Results 171 to 180 of about 51,824 (261)

TIMP2 promotes AKI‐CKD transition by inducing tubular maladaptive repair and cell senescence via targeting Wnt/β‐catenin signalling

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
1. TIMP2 is upregulated in injured renal tubules and promotes maladaptive repair and cell senescence. 2. Genetic deletion of TIMP2 in tubular epithelial cells attenuates renal fibrosis and improves mitochondrial function. 3. TIMP2 activates Wnt/β‐catenin signalling by binding to LRP6 via an MMP‐independent mechanism.
Dongxue Xu, Haichuan Yu, Jingjing Pang, Xiaoyu Zhang, Jun Jiang, Yiming Li, Zhiyong Peng   +6 more
wiley   +1 more source

Substance Use and Cardiac Implantable Electronic Devices: A Single Institution Analysis of Re-Hospitalization, Follow-Up Rate, and Complications to Predict Patient Outcomes. [PDF]

Cureus
Stoecker A, Kang P, White MD.
europepmc   +1 more source

Pharmacoepidemiology of Oxycodone in the USA: An Observational Study of ARCOS, Medicaid, and Medicare Drug Databases

Pharmacology Research &Perspectives, Volume 14, Issue 1, February 2026.
ABSTRACT The US continues to battle an opioid crisis, substantially influenced by prescription opioids, with nearly 80 000 opioid‐related deaths in 2023. This study aims to characterize oxycodone's distribution in the United States (US) from 2000 to 2023 using three data sources.
Jay P. Solgama, Apoorva Pradhan, Kenneth L. McCall, Brian J. Piper   +3 more
wiley   +1 more source

Limited effects of zolmitriptan maintenance on the pharmacodynamic profile of intravenous cocaine in humans. [PDF]

Behav Pharmacol
Stoops WW, Lile JA, Alcorn JL, Hatton KW, Hays LR, Anderson DM, Neisewander JL.   +6 more
europepmc   +1 more source

Managing Drug–Drug Interactions Involving the Non‐Prescription Opioid Loperamide Through Physiologically Based Pharmacokinetic Modeling

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.
ABSTRACT Loperamide is a widely used nonprescription peripherally acting opioid indicated for diarrhea. Loperamide undergoes extensive first‐pass metabolism, primarily by cytochrome (CYP) 3A and CYP2C8, with minor contributions from CYP2B6 and CYP2D6, and intestinal efflux by P‐glycoprotein (P‐gp).
Zhu Zhou, Garrett R. Ainslie, Mengyao Li, Jean Dinh, Maciej J. Zamek‐Gliszczynski, Ping Zhao, Mary F. Paine   +6 more
wiley   +1 more source

Pharmacometric‐Based Evaluation of Salmeterol and Its Metabolite α‐Hydroxysalmeterol in Plasma and Urine: Practical Implications for Doping Control

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.
ABSTRACT Salmeterol is a commonly used β2‐agonist included on the List of Prohibited Substances and Methods published by the World Anti‐Doping Agency (WADA). We developed a population pharmacokinetic (popPK) model to describe the PK of salmeterol including its major metabolite, α‐hydroxysalmeterol, in plasma and urine after inhalation.
Paul Thoueille, Anne Danion, Morten Hostrup, Michael Petrou, Koen Deventer, Thierry Buclin, François R. Girardin, Irene Mazzoni, Olivier Rabin, Monia Guidi   +9 more
wiley   +1 more source

Clinical Outcomes and Challenges in the Management of Spondylodiscitis in Patients With Intravenous Drug Abuse: A Multicenter Retrospective Study. [PDF]

Global Spine J
Albrecht C, Delank M, Wostrack M, Jelgersma C, Tkatschenko D, Onken J, Neuhoff J, Vajkoczy P, Meyer B, Joerger AK.   +9 more
europepmc   +1 more source

Effects of Intravenous Ketamine on Posttraumatic Stress Disorder (PTSD): A Systematic Review

Acta Psychiatrica Scandinavica, Volume 153, Issue 2, Page 95-107, February 2026.
ABSTRACT Introduction Posttraumatic stress disorder (PTSD) is a mental disorder resulting from exposure to traumatic events. Evidence suggests that ketamine may be efficacious in treating PTSD, however, ketamine's mechanisms in treating PTSD remain unclear. Herein, this review aims to evaluate the clinical outcomes of ketamine treatment in persons with
Liyang Yin, Andy Lu, Gia Han Le, Christine E. Dri, Sabrina Wong, Kayla M. Teopiz, Heidi Xu, Roger Ho, Taeho Greg Rhee, Heidi Ka Ying Lo, Maria‐Christina Sioufi, Yang Jing Zheng, Hezekiah C. T. Au, Hernan F. Guillen‐Burgos, Bing Cao, Roger S. McIntyre   +15 more
wiley   +1 more source

Upper Limb Wound Profile in Patients Who Inject Heroin and Fentanyl Mixed With Xylazine. [PDF]

Hand (N Y)
Dos Santos AK, Sisroe Dos Santos TA, Doddala B, Zabel D.   +3 more
europepmc   +1 more source

Trans‐Tissue Effects of Hippocampus‐ and Blood‐Derived DNA Methylation Risk Scores on Bipolar Disorder Diagnosis

Bipolar Disorders, Volume 28, Issue 1, February 2026.
ABSTRACT Objectives Bipolar disorder (BD) is a common psychiatric disorder with complex genetic and epigenetic underpinnings. This study aimed to investigate whether methylation risk scores (MRSs) derived from epigenome‐wide association studies (EWASs) for BD risk in living peripheral blood and postmortem hippocampal tissues are associated with BD ...
Kazutaka Ohi, Daisuke Fujikane, Kentaro Takai, Ayumi Kuramitsu, Yukimasa Muto, Shunsuke Sugiyama, Toshiki Shioiri   +6 more
wiley   +1 more source