Results 131 to 140 of about 53,254,105 (402)

Polysubstance Use: A Broader Understanding of Substance Use During the Opioid Crisis.

open access: yesAmerican Journal of Public Health, 2019
Objectives. To understand important changes in co-occurring opioid and nonopioid drug use (i.e., polysubstance use) within the opioid epidemic in the United States.Methods.
T. Cicero   +2 more
semanticscholar   +1 more source

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

open access: yesFEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson   +7 more
wiley   +1 more source

Changing patterns of first e-cigarette flavor used and current flavors used by 20,836 adult frequent e-cigarette users in the USA

open access: yesHarm Reduction Journal, 2018
Background Understanding the role that flavors play in the population’s use of e-cigarettes and the impact that flavored e-cigarette products have on the population’s use of more harmful tobacco products, like conventional cigarettes, has been identified
Christopher Russell   +3 more
doaj   +1 more source

Too much free time: Coos County Youth who are least involved in out-of-school activities are most likely to use drugs and alcohol [PDF]

open access: yes, 2010
Carsey Institute researchers are seeing links between the self-reported substance use and involvement in out-of-school activities. As part of a ten-year tracking survey of high school students in Coos County, New Hampshire, this brief finds that those ...
Sharp, Erin H.
core   +1 more source

Women and substance use disorders

open access: yesMens Sana Monographs, 2009
Substance use disorders belong to the class of externalizing behaviours that are generally more common among men than women. Those women who do have substance disorders therefore deviate more from the norms of society compared with men, tend to live in an environment characterized by high risk of violence and other forms of abuse, and tend to be ...
Hecksher, Dorte, Hesse, Morten
openaire   +5 more sources

Mycobacterium tuberculosis sulfurtransferase SseA is activated by its neighboring gene product Rv3284

open access: yesFEBS Letters, EarlyView.
Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli   +10 more
wiley   +1 more source

Youth Marijuana and Prescription Drug Abuse in Anchorage [PDF]

open access: yes, 2016
Complete issue of Alaska Justice Forum 33(1), Spring 2016 at https://scholarworks.alaska.edu/handle/11122/6883.This article examines results of the Adult Perceptions of Anchorage Youth: 2015 Survey (APAYS) to examine perceptions and concerns of Anchorage
Lepage, Cory R., Rivera, Marny
core  

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