Results 301 to 310 of about 2,039,151 (340)
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European Journal of Pain, 2000
Substance P is considered to be an important neuropeptide in nociceptive processes. Although substance P was described more than 60 years ago, there is still controversy about its exact role in nociception. This article reviews the current knowledge about the function of substance P in pain.
Snijdelaar, D.G. +3 more
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Substance P is considered to be an important neuropeptide in nociceptive processes. Although substance P was described more than 60 years ago, there is still controversy about its exact role in nociception. This article reviews the current knowledge about the function of substance P in pain.
Snijdelaar, D.G. +3 more
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The International Journal of Biochemistry & Cell Biology, 2001
This article provides a brief overview of the history of substance P from its discovery in the 1930s to the present day. The development of substance P receptor agonists and antagonists, and more recently the employment of transgenic mice, provide a framework to explore the functional role of substance P.
HARRISON, SELENA, GEPPETTI, PIERANGELO
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This article provides a brief overview of the history of substance P from its discovery in the 1930s to the present day. The development of substance P receptor agonists and antagonists, and more recently the employment of transgenic mice, provide a framework to explore the functional role of substance P.
HARRISON, SELENA, GEPPETTI, PIERANGELO
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General and Comparative Endocrinology, 1980
Abstract Immunoreactive substance P (ISP) was measured by radioimmunoassay in acid-acetone tissue extracts in representative species of invertebrates (phyla Coelenterata and Mollusca) and of non-mammalian vertebrates (Elasmobranchii, Teleostei, Amphibia, Reptilia, Aves).
T. Creagh +4 more
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Abstract Immunoreactive substance P (ISP) was measured by radioimmunoassay in acid-acetone tissue extracts in representative species of invertebrates (phyla Coelenterata and Mollusca) and of non-mammalian vertebrates (Elasmobranchii, Teleostei, Amphibia, Reptilia, Aves).
T. Creagh +4 more
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Radioimmunoassay for Substance P
Nature New Biology, 1973IN 1931, Von Euler and Gaddum demonstrated the presence of a substance in extracts of brain and of intestine that causes contraction of isolated intestinal muscle in vitro and vasodilatation and hypotension in vivo1. These effects occur in the presence of atropine and hence are independent of acetylcholine.
Hugh David Niall +4 more
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Substance P and antinociception
Peptides, 1983Substance P (SP)-induced antinociception is still a topic of controversy. Some investigators have failed to see an antinociceptive effect of SP, particularly following intraperitoneal administration. In the present experiments SP induced significant hot plate antinociception in male mice, following intraperitoneal administration.
Michael E. Hall, John M. Stewart
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Comparison of crude bovine subcortical substance P with synthetic substance P [PDF]
Naunyn-Schmiedeberg's Archives of Pharmacology, 1973 Synthetic substance P (SP) was compared with the gut-contracting peptide Fa from bovine subcortex by means of thin-layer chromatography, paper electrophoresis, enzymatic digestion, and biological assays. With all four techniques differences in behaviour between Fa and synthetic SP were found, which lead to the conclusion that both active principles are
G. Zetler, H. Iven
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Nature, 1976
SUBSTANCE P (SP)1 has long been known to have marked effects on the central nervous system (CNS). Lembeck2 suggested that SP might be a transmitter of primary sensory impulses, an hypothesis supported by subsequent investigators3,4. Early work on SP was carried out using natural material, which unless highly purified, is known to be contaminated with ...
Emery Zimmermann +5 more
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SUBSTANCE P (SP)1 has long been known to have marked effects on the central nervous system (CNS). Lembeck2 suggested that SP might be a transmitter of primary sensory impulses, an hypothesis supported by subsequent investigators3,4. Early work on SP was carried out using natural material, which unless highly purified, is known to be contaminated with ...
Emery Zimmermann +5 more
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Nature New Biology, 1971
SUBSTANCE P has been synthesized by the solid-phase procedure of Merrifield1,2 according to the sequence H-Arg-Pro-LysPro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 reported in the previous letter.
Geoffrey William Tregear +4 more
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SUBSTANCE P has been synthesized by the solid-phase procedure of Merrifield1,2 according to the sequence H-Arg-Pro-LysPro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 reported in the previous letter.
Geoffrey William Tregear +4 more
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Substance P and substance P receptors in bone and gingival tissues
Medical Electron Microscopy, 2001Substance P (SP) is an important member of the tachykinin family of neuropeptides, which work as neurotransmitters or neuromodulators. Recent advances in the analysis of SP receptors, particularly the neurokinin-1 receptors (NK1-Rs) that have high affinity for SP, have demonstrated that they are distributed not only in the cells of the neuronal or ...
Tetsuya Goto +3 more
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Differentiation of substance P and physalaemin
Naunyn-Schmiedebergs Archiv f�r Pharmakologie, 19691. The physical and chemical properties of substance P (extracted from bovine brain) and physalaemin were investigated by several methods. 2. During paper electrophoresis at pH 4.95 substance P migrates towards the cathode, physalaemin remains at the starting point. 3.
F. Lembeck, B. Sprössler, F. Geipert
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