Results 101 to 110 of about 3,724,758 (302)

Insights Into Child Abuse and Neglect in the Washington DC, Maryland, and Virginia (DMV) Area: Evidence and Opportunities

Global Pediatric Health
Child abuse and neglect (CAN) significantly impact health, the economy, and society. This narrative review examines CAN in the Washington DC, Maryland, and Virginia (DMV) region, comparing it with national and international levels.
Intima Alrimawi PhD, RN, Elizabeth Bettini PhD, APRN, PCNS-BC, Clishia Taylor DMIN, MBA, RN, CDI, ICTTP, Ahmad Rajeh Saifan PhD, RN, Nabeel Al-Yateem PhD, RN   +4 more
doaj   +1 more source

SUBSTANCE ABUSE TREATMENT: WHAT DO WE KNOW? AN ECONOMIST’S PERSPECTIVE [PDF]

The substance abuse treatment literature has basically dealt with four important questions: 1) Is treatment effective? 2) Are all programs equally effective? 3) why do programs differ in their effectiveness?
Matilde P. Machado
core  

Treating adolescent substance abuse: state of the science

, 2006
In October, 2001, just a month after the World Trade Center tragedy, a 2-day conference was scheduled to be held in Coral Gables, Florida entitled Treating Adolescent Substance Abuse: State of the Science funded by the National Institute on Drug Abuse ...
Rowe, Cynthia L., Liddle, Howard A.
core   +1 more source

Thymosin Alpha‐1 Provides Direct Neuroprotection by Engaging the Orexin Receptor HCRTR1 to Suppress Neuronal Necroptosis

Advanced Science, EarlyView.
In this study, we unveil a thymus‐brain endocrine axis wherein Tα1 engages HCRTR1 to inhibit RIPK3‐mediated necroptosis. This study nominates the Tal‐HCRTR1‐RIPK3 axis as a potent and clinically translatable therapeutic target for stroke and neurodegeneration.
Xinmei Kang, Shisi Wang, Liubin Zhang, Mengyan Hu, Xiaotao Su, Yuxin Liu, Qin Qin, Haotong Yi, Liling Yuan, Wei Cai, Lei Wei, Zhengqi Lu   +11 more
wiley   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Au Ordered Array Substrate for Rapid Detection and Precise Identification of Etomidate in E-Liquid Through Surface-Enhanced Raman Spectroscopy

Nanomaterials
Etomidate (ET), a medical anesthetic, is increasingly being incorporated into e-liquids for consumption and abuse as a new psychoactive substance (NPS), leading to significant social issues.
Yan Mo, Xiaoping Zhang, Ke Zou, Wen Xing, Xiayang Hou, Yu Zeng, Yugang Cai, Ruixiang Xu, Hongwen Zhang, Weiping Cai   +9 more
doaj   +1 more source

Gestational Hypoxia Disrupts Medial Ganglionic Eminence Progenitor Dynamics and Interneuron Development in Schizophrenia

Advanced Science, EarlyView.
FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni, Qiancheng Zhang, Youhui Jiang, Huiying Yao, Chuqing Zhou, Xiaoyi Tian, Shiyingnan Gao, Jun Zhao, Xinyi Ren, Naxin Xu, Mengshan Fu, Liansheng Zhao, Xueyu Qi, Xueli Yu, Wanjun Guo, Sangmi Chung, Fan Guo, Tao Li   +17 more
wiley   +1 more source

Innovative Nanomaterial‐Based Approaches for the Recognition of Amphetamine in Attention Deficit Hyperactivity Disorder Management

Analytical Science Advances
The rising incidence of amphetamine misuse, particularly in the context of attention deficit hyperactivity disorder treatment, underscores the urgent need for sensitive and effective detection methods.
Ilghar Zeinaly, Ghazal Koohkansaadi, Majid Hassanzadeh‐Khanmiri, Ahmad Mobed, Saeid Charsouei, Arash Mohagheghi   +5 more
doaj   +1 more source

Differentiation of Therapeutic and Illicit Drug Use via Metabolite Profiling

Metabolites
Objectives: The therapeutic use of controlled substances, particularly opioids, stimulants, and benzodiazepines, has significantly increased in recent decades.
Stanila Stoeva-Grigorova, Nadezhda Hvarchanova, Silvia Gancheva, Miroslav Eftimov, Kaloyan D. Georgiev, Maya Radeva-Ilieva   +5 more
doaj   +1 more source

Workflow to facilitate the detection of new psychoactive substances and drugs of abuse in influent urban wastewater

Journal of Hazardous Materials
The complexity around the dynamic markets for new psychoactive substances (NPS) forces researchers to develop and apply innovative analytical strategies to detect and identify them in influent urban wastewater. In this work a comprehensive suspect screening workflow following liquid chromatography - high resolution mass spectrometry analysis was ...
Bade, R., van Herwerden, D., Rousis, N., Adhikari, S., Allen, D., /Baduel, Christine, Bijlsma, L., Boogaerts, T., Burgard, D., Chappell, A., Driver, E. M., Sodre, F. F., Fatta-Kassinos, D., Gracia-Lor, E., Gracia-Marín, E., Halden, R. U., Heath, E., Jaunay, E., Krotulski, A., Lai, F. Y., Löve, A. S. C., O'Brien, J. W., Oh, J. E., Pasin, D., Castro, M. P., Psichoudaki, M., Salgueiro-Gonzalez, N., Gomes, C. S., Subedi, B., Thomas, K. V., Thomaidis, N., Wang, D. G., Yargeau, V., Samanipour, S., Mueller, J.   +34 more
openaire   +9 more sources