Results 91 to 100 of about 262,152 (305)

Role of cognitive behavior therapy on people with substance abuse in the craving phase

, 2023
Anak Agung Gede Agung Satrya Megada, Luh Nyoman Alit Aryani   +1 more
openalex   +2 more sources

Iron Overload Mediates the Differential Cell Fate of Astrocytes from Neurons and Its Regulatory Mechanisms in Ischemic Stroke

Advanced Science, EarlyView.
Upon ischemia/reperfusion‐induced iron overload condition, neurons and astrocytes exhibit similar oxidative stress changes but opposite alterations in endogenous antioxidant defense mechanisms, leading to divergent ferroptotic outcomes. The iron deposition and neuronal loss are increased within the perilesional cortex of stroke patients ...
Yi Guo, Yue Wang, Yong Ni, Bin Bo, Jinzhi He, Yongming Zhu, Aiping Qin, Xianyong Zhou, Huaping Du, Yuan Liu, Tianyao Wang, Yudu Li, Yibo Zhao, Zengai Chen, Zhipei Liang, Yao Li, Yuan Xu, Huiling Zhang   +17 more
wiley   +1 more source

USP9X as a Candidate Mediator of Prenatal Aspirin‐Induced Ovarian Reserve Reduction in Offspring Mice

Advanced Science, EarlyView.
This study suggests that prenatal aspirin exposure is associated with reduced ovarian reserve in offspring, associated with HDAC1‐linked epigenetic downregulation of Usp9x as a candidate mechanism. These preclinical findings provide new insights into fetal‐origin ovarian disorders and contribute to the evidence base concerning aspirin's gestational ...
Yating Li, Caiyun Ge, Wai Yen Yim, Hui Feng, Tiancheng Wu, Lu Chen, Qiaohua Xiong, Shumin Pan, Mei Wang, Huijun Chen, Yuanzhen Zhang, Hui Wang   +11 more
wiley   +1 more source

NAD⁺ Reduction in Glutamatergic Neurons Induces Lipid Catabolism and Neuroinflammation in the Brain via SARM1

Advanced Science, EarlyView.
NAD⁺ homeostasis maintains neuronal integrity through opposing actions of NMNAT2 and SARM1. Loss of NMNAT2 in glutamatergic neurons reprograms cortical metabolism from glucose to lipid catabolism, depletes lipid stores, and triggers inflammation and neurodegeneration.
Zhen‐Xian Niou, Sen Yang, Andrea Enriquez, Nino A. Espinas, Anoosha Sri, Caliel D. Hines, Jason M. Tennessen, Chia‐Shan Wu, Jui‐Yen Huang, Hui‐Chen Lu   +9 more
wiley   +1 more source

Relationship Between Social, Economic and Cultural Factors and Women’s Tendency Toward Crystal Methamphetamine or Opium Use

Iranian Rehabilitation Journal, 2018
Objectives: High prevalence of stimulants use –especially crystalline methamphetamine (crystal meth)-, which required extensive medical and rehabilitation interventions is a major problem in Iran; health care system.
Omid Massah, Ali Farhoudian, Roya Noori, Salaheddin Ghaderi, Elaheh Ahounbar, Seyed Hadi Mousavi   +5 more
doaj  

Is smokeless tobacco a healthier option in patients with AUD? A follow-up study during treatment

Harm Reduction Journal
Introduction Smoking is negatively related to mental health, but there is a paucity of research on the relationship between the use of smokeless tobacco, such as snus, and mental health outcomes, especially in people with alcohol use disorders (AUD). The
Lars Lien, Ingeborg Bolstad, Jørgen G. Bramness   +2 more
doaj   +1 more source

Linking Childhood and Adult Criminality: Using a Life Course Framework to Examine Childhood Abuse and Neglect, Substance Use and Adult Partner Violence [PDF]

, 2013
Anita Minh, Flora I. Matheson, Nihaya Daoud, Sarah Hamilton‐Wright, Cheryl Pedersen, Heidi Borenstein, Patricia O’Campo   +6 more
openalex   +1 more source

SEVERE MEDICATIONAL PANCREATITIS IN A YOUNG PATIENT DUE TO PSYCHOACTIVE SUBSTANCE ABUSE

, 2022
Guilherme Alves de Oliveira, Augusto Araboni Mendes Barcelos Manna, Pamela Renata Leite, Debora Duarte Melo, Kilder Carmo dos Santos, João Gilberto Kazuo Aguena, Eduardo Fernandes Arruda, Loysleny Elias França, Nathália Joana Garcia Gonçalves, Larissa Maria Lucas, Raíssa Andrade Águas, Juni Marcos Borges Alves Nogueira   +11 more
openalex   +2 more sources

Intrinsic MicroRNA‐10a Restricts Regulatory T Cell Suppressive Function and Intestinal Repair by Coordinating Transcriptional, Metabolic, and Epithelial Repair Pathways

Advanced Science, EarlyView.
This study identifies microRNA‐10a (miR‐10a) as a key brake on regulatory T cell (Treg) suppressive function and intestinal repair. By targeting Blimp‐1, Uqcrq, and amphiregulin, miR‐10a restrains transcriptional, metabolic, and epithelial programs essential for Treg activity.
Wenjing Yang, Tianming Yu, Hui Yang, Suxia Yao, Ruihua Ma, Elizabeth M Steinert, Karen M Ridge, Weiguo Cui, Navdeep S Chandel, Yingzi Cong   +9 more
wiley   +1 more source

Seipin‐Mediated Lipid Droplet Formation in Cardiomyocytes Ameliorates Cardiac Ischemia/Reperfusion Injury

Advanced Science, EarlyView.
Lipid droplets (LDs) protect the heart against lipotoxicity in cardiac ischemia/reperfusion (I/R) injury; however, they are insufficient to prevent cardiomyocyte death. Seipin plays a central role in the insufficient formation of LDs, subsequent lipotoxicity, and myocardial injury during cardiac I/R injury.
Changyun Liu, Junxia Zhang, Yusi Chen, Geng Shen, Yufei Han, Zihao Zhou, Jinxuan Chen, Xuya Kang, Huilin Qu, Jiaxin Duanmu, Haibao Shang, Yingjia Li, Wei Huang, Yan Zhang   +13 more
wiley   +1 more source