisés Hamoy   +11 more
doaj   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Efficacy of the Therapeutic Game "Trisquel" in the Treatment of Patients With Substance-Related Disorders Randomized Clinical Study. [PDF]

Front Psychiatry, 2022
Piñón-Blanco A, Vergara-Moragues E, Gutiérrez-Martínez O, Fernández-Palleiro P, Rodrigues S, Rodrigues-Amorím D, Lage-López MT, González-López A, Velasquez T, Amorim M, Lloves-Moratinos M, Viéitez-Fernández I, Sabio-Fernandez G, Graña-Torralba R, Vilar-Díaz V, Carrera-Machado I, Cancelo-Martinez J, Ferreira A, Cardoso S, Rivera-Baltanás T, Otero-Lamas F, Olivares JM, Spuch C.   +22 more
europepmc   +1 more source

Stigma‐related barriers to medical cannabis as harm reduction for substance use disorder: Obstacles and opportunities for improvement [PDF]

, 2023
Florriann Fehr, Lindsay A. Lo, Christopher J. Nelson, Kate Nanson, Lauren Diehl, K. Nielson, Hudson Reddon, Zach Walsh   +7 more
openalex   +1 more source