Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Smoking, alcohol, and substance use and rates of quitting during pregnancy: is it hard to quit?
Ahmet Bulent Yazici,1 Hilal Uslu Yuvaci,2 Esra Yazici,3 Ebru Halimoglu Caliskan,4 Arif Serhan Cevrioglu,2 Atila Erol3 1Department of Psychiatry, Training and Research Hospital, 2Faculty of Medicine, Department of Obstetrics and Gynaecology, 3Faculty of ...
Yazici AB +5 more
doaj
Critical analysis of the theory of movement in movement in Allameh Tabatabai's view point [PDF]
Sadr al-Matahin proposed the movement in the category of substance by proposing the theory of substance movement. But he, like other philosophers, did not accept the movement in other categories, especially in categories whose individuals are gradually ...
Abdollah Nasri, Zeynab Yousofzadeh
doaj +1 more source
Whatever happened to meaning? Commentary on Millikan: A common structure for concepts of individuals, stuffs, and real kinds [PDF]
Even in infancy, concept formation has to do with creating meaning, not with tracking substances. Preverbal infants can identify a substance such as a dog, but their first concept of this substance is not dog but animal.
Mandler, JM
core
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
THE CAPADOCIAN TRADITION REGARDING THE UNDERSTANDING OF THE TERM NATURE AS EMPLOYED BY JOHN THE GRAMMARIAN IN HIS POLEMIC WITH SEVERUS OF ANTIOCH [PDF]
This article analyses the use of the term Nature as employed in the polemics of the supporters of the council of Chalcedon against their opponents, as exemplified in the controversy between John of Caesarea and Severus of Antioch.
Sergey Kozhukhov
doaj
Substance abuse treatment: what do we know? an economist's perspective [PDF]
The substance abuse treatment literature has basically dealt with four important questions: 1) Is treatment effective? 2) Are all programs equally effective? 3) why do programs differ in their effectiveness?
Machado, Matilde P.
core +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Non-Standard Stainless: Laruelle, Inconsistency and Sense-impressions
"Stains" can serve as a metaphor for the role allotted to meaninglessness not only by partisans of the deterritorializing force of "brute matter", but also by diagnosers of symbolic incompleteness.
David Bremner
doaj

