Results 71 to 80 of about 1,829,207 (256)

Alcohol Use Disorders: Implications for the Clinical Toxicologist [PDF]

Asia Pacific Journal of Medical Toxicology, 2015
Alcohol use disorders (AUDs) are a health problem of high prevalence in most communities and such problems account for 5% of the total burden of disease worldwide.
Michael McDonough
doaj   +1 more source

Zonisamide versus diazepam in the treatment of alcohol withdrawal syndrome

, 2010
INTRODUCTION: Anticonvulsant drugs have been used in the treatment of alcohol detoxification. The purpose of the present study was to evaluate the efficacy and safety of zonisamide in a sample of patients presenting alcohol withdrawal syndrome ...
Pascual, J.M., M. Á. Jiménez-Arriero, Martínez Gras, Isabel, Álamo González, C, López-Muñoz, F., Ponce, G., G. Rubio, C. Alamo, G. Ponce, I. Martínez-Gras, F. López-Muñoz, Rubio, G., F. Ferre, Jiménez-Arriero, M.A., J. M. Pascual, Ferre, F.   +15 more
core   +1 more source

Arhgef1 Deletion Disrupts Early Cortical Neurogenesis via PAK1 Overactivation and Causes Motor Dysfunction in Adulthood

Advanced Science, EarlyView.
ARHGEF1 plays a pivotal role in both embryonic cortical neurogenesis and adult motor function. During early development, it governs genesis of deep‐layer cortical neurons by negatively regulating RAC1/CDC42‐PAK1‐Cofilin signaling. In adulthood, ARHGEF1 is important for the maintenance of neuronal morphology and activity in the motor cortex, ensuring ...
Liuren Li, Xuanyue Ma, Zhenyu Ding, Bang Sun, Linglin Liu, Hei Matthew Yip, Wei Wang, Tianying Wu, Yuan Guo, Yinghui Peng, Shiqing Zhang, Jacque Pak Kan Ip, Li Zhang, Keshen Li, Lei Shi   +14 more
wiley   +1 more source

European guidelines from the EHTG and ESCP for Lynch syndrome: an updated third edition of the Mallorca guidelines based on gene and gender

BJS (British Journal of Surgery), EarlyView., 2020
Recommendations for clinical and molecular identification of LS, surgical and endoscopic management of LS‐associated colorectal cancer and preventive measures for cancer were produced. The emphasis was on surgical and gastroenterological aspects of the cancer spectrum.
T. T. Seppälä, A. Latchford, I. Negoi, A. Sampaio Soares, R. Jimenez‐Rodriguez, L. Sánchez‐Guillén, D. G. Evans, N. Ryan, E. J. Crosbie, M. Dominguez‐Valentin, J. Burn, M. Kloor, M. von Knebel Doeberitz, F. J. B. van Duijnhoven, P. Quirke, J. R. Sampson, P. Møller, G. Möslein, on behalf of the European Hereditary Tumour Group (EHTG) and European Society of Coloproctology (ESCP)   +18 more
wiley   +1 more source

Stroke‐Heart Syndrome: Mechanisms, Temporal Phenotypes, and Diagnostic Reasoning

Advanced Science, EarlyView.
Stroke‐heart syndrome describes new or worsened cardiac abnormalities after acute stroke. This Review defines its clinical boundaries, traces autonomic, inflammatory, endothelial, and supply‐demand mechanisms across time, and proposes provisional phenotypes that integrate lesion location, premorbid cardiac substrate, serial biomarkers ...
Fa Lin, Jian Lyu, Yanci Liu, Zhiyuan Feng, Jie Bao, Wenxiong Song, Bingcheng Zhu, Minghao Liu, Jionghao Xue, Jiadi Weng, Jiani Zhang, Jizong Zhao, Xiaolin Chen, Bin Dong   +13 more
wiley   +1 more source

[Correction of the symptoms of late substance withdrawal syndrome by intra-conjunctival administration of 5% homatropine solution (preliminary report)].

