Results 91 to 100 of about 107,326 (259)

Negative symptoms as key features of depression among cannabis users: a preliminary report. [PDF]

, 2016
OBJECTIVE: Cannabis use is frequent among depressed patients and may lead to the so-called "amotivational syndrome", which combines symptoms of affective flattening and loss of emotional reactivity (i.e. the so-called "negative" symptomatology). The aim
Albano, G, BERSANI, FRANCESCO SAVERIO, BERSANI, Giuseppe, Caroti, E, Corazza, O., Imperatori, C, MANUALI, GIORGIANA, MINICHINO, AMEDEO, Russo, P, Valeriani, G   +9 more
core  

CRISPLD2 Attenuates Intervertebral Disc Degeneration by Suppressing Oxidative Stress‐Induced Ferroptosis through the miR‐548I‐IL17A Axis

Advanced Science, EarlyView.
This study identifies CRISPLD2 as a key protector against IVDD. By regulating ferroptosis through the CRISPLD2–miR‐548I–IL17A axis, CRISPLD2 maintains NPCs homeostasis and reduces oxidative stress. Restoring CRISPLD2 expression effectively alleviates disc degeneration and highlights a promising therapeutic strategy for discogenic low back pain ...
Yangyang Shi, Fudong Li, Tianyi Zhao, Kaiqiang Sun, Danying Zhang, Chen Yan, Ximing Xu, Jingchuang Sun, Xulin Hu, Xin Yong, Jiangang Shi, Yuan Wang   +11 more
wiley   +1 more source

A Comparative Study of Clinical Profile, Metabolic Parameters and Outcome of Patient Among Subtypes of Alcohol Dependence Syndrome in Tertiary Level Hospital of Kathmandu Valley

Nepalese Medical Journal, 2019
Introduction: Alcohol is a legally allowed substance used for recreation associated with harmful health consequences both on using it and trying to quit (withdrawal phase).
Prabhakar Pokhrel, Neena Rai, Rajan Pathak, Aajma Thapa, Nishchal Regmi, Pushpa Prasad Sharma   +5 more
doaj   +1 more source

Recent Changes in Drug Abuse Scenario: The Novel Psychoactive Substances (NPS) Phenomenon [PDF]

, 2019
copyright 2019 by the authors. Articles in this book are Open Access and distributed under the Creative Commons Attribution (CC BY) license, which allows users to download, copy and build upon published articles, as long as the author and publisher are ...
Catalani, Valeria, Chilcott, Robert, Corazza, Ornella, Corkery, John, Guirguis, Amira, Marrinan, Shanna, Martinotti, Giovanni, Zloh, Mire   +7 more
core   +3 more sources

CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target

Advanced Science, EarlyView.
This review conceptualizes CD147 as a fundamental “Energy‐Structure Coupler,” physically bridging metabolic flux (via MCTs) with morphogenetic plasticity (via integrins/MMPs) to drive cancer, infection, and autoimmunity. Addressing the “specificity paradox” that limits current translation, the authors chart a strategic roadmap—spanning logic‐gated ...
Xiang‐Min Yang, Huijie Bian, Zhi‐Nan Chen   +2 more
wiley   +1 more source

The (co-)occurrence of problematic video gaming, substance use, and psychosocial problems in adolescents [PDF]

