Results 81 to 90 of about 601,648 (321)

Bullying involvement and substance use among Brazilian adolescent students

Revista Panamericana de Salud Pública, 2018
Objective. Although bullying involvement has been associated with adolescent substance use, most of this evidence comes from high-income countries. Little is known about substance use among perpetrator-victims in low- and middle-income countries.
Natalia Woolley, James Macinko
doaj   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Psychiatric disorders among young male adult prisoners: a cross sectional study in a Malaysian prison [PDF]

, 2010
Introduction: In recent years there has been an increase in the number of young people in prison. This study is the firstto look at the proportion of psychiatric disorders among young adultprisoners.
Baharuddin, Azlin, I., Normala, Mohd Yusof, Salina Akhtar, Nik Jaafar, Nik Ruzyanei, Zakaria, Hazli   +4 more
core  

Gaming addiction, definition, and measurement: a large-scale empirical study [PDF]

, 2013
Aims: Although the general public appears to have embraced the term 'video game addiction', the scientific debate as to whether 'gaming addiction' can actually be considered an addiction similar to substance addictions of DSM-IV is still unsettled. To
Griffiths, MD, Konijn, EA, Roelofsma, PHMP, Spekman, MLC   +3 more
core   +1 more source

Time, the final frontier

Molecular Oncology, EarlyView.
This article advocates integrating temporal dynamics into cancer research. Rather than relying on static snapshots, researchers should increasingly consider adopting dynamic methods—such as live imaging, temporal omics, and liquid biopsies—to track how tumors evolve over time.
Gautier Follain, Michal Dibus, Omkar Joshi, Guillaume Jacquemet   +3 more
wiley   +1 more source

Genetic and neurophysiological correlates of the age of onset of alcohol use disorders in adolescents and young adults. [PDF]

, 2013
Discrete time survival analysis was used to assess the age-specific association of event-related oscillations (EROs) and CHRM2 gene variants on the onset of regular alcohol use and alcohol dependence.
Almasy, Laura, Bauer, Lance, Bierut, Laura, Bucholz, Kathleen, Chorlian, David B, Dick, Danielle, Edenberg, Howard J, Foroud, Tatiana, Goate, Alison, Hesselbrock, Victor, Kang, Sun J, Kramer, John, Kuperman, Sam, Manz, Niklas, Nurnberger, John, Porjesz, Bernice, Rangaswamy, Madhavi, Rice, John, Schuckit, Marc, Tischfield, Jay, Wang, Jen-Chyong   +20 more
core   +2 more sources

Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?

Molecular Oncology, EarlyView.
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley   +1 more source

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

Hispanic Subgroups, Acculturation, and Substance Abuse Treatment Outcomes [PDF]

, 2015
This study explored Hispanic subgroup differences in substance use treatment outcomes, and the relationship of acculturation characteristics to these outcomes.
Akhtar, Maleeha, Carmody, Tom, Chartier, Karen G., Stebbins, Mary B., Walters, Scott T., Warden, Diane   +5 more
core   +2 more sources

Caffeine consumption of medical students in Korea: amount and symptoms based on a 2023 survey [PDF]

Korean Journal of Medical Education
Purpose To investigate the form and level of daily caffeine intake recommended above 400 mg in medical students expected to consume caffeinated beverages to enhance their performance.
Seong Woo Choi, Ye Won Kim, Chang Yong Lee, Hyung Su Jang, Hee Seung Chae, Ju Ha Choi, Young Hwii Ko   +6 more
doaj   +1 more source