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Substance P equals pain substance?
Nature, 1998Circumstantial evidence has led to the theory that substance P (SP) — an undecapeptide discovered over 60 years ago — is involved in the transmission of pain information from the central nervous system. More direct evidence is now provided by two studies of mice in which the function of SP has been genetically disrupted.
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Journal of Musculoskeletal Pain, 1998
(1998). Substance P and Fibromyalgia. Journal of Musculoskeletal Pain: Vol. 6, No. 3, pp. 29-35.
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(1998). Substance P and Fibromyalgia. Journal of Musculoskeletal Pain: Vol. 6, No. 3, pp. 29-35.
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Role of substance P in the cardiovascular system
Neuropeptides, 2016E. Mistrová+2 more
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1966
The physiological role of substance P (SP) is still largely a matter of conjecture. Its extremely high potency in pharmacological tests (stimulation of gut, depression of blood pressure, and vasodilation), its almost exclusive occurrence in the gut and certain areas of the brain (Pernow 1953; Lembeck and Zetler, 1962; McLennan, 1963), and its ...
Lyman C. Craig, Harry Meinardi
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The physiological role of substance P (SP) is still largely a matter of conjecture. Its extremely high potency in pharmacological tests (stimulation of gut, depression of blood pressure, and vasodilation), its almost exclusive occurrence in the gut and certain areas of the brain (Pernow 1953; Lembeck and Zetler, 1962; McLennan, 1963), and its ...
Lyman C. Craig, Harry Meinardi
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Involvement of substance P and the NK-1 receptor in human pathology
Amino Acids, 2014M. Muñoz, R. Coveñas
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Are the proposed substance P receptor sub-types, substance P receptors?
Life Sciences, 1984Recently, a number of laboratories have postulated the existence of receptor sub-types for substance P. This review is intended to represent a critical appraisal of these reports. In the majority of cases, the evidence for the existence of receptor sub-types has been obtained from observed potency differences of agonists.
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