Results 351 to 360 of about 22,248,138 (428)

Substance P and analgesia

Nature, 1976
SUBSTANCE P (SP)1 has long been known to have marked effects on the central nervous system (CNS). Lembeck2 suggested that SP might be a transmitter of primary sensory impulses, an hypothesis supported by subsequent investigators3,4. Early work on SP was carried out using natural material, which unless highly purified, is known to be contaminated with ...
Emery Zimmermann, Carl J. Getto, William A. Krivoy, Kenneth Neldner, E. Basil Reeve, John M. Stewart   +5 more
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Synthesis of Substance P

Nature New Biology, 1971
SUBSTANCE P has been synthesized by the solid-phase procedure of Merrifield1,2 according to the sequence H-Arg-Pro-LysPro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 reported in the previous letter.
Geoffrey William Tregear, Michael M. Chang, Susan E. Leeman, Hugh David Niall, John T. Potts   +4 more
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Substance P and substance P receptors in bone and gingival tissues

Medical Electron Microscopy, 2001
Substance P (SP) is an important member of the tachykinin family of neuropeptides, which work as neurotransmitters or neuromodulators. Recent advances in the analysis of SP receptors, particularly the neurokinin-1 receptors (NK1-Rs) that have high affinity for SP, have demonstrated that they are distributed not only in the cells of the neuronal or ...
Tetsuya Goto, Takayoshi Yamaza, Teruo Tanaka, Mizuho A. Kido   +3 more
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Distinct mechanism for antidepressant activity by blockade of central substance P receptors.

Science, 1998
The localization of substance P in brain regions that coordinate stress responses and receive convergent monoaminergic innervation suggested that substance P antagonists might have psychotherapeutic properties.
M. Kramer, N. Cutler, J. Feighner, R. Shrivastava, J. Carman, J. Sramek, S. Reines, Guanghan Liu, D. Snavely, E. Wyatt-Knowles, J. Hale, S. Mills, M. Maccoss, C. Swain, Timothy Harrison, R. Hill, F. Hefti, E. Scolnick, M. Cascieri, G. Chicchi, S. Sadowski, A. Williams, L. Hewson, David J. Smith, E. Carlson, R. Hargreaves, N. Rupniak   +26 more
semanticscholar   +1 more source

Differentiation of substance P and physalaemin

Naunyn-Schmiedebergs Archiv f�r Pharmakologie, 1969
1. The physical and chemical properties of substance P (extracted from bovine brain) and physalaemin were investigated by several methods. 2. During paper electrophoresis at pH 4.95 substance P migrates towards the cathode, physalaemin remains at the starting point. 3.
F. Lembeck, B. Sprössler, F. Geipert
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A potent nonpeptide antagonist of the substance P (NK1) receptor.

Science, 1991
CP-96,345 [(2S, 3S)-cis-2-(diphenylmethyl)-N-[(2-methoxyphenyl)- methyl]-1-azabicyclo[2.2.2]octan-3-amine] is a potent nonpeptide antagonist of the substance P (NK1) receptor.
R. Snider, J. W. Constantine, J. Lowe, K. P. Longo, W. Lebel, H. A. Woody, S. Drozda, MC Desai, FJ Vinick, RW Spencer   +9 more
semanticscholar   +1 more source

Capsaicin and substance P

Clinics in Dermatology, 1991
Abstract For centuries people have known that the seeds and membranes of certain species of plants of the nightshade family, notably capsicum, possess a principle that produces intense erythema, pain, and inflammation when applied to skin or mucous membrane.
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Inhibition of antidromic and substance P‐induced vasodilatation by a substance P antagonist

Acta Physiologica Scandinavica, 1981
Indirect evidence has abundantly been presented to support the view that substance P (SP) is involved in the vasodilatation following activation of fine calibre pain fibres (Lembeck & Holzer 1979). In this respect, the dental pulp is interesting since it is richly supplied with SP‐immunoreactive nerves originating from the trigeminal system (Olgart
Joachim Hörig, Sune Rosell, Karl Folkers, Leif Olgart, Panagiotis Panopoulos, Bertil Gazelius   +5 more
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Airway responses to substance P and substance P fragments in the guinea pig

Pulmonary Pharmacology, 1988
Airway responses to rapid intravenous infusions of substance P (SP), selected carboxy terminal fragments (SP3-11, SP5-11, SP7-11, and SP9-11), and an amino terminal fragment (SP1-9) were measured in anesthetized, mechanically ventilated guinea pigs. The dose of each peptide required to decrease pulmonary conductance (GL) to 50% of baseline value was ...
Jeffrey M. Drazen, Jeffrey M. Drazen, Stephanie A. Shore   +2 more
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[15] Substance P and neurotensin

1986
Publisher Summary This chapter describes two neuropeptides, substance P (SP) and neurotensin (NT). These two neuropeptides contain sequences analogous to tuftsin. Moreover, these peptides and their partial sequences containing the tuftsin-related domains displace labeled tuftsin from phagocytes and enhance their phagocytic capability.
Zvi Bar-Shavit, Rachel Goldman
openaire   +3 more sources