Psychiatria polska, 1991
The "late" or post-acute alcohol withdrawal syndrome (PAWs) is characterized by recurring waves of psychosomatic disturbances, and return for alcohol for the relief of these symptoms is a commonplace in many of abstinent alcoholics. However, the exact mechanism(s) is not fully known and there is no established any rapid treatment. We now have some data
A, Stojek, J, Madejski, E, Dedelis, K, Janicki   +3 more
openaire   +1 more source

Belly dancer syndrome improved by withdrawal of droxidopa and amantadine

, 2023
Key Clinical Message A man hospitalized for cerebral infarction developed drug‐induced belly dancer syndrome, which improved after withdrawal of droxidopa and amantadine.
Hiroyoshi Ueda, Atsushi Shima, Masashi Oe, Takeshi Ueda, Chika Sunagawa, Nobuyasu Matsukawa, Mihiro Kaga   +6 more
core   +1 more source

A UBE3A‐UTX Proteostasis‐Epigenetic Axis Governs Hypothalamic Energy Homeostasis

Advanced Science, EarlyView.
Ubiquitin protein ligase E3A (UBE3A) regulates hypothalamic energy homeostasis and promotes degradation of the histone demethylase UTX (KDM6A). Neuronal UBE3A loss increases susceptibility to diet‐induced obesity and is accompanied by UTX accumulation, reduced histone H3 lysine 27 trimethylation, and altered endoplasmic reticulum stress‐responsive gene
Junekyoung Lee, Jaeyoung Yoo, Young A. Kim, Zhuodu Wei, Yunseo Lee, Woo‐Jeong Shon, Je Kyung Seong, Seunghee Lee   +7 more
wiley   +1 more source

Alcohol Biomarker Phosphatidylethanol as a Predictor of the Severity of Alcohol Withdrawal Syndrome.

, 2023
AIMS to investigate the relationship between phosphatidylethanol (PEth) and withdrawal severity in patients with alcohol use disorder (AUD). METHODS in 34 patients with AUD admitted for treatment of acute alcohol withdrawal, data were available ...
Novak, Lan, Bünter, Adina, Weinmann, Wolfgang, Stöth, Frederike, Wopfner, Alexander, Pfeifer, Philippe, Soravia, Leila M, Stöth, Frederike Theresa, Soravia, Leila, Frederike Stöth, Alexander Wopfner, Adina Bünter, Lan Novak, Leila M Soravia, Wolfgang Weinmann, Philippe Pfeifer   +15 more
core   +1 more source

A Damage‐Gated Small‐Molecule Chimera Selectively Enhances Mitophagy by Coupling Dysfunctional Mitochondria to Autophagy

Advanced Science, EarlyView.
MG‐1 is a bifunctional small molecule that enhances the removal of damaged mitochondria through autophagy, the cell's recycling pathway. Its activity increases under mitochondrial stress, with minimal effects on basal autophagy. MG‐1 also improves movement in a zebrafish model of mitochondrial dysfunction, supporting further investigation of this ...
Ratislav M. Ozhiganov, Ekaterina А. Guseva, Alexander Yu. Rudenko, Konstantin G. Lyamzaev, Sofya Y. Sokolskaya, Julia A. Golubeva, Maria V. Belopolskaya, Nadezda V. Andrianova, Olga V. Fadeeva, Elena О. Morgun, Elena A. Tukhovskaya, Marina S. Kazakova, Vladimir M. Pavlov, Daria K. Yagoda, Elena I. Marusich, Rose‐Lys Zaranaina, Valeriya B. Vays, Irina M. Vangeli, Egor Y. Plotnikov, Maxim L. Lovat, Lora E. Bakeeva, Arkady N. Murashev, Vladimir I. Polshakov, Olga A. Dontsova, Peter V. Sergiev   +24 more
wiley   +1 more source