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Substance P equals pain substance?
Nature, 1998Circumstantial evidence has led to the theory that substance P (SP) — an undecapeptide discovered over 60 years ago — is involved in the transmission of pain information from the central nervous system. More direct evidence is now provided by two studies of mice in which the function of SP has been genetically disrupted.
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Journal of Musculoskeletal Pain, 1998
(1998). Substance P and Fibromyalgia. Journal of Musculoskeletal Pain: Vol. 6, No. 3, pp. 29-35.
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(1998). Substance P and Fibromyalgia. Journal of Musculoskeletal Pain: Vol. 6, No. 3, pp. 29-35.
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1966
The physiological role of substance P (SP) is still largely a matter of conjecture. Its extremely high potency in pharmacological tests (stimulation of gut, depression of blood pressure, and vasodilation), its almost exclusive occurrence in the gut and certain areas of the brain (Pernow 1953; Lembeck and Zetler, 1962; McLennan, 1963), and its ...
Lyman C. Craig, Harry Meinardi
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The physiological role of substance P (SP) is still largely a matter of conjecture. Its extremely high potency in pharmacological tests (stimulation of gut, depression of blood pressure, and vasodilation), its almost exclusive occurrence in the gut and certain areas of the brain (Pernow 1953; Lembeck and Zetler, 1962; McLennan, 1963), and its ...
Lyman C. Craig, Harry Meinardi
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1966
In 1962 in New York I presented a paper on a method of isolating substance P from bovine brain (Zuber, 1963). Subsequently, I managed to improve and expand this method a little further at CIBA. Unfortunately, however, it was possible to continue this work for only one year — until May 1963.
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In 1962 in New York I presented a paper on a method of isolating substance P from bovine brain (Zuber, 1963). Subsequently, I managed to improve and expand this method a little further at CIBA. Unfortunately, however, it was possible to continue this work for only one year — until May 1963.
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Substance P and substance P antagonists
Current Opinion in Anaesthesiology, 1994openaire +2 more sources