Results 131 to 140 of about 252,929 (281)

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Predicting substance use disorder using long-term attention deficit hyperactivity disorder medication records in Truven [PDF]

, 2019
Sajjad Fouladvand, Emily R. Hankosky, Heather Bush, Jin Chen, Linda P. Dwoskin, Patricia R. Freeman, Darren W. Henderson, Kathleen M. Kantak, Jeffery Talbert, Shiqiang Tao, Guo‐Qiang Zhang   +10 more
openalex   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Impaired olfactory function in substance use disorder. [PDF]

Psychopharmacology (Berl)
Raithel CU, Sherman GT, Epstein DH, Kahnt T.   +3 more
europepmc   +1 more source

Distinguishing Between Substance Use and Substance Use Disorder [PDF]

JAMA Internal Medicine, 2015
openaire   +2 more sources

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

Productivity Losses From Substance Use Disorder in the U.S. in 2023. [PDF]

Am J Prev Med
Ghimire R, Florence C, Guy G.
europepmc   +1 more source

Predictive Validity of a Cigarette Purchase Task in a Randomized Controlled Trial of Contingent Vouchers for Smoking in Individuals With Substance Use Disorders

, 2015
James MacKillop, Cara M. Murphy, Rosemarie A. Martin, Monika M. Stojek, Jennifer W. Tidey, Suzanne M. Colby, Damaris J. Rohsenow   +6 more
openalex   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Heart Rate Variability Biofeedback for Substance Use Disorder: A Randomized Clinical Trial. [PDF]

JAMA Psychiatry
Eddie D, Nguyen M, Zeng K, Mei S, Emery N.   +4 more
europepmc   +1 more source