Results 311 to 320 of about 2,039,151 (340)
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Clinics in Dermatology, 1991
Abstract For centuries people have known that the seeds and membranes of certain species of plants of the nightshade family, notably capsicum, possess a principle that produces intense erythema, pain, and inflammation when applied to skin or mucous membrane.
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Abstract For centuries people have known that the seeds and membranes of certain species of plants of the nightshade family, notably capsicum, possess a principle that produces intense erythema, pain, and inflammation when applied to skin or mucous membrane.
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Inhibition of antidromic and substance P‐induced vasodilatation by a substance P antagonist
Acta Physiologica Scandinavica, 1981Indirect evidence has abundantly been presented to support the view that substance P (SP) is involved in the vasodilatation following activation of fine calibre pain fibres (Lembeck & Holzer 1979). In this respect, the dental pulp is interesting since it is richly supplied with SP‐immunoreactive nerves originating from the trigeminal system (Olgart
Joachim Hörig +5 more
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Airway responses to substance P and substance P fragments in the guinea pig
Pulmonary Pharmacology, 1988Airway responses to rapid intravenous infusions of substance P (SP), selected carboxy terminal fragments (SP3-11, SP5-11, SP7-11, and SP9-11), and an amino terminal fragment (SP1-9) were measured in anesthetized, mechanically ventilated guinea pigs. The dose of each peptide required to decrease pulmonary conductance (GL) to 50% of baseline value was ...
Jeffrey M. Drazen +2 more
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[15] Substance P and neurotensin
1986Publisher Summary This chapter describes two neuropeptides, substance P (SP) and neurotensin (NT). These two neuropeptides contain sequences analogous to tuftsin. Moreover, these peptides and their partial sequences containing the tuftsin-related domains displace labeled tuftsin from phagocytes and enhance their phagocytic capability.
Zvi Bar-Shavit, Rachel Goldman
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Effects of Substance P and Substance P Antagonists on Rat Salivary Secretion
Journal of Dental Research, 1986The intra-arterial infusion of substance P produced dose-related responses of both parotid and submandibular salivary secretion in anesthetized rats. The substance P-induced secretion in both glands was inhibited by the substance P analogues [D-Arg1, D-Trp7,9, Leu11]-substance P and [D-Arg1, D-Pro2, D-Trp7,9, Leu11]-substance P, but not by [D-Pro2, D ...
Emil Bobyock +2 more
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Properties of Substance P aggregates application to the synthesis and purification of Substance P
Biochemical and Biophysical Research Communications, 1983By 1H-NMR spectroscopy it has been shown that Substance P is largely aggregated at basic and acid pH and in saline solutions. These SP polymers dissociate rapidly by addition of pyridine and acetonitrile and slowly by addition of methanol. The difficulties previously encountered in the purification of SP and SP analogs may be attributed to this ...
Andrée Marquet +3 more
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Substance P and substance P receptor histochemistry in human neurodegenerative diseases
Regulatory Peptides, 1993Substance P immunoreactivity is localized in discrete subsets of neurons in the human cerebral cortex and basal ganglia. In the normal human cerebral cortex, a subset of aspiny local circuit neurons in deep cortical layers and the cortical subplate contain preprotachykinin mRNA and substance P immunoreactive.
James E. Krause +5 more
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Autoradiographic localization of substance P receptors using 125I substance P
Peptides, 1982This paper describes a method for localization of substance P receptors in the rat central nervous system using 125I labeled substance P in an autoradiographic procedure. Particularly high densities of substance P receptors were observed in the olfactory bulb, dentate gyrus, amygdala, superior colliculus, and locus coeruleus. Surprisingly low densities
Terry W. Moody +5 more
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1987
We have assessed the relative vasodilatory potencies of substance P, deca-substance P and nona-substance P in the canine forelimb. In pentobarbital anesthetized dogs (35 mg/kg, i.v., n=7) the right forelimb was perfused at constant flow via the brachial artery.
Buehn Mj, Dabney Jm, Dobbins De
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We have assessed the relative vasodilatory potencies of substance P, deca-substance P and nona-substance P in the canine forelimb. In pentobarbital anesthetized dogs (35 mg/kg, i.v., n=7) the right forelimb was perfused at constant flow via the brachial artery.
Buehn Mj, Dabney Jm, Dobbins De
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