, 2014
Aims. The current study explored the nature of problematic (addictive) video gaming and the association with game type, psychosocial health, and substance use. Methods. Data were collected using a paper and pencil survey in the classroom setting.
Allahverdipour H., Caplan S. E., Cohen J., Cole S. H., Elliott L., Engels R. C. M. E., Evenden J., Ferguson C. J., Fisoun V., Floros G. D., Gentile D. A., Gentile D. A., Ghuman D., Goudriaan A. E., Griffiths M. D., Griffiths M. D., Griffiths M. D., Griffiths M. D., Griffiths M. D., Griffiths M. D., Gross E. F., Grüsser S. M., Han D. H., Hawkins J., Helzer J. E., Kandel D. B., Kandel D. B., Kardefelt-Winther D., Khurana A., King D. L., King D. L., Ko C.-H., Kuss D. J., Kuss D. J., Kuss D. J., La Greca A. M., Lee Y. S., Lemmens J. S., Lemmens J. S., Lortie C. L., Mentzoni R. A., Ng B., Park H. S., Petry N. M., Petry N. M., Rehbein F., Rehbein F., Rosenberg M., Russell D., Shaffer H. J., Sublette V. A., Subrahmanyam K., Sussman S., Valkenburg P. M., van Holst R. J., van Rooij A. J., van Rooij A. J., van Rooij A. J., van Rooij A. J., van Rooij A. J., Verdurmen J., Volberg R. A., Winters K. C., Wisselink D. J., Wood R. T. A., Wood R. T. A.   +65 more
core   +1 more source

A Sirtuin‐1‐Targeted Gene‐Activating Tetrahedral DNA Attenuates Bladder Fibrosis by Restoring Mitophagy in Fibroblasts via the SIRT1‐FOXO3‐BNIP3 Axis

Advanced Science, EarlyView.
The SIRT1‐targeted saRNA‐delivering tetrahedral DNA (TSA) treatment effectively upregulates SIRT1 expression, which subsequently promotes FOXO3A deacetylation. This deacetylation event relieves FOXO3A's transcriptional repression on the BNIP3 gene, thereby initiating PINK1‐PARKIN‐dependent mitophagy.
Wei Wang, Ran Yan, Lede Lin, Lei Xiang, Xiaozhi Xia, Liao Peng, Xiaoshuai Gao, Jiawei Chen, Yang Xiong, Liang Zhou, Yunfeng Lin   +10 more
wiley   +1 more source

The pharmacist’s response to the needs of patients undergoing treatment with psychotropic medication [PDF]

, 1999
The usage of psychotropic (Table 1) medication is considerable world wide. In Malta, this can be attested to by the numerous studies that have been conducted by the University of Malta Department of Pharmacy (in conjuction with other institutions and ...
Sant Fournier, Mary Ann
core  

Patterns of management of patients with dual disorder (psychosis) in Italy: a survey of psychiatrists and other physicians focusing on clinical practice [PDF]

, 2018
© 2018 Clerici, de Bartolomeis, De Filippis, Ducci, Maremmani, Martinotti and Schifano. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).Patients with severe psychotic disorders such as ...
Acquas, Akiskal, Archie, Bacopoulos, Blum, Blum, Bowirrat, Carra, Connelly, Cuomo, De Bartolomeis, De Bartolomeis, Degenhardt, Delisi, Fantini, Fiorillo, Getzen, Gouzoulis-Mayfrank, Grob, Hertzog, Howes, Iasevoli, Kerner, Lambert, Maremmani, Martin, Martinotti, Nesvag, Ostuzzi, Papageorgiou, Regier, Roncero, Rovai, Rubino, Samaha, Samalin, Sugawara, Szkultecka-Debek, Ventriglio, Volkow   +39 more
core   +4 more sources

miR‐135a‐5p Is a Promising Target to Prevent the Glomerulosclerosis Associated with Podocyte Developmental Toxicity in Offspring Induced by Prenatal Dexamethasone Exposure

Advanced Science, EarlyView.
Prenatal dexamethasone exposure (PDE) programs persistent podocyte developmental injury and adult glomerulosclerosis. Mechanistically, glucocorticoid receptor (GR) binds the miR‐135a‐5p promoter and recruits the histone acetyltransferase p300, increasing promoter histone acetylation and sustaining miR‐135a‐5p expression. Elevated miR‐135a‐5p suppresses
Xiaoqi Zhao, Haiyun Chen, Yanan Zhu, Zhiping Xia, Hangyuan He, Yutang Liu, Tianshu Yang, Hui Wang, Ying Ao   +8 more
wiley   +1 more source