Results 91 to 100 of about 48,018 (311)

Detection and quantification of aripiprazole and its metabolite, dehydroaripiprazole, by gas chromatography-mass spectrometry in blood samples of psychiatric patients

, 2008
[[abstract]]Aripiprazole is a novel antipsychotic drug for the treatment of schizophrenia and schizoaffective disorders. In this study, a new method using gas chromatography-mass spectrometry (GC-MS) was developed and validated for the detection of ...
Huang, HC; Liu, CH; Lan, TH; Hu, TM; Chiu, HJ; Wu, YC; Tseng, YL
core   +1 more source

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Insights Into Child Abuse and Neglect in the Washington DC, Maryland, and Virginia (DMV) Area: Evidence and Opportunities

Global Pediatric Health
Child abuse and neglect (CAN) significantly impact health, the economy, and society. This narrative review examines CAN in the Washington DC, Maryland, and Virginia (DMV) region, comparing it with national and international levels.
Intima Alrimawi PhD, RN, Elizabeth Bettini PhD, APRN, PCNS-BC, Clishia Taylor DMIN, MBA, RN, CDI, ICTTP, Ahmad Rajeh Saifan PhD, RN, Nabeel Al-Yateem PhD, RN   +4 more
doaj   +1 more source

Biomimetic Ru‐Mn Nanozyme with Cascade Catalytic Activity Attenuates Secondary Brain Injury in Intracerebral Hemorrhage

Advanced Science, EarlyView.
Ru–Mn composite nanozymes are engineered to mimic dual‐enzyme cascade catalysis, enabling efficient ROS clearance and neuroinflammation suppression. In collagenase‐ and autologous blood‐induced ICH mouse models, intranasal and intravenous administration reduced hematoma volume, preserved BBB integrity, and improved neurological recovery.
Zhongxin Duan, Peng Li, Yue Wang, Xin Qi, Wanyu Wang, Yongzhong Cheng, Huabin Zhang, Xin Hu, Xiang Gao   +8 more
wiley   +1 more source

Au Ordered Array Substrate for Rapid Detection and Precise Identification of Etomidate in E-Liquid Through Surface-Enhanced Raman Spectroscopy

Nanomaterials
Etomidate (ET), a medical anesthetic, is increasingly being incorporated into e-liquids for consumption and abuse as a new psychoactive substance (NPS), leading to significant social issues.
Yan Mo, Xiaoping Zhang, Ke Zou, Wen Xing, Xiayang Hou, Yu Zeng, Yugang Cai, Ruixiang Xu, Hongwen Zhang, Weiping Cai   +9 more
doaj   +1 more source

The Severity of Dependence Scale detects medication misuse and dependence among hospitalized older patients

BMC Geriatrics, 2019
Background In older patients, timely recognition and treatment of medication misuse and dependence are crucial to secure medication safety and to avoid increasing health expenditure. Nonetheless, the detection of this condition remains challenging due to
Socheat Cheng, Tahreem Ghazal Siddiqui, Michael Gossop, Espen Saxhaug Kristoffersen, Christofer Lundqvist   +4 more
doaj   +1 more source

Charming or harming: Case studies of emotional abuse in heterosexual intimate partner relationships

, 2013
Emotional abuse in the absence of physical abuse is often unrecognised. Although the literature identifies the insidious nature of this type of abuse and the physiological, psychological and emotional harm it often causes, knowledge of how women come to ...
Corbett, Catherine
core  

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source

Differentiation of Therapeutic and Illicit Drug Use via Metabolite Profiling

Metabolites
Objectives: The therapeutic use of controlled substances, particularly opioids, stimulants, and benzodiazepines, has significantly increased in recent decades.
Stanila Stoeva-Grigorova, Nadezhda Hvarchanova, Silvia Gancheva, Miroslav Eftimov, Kaloyan D. Georgiev, Maya Radeva-Ilieva   +5 more
doaj   +1 more source

Validade do cage para rastrear pacientes com dependência ao álcool internados em Hospital Geral. [PDF]

, 2003
Trabalho de Conclusão de Curso - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Departamento de Clínica Médica, Curso de Medicina, Florianópolis ...
Castells, Maria Alicia
core