Results 361 to 370 of about 22,248,138 (428)
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Properties of Substance P aggregates application to the synthesis and purification of Substance P
Biochemical and Biophysical Research Communications, 1983By 1H-NMR spectroscopy it has been shown that Substance P is largely aggregated at basic and acid pH and in saline solutions. These SP polymers dissociate rapidly by addition of pyridine and acetonitrile and slowly by addition of methanol. The difficulties previously encountered in the purification of SP and SP analogs may be attributed to this ...
Andrée Marquet +3 more
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Effects of Substance P and Substance P Antagonists on Rat Salivary Secretion
Journal of Dental Research, 1986The intra-arterial infusion of substance P produced dose-related responses of both parotid and submandibular salivary secretion in anesthetized rats. The substance P-induced secretion in both glands was inhibited by the substance P analogues [D-Arg1, D-Trp7,9, Leu11]-substance P and [D-Arg1, D-Pro2, D-Trp7,9, Leu11]-substance P, but not by [D-Pro2, D ...
Emil Bobyock +2 more
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Substance P and substance P receptor histochemistry in human neurodegenerative diseases
Regulatory Peptides, 1993Substance P immunoreactivity is localized in discrete subsets of neurons in the human cerebral cortex and basal ganglia. In the normal human cerebral cortex, a subset of aspiny local circuit neurons in deep cortical layers and the cortical subplate contain preprotachykinin mRNA and substance P immunoreactive.
James E. Krause +5 more
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Autoradiographic localization of substance P receptors using 125I substance P
Peptides, 1982This paper describes a method for localization of substance P receptors in the rat central nervous system using 125I labeled substance P in an autoradiographic procedure. Particularly high densities of substance P receptors were observed in the olfactory bulb, dentate gyrus, amygdala, superior colliculus, and locus coeruleus. Surprisingly low densities
Terry W. Moody +5 more
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Hydrogen sulfide and substance P in inflammation.
Antioxidants and Redox Signaling, 2010Hydrogen sulfide (H(2)S) plays an important role in cardiovascular, central nervous, and gastrointestinal systems. Being the third gaseous mediator, H(2)S has been shown to act as a vasodilator.
M. Bhatia
semanticscholar +1 more source
Science, 1997
Substance P is released in the spinal cord in response to painful stimuli, but its role in nociceptive signaling remains unclear. When a conjugate of substance P and the ribosome-inactivating protein saporin was infused into the spinal cord, it was ...
P. Mantyh +9 more
semanticscholar +1 more source
Substance P is released in the spinal cord in response to painful stimuli, but its role in nociceptive signaling remains unclear. When a conjugate of substance P and the ribosome-inactivating protein saporin was infused into the spinal cord, it was ...
P. Mantyh +9 more
semanticscholar +1 more source
1987
We have assessed the relative vasodilatory potencies of substance P, deca-substance P and nona-substance P in the canine forelimb. In pentobarbital anesthetized dogs (35 mg/kg, i.v., n=7) the right forelimb was perfused at constant flow via the brachial artery.
Buehn Mj, Dabney Jm, Dobbins De
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We have assessed the relative vasodilatory potencies of substance P, deca-substance P and nona-substance P in the canine forelimb. In pentobarbital anesthetized dogs (35 mg/kg, i.v., n=7) the right forelimb was perfused at constant flow via the brachial artery.
Buehn Mj, Dabney Jm, Dobbins De
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Elevated cerebrospinal fluid levels of substance P in patients with the fibromyalgia syndrome.
Arthritis & Rheumatism, 1994OBJECTIVE To measure, and seek clinical correlates with, levels of substance P (SP) in the cerebrospinal fluid (CSF) of fibromyalgia syndrome (FMS) patients.
I. Russell +7 more
semanticscholar +1 more source
Science, 1992
Inhibition of cyclooxygenase by nonsteroidal anti-inflammatory drugs (NSAIDs) in the periphery is commonly accepted as the primary mechanism by which these agents produce a selective attenuation of pain (analgesia). NSAIDs are now shown to exert a direct
A. Malmberg, T. Yaksh
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Inhibition of cyclooxygenase by nonsteroidal anti-inflammatory drugs (NSAIDs) in the periphery is commonly accepted as the primary mechanism by which these agents produce a selective attenuation of pain (analgesia). NSAIDs are now shown to exert a direct
A. Malmberg, T. Yaksh
semanticscholar +1 more source
Comparative potencies of substance P, substance K and neuromedin K on brain substance P receptors
Neuropeptides, 1984The relative potency of substance P, substance K and neuromedin K on [3H]substance P binding has been compared in rat brain membrane preparations. Substance K and neuromedin K, two newly isolated substance P-related mammalian peptides, are very weak competitors for [3H]substance P binding sites.
Rémi Quirion, Carmencita Pilapil
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