Results 91 to 100 of about 53,729,253 (423)

Using illicit drugs alone in Vancouver, Canada: a gender-based analysis

Substance Abuse Treatment, Prevention, and Policy
Objectives Canada continues to experience an epidemic of toxic drug-related overdose deaths. Public health messaging emphasizes the dangers of using drugs alone as it restricts timely overdose response or renders it impossible, yet this practice remains ...
Kat Gallant, Kanna Hayashi, Eric C. Sayre, JinCheol Choi, Manal Mansoor, Thomas Kerr   +5 more
doaj   +1 more source

“Am I gonna get in trouble for acknowledging my will to be safe?”: Identifying the experiences of young sexual minority men and substance use in the context of an opioid overdose crisis

Harm Reduction Journal, 2020
Background North America and other parts of the globe are in the midst of a public health emergency related to opioid overdoses and a highly contaminated illicit drug supply.
Trevor Goodyear, Caroline Mniszak, Emily Jenkins, Danya Fast, Rod Knight   +4 more
doaj   +1 more source

Lower-risk substance use guidelines accessible by youth

Substance Abuse Treatment, Prevention, and Policy, 2023
Background Lower-risk substance use guidelines (LRSUGs) are an evidence-based harm reduction strategy used to provide information to people who use drugs so they can reduce harms associated with substance use.
Zakkaery R. Moebes, Kiffer G. Card, Brett Koenig, Cecilia Benoit   +3 more
doaj   +1 more source

Use of Performance-Enhancing Substances [PDF]

Pediatrics, 2016
This Clinical Report was reaffirmed August 2020. Performance-enhancing substances (PESs) are used commonly by children and adolescents in attempts to improve athletic performance. More recent data reveal that these same substances often are used for appearance-related reasons as well.
Michele LaBotz, Bernard A. Griesemer, Joel S. Brenner, Cynthia R. LaBella, Margaret A. Brooks, Alex Diamond, Amanda K. Weiss Kelly, Michele LaBotz, Kelsey Logan, Keith J. Loud, Kody A. Moffatt, Blaise Nemeth, Brooke Pengel, William Hennrikus   +13 more
openaire   +3 more sources

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

Innovations to the ECHO model to enhance reach and network-building among addiction clinicians in Western Canada

Addiction Science & Clinical Practice
Background Building capacity for evidence-based treatment and support for people with substance use disorders (SUD) is an urgent priority in the context of the toxic drug poisoning crisis.
Samantha Robinson, Isabella Brohman, Jenna van Draanen, Rivka Kushner, Nadia Fairbairn, Stephanie Glegg   +5 more
doaj   +1 more source

Tunguska similar impacts and origin of life [PDF]

arXiv, 2013
The author suggests new vision of mechanism of initiation of life on the planets after Tunguska similar impacts. This mechanism takes into consideration not only incoming cosmic organic substance but also information, which is connected to this substance.
arxiv  

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

The Adolescent Substance Use Risk Continuum: A Cultural, Strengths-Based Approach to Case Conceptualization [PDF]

, 2017
Many theories are used to conceptualize adolescent substance use, yet none adequately assist mental health professionals in assessing adolescents’ strengths and risk factors while incorporating cultural factors.
Cook, Jennifer, Miller, Alexis
core   +1 more source

Neural mechanisms of affective instability and cognitive control in substance use

, 2019
Objective: We explored the impact of affect on cognitive control as this relates to individual differences in affective instability and substance use.
Bodkyn, Carmen N., Holroyd, Clay
core   +1 more source