Results 81 to 90 of about 48,018 (311)

GPR124 Alleviates Blood–Brain Barrier Disruption by Enhancing Microvascular Endothelial Function after Traumatic Brain Injury

Advanced Science, EarlyView.
Our study reveals the protective role of GPR124 in maintaining BBB integrity and promoting neurological recovery following TBI. It makes a significant contribution by uncovering a novel molecular interaction between GPR124 and FGFBP1 and linking this to activation of the Wnt/β‐catenin signaling pathway in vascular repair mechanisms.
Chen Wang, Lin Cai, Qiuyuan Gong, Yang Yang, Yuqing Liang, Xinyu Niu, Lai Wei, Ze Liu, Shengju Wu, Yinghui Men, Yaohui Tang, Jun Ding, Hengli Tian, Hao Chen   +13 more
wiley   +1 more source

Uso de álcool e tabaco entre estudantes de Psicologia da Universidade Federal do Espírito Santo Alcohol and tobacco use among Psychology students at the Federal University of Espírito Santo

Jornal Brasileiro de Psiquiatria, 2013
OBJETIVO: Traçar o perfil do uso de álcool e tabaco entre universitários do curso de graduação em Psicologia do Centro de Ciências Humanas e Naturais da Universidade Federal do Espírito Santo.
Marcos Vinícius Ferreira dos Santos, Denis Soprani Pereira, Marluce Miguel de Siqueira   +2 more
doaj  

Oronasal fistula associated with narcotic substance abuse: a case report

Annali di Stomatologia
An oronasal fistula, defined as an abnormal communication between the oral and nasal cavities, most frequently results from surgical trauma, infection, or neoplasia.
Aldo Vangjeli, Erda Qorri, Nasira Kopliku   +2 more
doaj   +1 more source

Marburg Virus Glycoprotein Is a Remarkable Virulent Factor Linked to Hemorrhagic Pathology: Evidence from Multimodal Experimental Systems

Advanced Science, EarlyView.
By integrating data from in vitro, ex vivo, and in vivo models, our research identifies the MARV glycoprotein as a remarkable hemorrhagic factor, filling a major gap in this important field. It also provides practical experimental tools for the basic research on viral pathogenesis and applied research aimed at antiviral intervention for hemorrhagic ...
Ting Yao, Hang Liu, Yanfeng Yao, Wei Deng, Jiawen Sun, Zhenyu Kang, Ashaq Ali, Chao Shan, Zhiming Yuan, Fei Deng, Hualin Wang, Yun‐Jia Ning   +11 more
wiley   +1 more source

PSYCHOTROPIC DRUG USE AMONG TEENAGE PUBLIC SCHOOL STUDENTS

Cogitare Enfermagem, 2015
The aim of this study was to identify the association between socio-demographic characteristics and use of alcohol and other drugs by teenage public school students. This was an exploratory study, conducted in the first half of 2014.
Bruno Miranda Pereira, Karolyne Araujo Resende, Cecília Godoi Campos, Sebastião Júnior Henrique Duarte, Ricardo Bezerra Cavalcante, Richardson Miranda Machado   +5 more
doaj   +1 more source

Stress reactivity in heroin dependence [PDF]

, 2015
Background: Heroin dependence is a chronic relapsing disorder characterized by a compulsion to seek and use heroin despite the negative consequences. In addition to the diagnostic criteria, heroin dependence is associated with an altered function of the ...
Gerber, Hana
core   +1 more source

Detecting Selection Effects in Community Implementations of Family-Based Substance Abuse Prevention Programs

American Journal of Public Health, 2010
To calculate valid estimates of the costs and benefits of substance abuse prevention programs, selection effects must be identified and corrected. A supplemental comparison sample is typically used for this purpose, but in community-based program implementations, such a sample is often not available.
HILL, Laura G, GOATES, Scott G, ROSENMAN, Robert   +2 more
openaire   +4 more sources

LC3B Mediated SETDB1‐Accounted Alcoholic Steatohepatitis via Lipidation‐Dependent LAP and Lipidation‐Independent Nuclear Stabilization

Advanced Science, EarlyView.
SETDB1 is progressively downregulated in ALD, correlating with disease severity. SETDB1 deficiency impairs LAP by disrupting Rubicon membrane localization, leading to defective lipid droplet clearance. Concurrently, loss of SETDB1 reduces nuclear LC3B, causing R‐loop accumulation and cGAS‐STING‐driven inflammation. Lipidated LC3B mediates LAP‐dependent
Yi Zhang, Tan Wei, Jiahang Wu, Chuixu Lin, Dongbo Zhu, Yanhui Li, Shuting Shi, Shishun Huang, Leiming Jiang, Hongzhi Wang, Meiqi Song, Pengfei Gao, Xu Wu, Mingjian Fan, Chaofeng Wei, Qian Wang, Lihui Qu, Zhigang Wang   +17 more
wiley   +1 more source

Social adaptability and substance abuse: Predictors of depression among hemodialysis patients?

BMC Nephrology, 2013
Background Several aspects linked to social are involved in the onset of depressive feelings. We aimed to find out if social adaptability and substance abuse predict depression among end-stage renal disease (ESRD) patients undergoing hemodialysis (HD ...
Santos Paulo Roberto, Arcanjo Francisco Plácido Nogueira   +1 more
doaj   +1 more source

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source