Results 141 to 150 of about 1,878,278 (369)

Impulsivity mediates the association between narcissism and substance-related problems beyond the degree of substance use: a longitudinal observational study

BMC Psychiatry
Background Narcissism has been implied as a putative risk factor for substance use disorders (SUDs). However, previous research did not disentangle the degree of substance use from substance-related problems, the symptoms of SUDs.
Malin K. Hildebrandt, Josepha Noack, Raoul Wuellhorst, Tanja Endrass, Emanuel Jauk   +4 more
doaj   +1 more source

Sociodemographic Determinants, Early Maladaptive Schemas, and Childhood Traumas Increase the Risk of Substance and/or Alcohol Use in Women: A Case–Control Study

Addicta: The Turkish Journal on Addictions
In this case–control study, to determine the effect of early maladaptive schemas and childhood traumas under risk of alcohol and substance use in women was aimed.
Cinar Ozgu, Ergin Isil
doaj   +1 more source

Soman induces endoplasmic reticulum stress and apoptosis of cerebral organoids via the GRP78‐ATF6‐CHOP signaling pathway

FEBS Open Bio, EarlyView.
Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei, Zhanbiao Liu, Jingjing Shi, Qian Jin, Wenqian Chen, Xuejun Chen, Liqin Li, Hui Chen   +7 more
wiley   +1 more source

Longitudinal effects of integrated treatment on alcohol use for persons with serious mental illness and substance use disorders [PDF]

, 2000
Sandra E. Herman, Kenneth A. Frank, Carol T. Mowbray, Kurt M. Ribisl, William S. Davidson   +4 more
openalex   +1 more source

Making alcohol and tobacco preventable deaths truly preventable! Addiction as a modifiable risk factor for alcohol and tobacco preventable mortality

Archives of Public Health
Worldwide, health professionals from all specialties are encouraging patients to reduce alcohol use if not abstain, and abstinence is clearly encouraged for tobacco.
Emmanuelle Baillet, Fuschia Serre, Marc Auriacombe   +2 more
doaj   +1 more source

Downregulation of O‐GlcNAcylation enhances etoposide‐induced p53‐mediated apoptosis in HepG2 human liver cancer cells

FEBS Open Bio, EarlyView.
Etoposide, a topoisomerase II inhibitor, reduces O‐GlcNAcylation in HepG2 liver cancer cells. Further inhibition of O‐GlcNAc transferase by OSMI‐1 enhanced etoposide‐induced apoptosis, lowering the IC50 for viability and increasing the EC50 for cytotoxicity.
Jaehoon Lee, Gi‐Bang Koo, Jihye Park, Byung‐Cheol Han, Mijin Kwon, Seung‐Ho Lee   +5 more
wiley   +1 more source

Reddit-Impacts: A Named Entity Recognition Dataset for Analyzing Clinical and Social Effects of Substance Use Derived from Social Media [PDF]

arXiv
Substance use disorders (SUDs) are a growing concern globally, necessitating enhanced understanding of the problem and its trends through data-driven research. Social media are unique and important sources of information about SUDs, particularly since the data in such sources are often generated by people with lived experiences.
arxiv  

FC01.04 Family functioning in the families of patients with bipolar and substance use disorders [PDF]

, 2000
Caroline L. Vandeleur, Martin Preisig, F Ferrero   +2 more
openalex   +1 more source

On subcellular distribution of the zinc finger 469 protein (ZNF469) and observed discrepancy in the localization of endogenous and overexpressed ZNF469

FEBS Open Bio, EarlyView.
ZNF469 regulates the expression of genes encoding extracellular matrix proteins. Endogenous ZNF469 is predominantly cytoplasmic, while in transfected cells, it forms aggregates reminiscent of biomolecular condensates, located mainly in the nucleus. These condensates exhibit overlapping staining with proteasomes and are also associated with the mitotic ...
Anne Elisabeth Christensen Mellgren, Ileana Cristea, Thomas Stevenson, Endy Spriet, Per Morten Knappskog, Stig Ove Bøe, Harald Kranz, Sushma N. Grellscheid, Eyvind Rødahl   +8 more
wiley   +1 more source

Sex-related differences in the prevalence of substance use disorders, treatment, and overdose among parents with young children

Addictive Behaviors Reports, 2023
Introduction: Risk factors and treatment rates for substance use disorders (SUDs) differ by sex. Females often have greater childcare and household responsibilities than males, which may inhibit SUD treatment.
Yitong (Alice) Gao, Elizabeth E. Krans, Qingwen Chen, Scott D. Rothenberger, Kara Zivin, Marian P. Jarlenski   +5 more
doaj