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European Journal of Pain, 2000
Substance P is considered to be an important neuropeptide in nociceptive processes. Although substance P was described more than 60 years ago, there is still controversy about its exact role in nociception. This article reviews the current knowledge about the function of substance P in pain.
Snijdelaar, D.G. +3 more
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Substance P is considered to be an important neuropeptide in nociceptive processes. Although substance P was described more than 60 years ago, there is still controversy about its exact role in nociception. This article reviews the current knowledge about the function of substance P in pain.
Snijdelaar, D.G. +3 more
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The International Journal of Biochemistry & Cell Biology, 2001
This article provides a brief overview of the history of substance P from its discovery in the 1930s to the present day. The development of substance P receptor agonists and antagonists, and more recently the employment of transgenic mice, provide a framework to explore the functional role of substance P.
HARRISON, SELENA, GEPPETTI, PIERANGELO
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This article provides a brief overview of the history of substance P from its discovery in the 1930s to the present day. The development of substance P receptor agonists and antagonists, and more recently the employment of transgenic mice, provide a framework to explore the functional role of substance P.
HARRISON, SELENA, GEPPETTI, PIERANGELO
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General and Comparative Endocrinology, 1980
Abstract Immunoreactive substance P (ISP) was measured by radioimmunoassay in acid-acetone tissue extracts in representative species of invertebrates (phyla Coelenterata and Mollusca) and of non-mammalian vertebrates (Elasmobranchii, Teleostei, Amphibia, Reptilia, Aves).
T, Creagh +4 more
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Abstract Immunoreactive substance P (ISP) was measured by radioimmunoassay in acid-acetone tissue extracts in representative species of invertebrates (phyla Coelenterata and Mollusca) and of non-mammalian vertebrates (Elasmobranchii, Teleostei, Amphibia, Reptilia, Aves).
T, Creagh +4 more
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Radioimmunoassay for Substance P
Nature New Biology, 1973IN 1931, Von Euler and Gaddum demonstrated the presence of a substance in extracts of brain and of intestine that causes contraction of isolated intestinal muscle in vitro and vasodilatation and hypotension in vivo1. These effects occur in the presence of atropine and hence are independent of acetylcholine.
D, Powell +4 more
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Substance P and antinociception
Peptides, 1983Substance P (SP)-induced antinociception is still a topic of controversy. Some investigators have failed to see an antinociceptive effect of SP, particularly following intraperitoneal administration. In the present experiments SP induced significant hot plate antinociception in male mice, following intraperitoneal administration.
M E, Hall, J M, Stewart
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Acetylcholinesterase hydrolyzes substance P
Neuroscience, 1980Highly purified preparations of acetylcholinesterase were obtained by affinity chromatography of both fetal calf serum and a commercial preparation derived from the electroplax of the electric eel. One major molecular form was isolated, which corresponded to the secretory form of acetylcholinesterase.
I W, Chubb, A J, Hodgson, G H, White
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