Results 101 to 110 of about 48,018 (311)

Commentary on ‘The research translation problem : Alcohol screening and brief intervention in primary care – Real world evidence supports theory’

, 2011
Health Research Board12M embargo - release after 24/06/2012 - AV 21/10/2011 au, ke - kpw1/11 ...
Walter Cullen, Field, Catherine-Anne, Bury, Gerard, Barry, Joe, Suzi Lyons, Klimas, Jan, Jan Klimas, Joe Barry, Barry, Joseph, Field, Catherine Anne, Keenan, Eamon, Smyth, Bobby P., Smyth, Bobby P, Cullen, Walter, Lyons, Suzi, Catherine Anne Field, Bobby Smyth, Gerard Bury, Eamon Keenan   +18 more
core   +1 more source

FASLG Derived from Fibroblasts in Hydroxyapatite‐Rich Microenvironment Induces Urothelial Anoikis to Trigger Randall's Plaque Exposure

Advanced Science, EarlyView.
Randall's plaques (RP) serve as the nidus for calcium oxalate (CaOx) kidney stones. The current study reveals that hydroxyapatite (HAP) crystals activate the THY1–GSK3α/β–β‐catenin axis in renal interstitial fibroblasts (hRIFs), inducing FASLG secretion.
Minghui Liu, Maolan Wu, Meng Gao, Yongchao Li, Miao Yuan, Zhangcheng Liao, Zhi Liu, Yizhou Wang, Yu Cui, Jinbo Chen, Cheng He, Zhiyong Chen, Feng Zeng, Hequn Chen, Zewu Zhu   +14 more
wiley   +1 more source

Study Of Methamphetamine Abuse Among Drug Abuse Positive Cases Attending Sohag Clinical Toxicology Laboratory By New Validated HPLC-DAD Method [PDF]

Ain Shams Journal of Forensic Medicine and Clinical Toxicology
Introduction: Substance abuse becomes a global challenge with alarming increase in use of crystal meth (shabu) in Egypt. For that, there is an urgent need to develop a reliable analytical method in routine operations.
Rania Radwan, Nour Abouzied, Ahmed Mora, Ali Hassan, Mai Abd ElKader   +4 more
doaj   +1 more source

A Chirality‐Converted Bacteriolytic Dodecapeptide Regulates Vibrio‐Induced Polymicrobial Infection and Ameliorates Invasion‐Associated Gut Microbiota Disequilibrium

Advanced Science, EarlyView.
Multidrug‐resistant Vibrio infections are rising rapidly and threaten coastal populations worldwide. This study introduces D‐zp37, a chirality‐engineered antimicrobial peptide with exceptional potency against resistant Vibrio species. D‐zp37 kills planktonic cells, blocks mixed‐species biofilms, disrupts essential bacterial stress responses, and shows ...
Ping Zeng, Qipeng Cheng, Xiaoxu Zhang, Honglan Wang, Jinghan Zhang, Xinyi Ding, Pengfei Zhang, Lanhua Yi, Kwok‐Yin Wong, Kin‐Fai Chan, Sheng Chen, Sharon Shui Yee Leung   +11 more
wiley   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Counselor-provided SBIRT for hospitalized adults with substance misuse or disordered use: evaluating hospital utilization outcomes and economic cost [PDF]

, 2019
The misuse and disordered use of alcohol and illicit drugs in the United States creates serious consequences for people and their families and communities, such as severe physical health issues (Substance Abuse and Mental Health Administration [SAMHSA ...
McCall, Marcia H., NC DOCKS at The University of North Carolina at Greensboro   +1 more
core  

Workflow to facilitate the detection of new psychoactive substances and drugs of abuse in influent urban wastewater

Journal of Hazardous Materials
The complexity around the dynamic markets for new psychoactive substances (NPS) forces researchers to develop and apply innovative analytical strategies to detect and identify them in influent urban wastewater. In this work a comprehensive suspect screening workflow following liquid chromatography - high resolution mass spectrometry analysis was ...
Bade, R., van Herwerden, D., Rousis, N., Adhikari, S., Allen, D., /Baduel, Christine, Bijlsma, L., Boogaerts, T., Burgard, D., Chappell, A., Driver, E. M., Sodre, F. F., Fatta-Kassinos, D., Gracia-Lor, E., Gracia-Marín, E., Halden, R. U., Heath, E., Jaunay, E., Krotulski, A., Lai, F. Y., Löve, A. S. C., O'Brien, J. W., Oh, J. E., Pasin, D., Castro, M. P., Psichoudaki, M., Salgueiro-Gonzalez, N., Gomes, C. S., Subedi, B., Thomas, K. V., Thomaidis, N., Wang, D. G., Yargeau, V., Samanipour, S., Mueller, J.   +34 more
openaire   +9 more sources

ANKS1B in the Nucleus Accumbens Controls Escalated Cocaine Self‐Administration via Regulating CBP‐FoxO3 Complex

Advanced Science, EarlyView.
ANKS1B in the nucleus accumbens plays a critical role in the transition from controlled to escalated cocaine intake. Mechanistically, ANKS1B interacts with CBP to epigenetically suppress FoxO3 through H3K27 acetylation. The ANKS1B‐CBP‐FoxO3 signaling cascade presents a novel theraputic target for the treatment of cocaine addiction.
Liping Yang, Xiaoxuan Wu, Xuan Chen, Chao Peng, Zihang Li, Shumin Gao, Shiqiu Meng, Jing Dong, Dong Wu, Liying Lv, Ying Han, Yanxue Xue, Lin Lu, Jie Shi, Jianfeng Liu, Yan Sun   +15 more
wiley   +1 more source

Accidental Detection of Cocaine in Urine in Pediatric Patients: Case Series and Literature Review

Children
Infantile occult exposure to cocaine in domestic environments represents a complex clinical and medico-legal problem, which can be associated with abuse and neglect and with potential short- and long-term health risks for children.
Martina Focardi, Ilenia Bianchi, Marta Romanelli, Valentina Gori, Laura Nanni, Fabio Vaiano, Stefania Losi   +6 more
doaj   +1 more source

Amuc_1473 Links Gut Microbes to Skeletal Homeostasis and Counteracts Multifactorial Osteoporosis

Advanced Science, EarlyView.
Amuc_1473, a previously uncharacterized protein enriched in Akkermansia muciniphila‐derived extracellular vesicles, is identified as a gut–bone messenger that promotes osteogenesis and inhibits osteoclastogenesis by engaging transcriptional and translational regulators in bone cells.
Shan‐Shan Rao, Hai‐Jin Zeng, Zun Wang, Chun‐Gu Hong, Yi‐Juan Tan, Yan‐Xin Duan, Jing‐Yao Luo, Ming‐Jie Luo, Yi‐Wei Liu, Xin Wang, Yi Luo, Teng‐Fei Wan, Yong Zhou, Zheng‐Guang Wang, Guo‐Wen Hu, Hao Yin, Xin‐Yue Hu, Zhen‐Xing Wang, Ze‐Hui He, Si‐Yi Cheng, Wei Du, Zhe Guan, Hai‐Li Lang, Hong‐Ji Liu, Jia Cao, Peng Chen, Jiang‐Hua Liu, Hui Xie, Chun‐Yuan Chen   +28 more
wiley   +1 more source