Molecular Oncology, EarlyView.Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu +11 more
wiley +1 more source
Substance P in heart failure: the good and the bad.
International Journal of Cardiology, 2014 Heather M Dehlin, S. Levick
semanticscholar +1 more source
Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
wiley +1 more source
A reversible growth inhibition of isolated tomato roots [PDF]
, 1942 Introduction. - It is known that certain bacteria are inhibited in their growth by the presence of sulfanilamide or related compounds in the nutrient medium, and it has been suggested by Fildes(1) and by Woods(2) that this inhibition is due to specific ...
Bonner, James
core
Interaction of physalaemin, substance P, and eledoisin with specific membrane receptors on pancreatic acinar cells. [PDF]
, 1979 Robert T. Jensen, Jerry D. Gardner
openalex +1 more source
Ubiquitination of transcription factors in cancer: unveiling therapeutic potential
Molecular Oncology, EarlyView.In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley +1 more source
Intradermal substance P as a challenge agent in healthy individuals. [PDF]
Clin Transl Sci, 2023 Ten Voorde W +16 more
europepmc +1 more source
Two observations made by P. Francesco Lana, the author of the prodromus premised to Arte Maestra, concerning some of the effects of the Burning Concave of Lions; and also an odd salt extracted out of a metallic substance: Taken out of the same Venetian Journal [PDF]
P. Francesco Lana
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Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Molecular Oncology, EarlyView.Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley +1 more source
Central injection of substance P elicits grooming behavior and motor inhibition in mice [PDF]
, 1979 Richard J. Katz
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