Results 51 to 60 of about 1,718,878 (260)

A Magneto‐Mechanically Activated Nerve Guidance Conduit Promotes Peripheral Nerve Regeneration via TIMP1‐Mediated Membrane Tension Transfer

Advanced Functional Materials, EarlyView.
This study presents a magneto‐mechanical strategy that incorporates FP@MSCs into an aligned PCL/GelMA nerve guidance conduit. Magnetic stimulation increases membrane tension in FP@MSCs, triggering cytoskeletal remodeling, Schwann cell‐like differentiation, and TIMP1 secretion. TIMP1 activates ITGB1/CD63–FAK signaling in NE‐4C cells, increasing membrane
Xinyu Zhu, Yumin Wu, Xiang Gao, Tianlu Wang, Wanting Jia, Xueying Mei, Huanzhong Ji, Zongxi Wu, Yujie Liang, Xiang Li, Kan Li, Jingyuan Li, Guangsen Zheng, Guiqing Liao, Siyong Gao   +14 more
wiley   +1 more source

Alcohol Biomarker Phosphatidylethanol as a Predictor of the Severity of Alcohol Withdrawal Syndrome.

, 2023
AIMS to investigate the relationship between phosphatidylethanol (PEth) and withdrawal severity in patients with alcohol use disorder (AUD). METHODS in 34 patients with AUD admitted for treatment of acute alcohol withdrawal, data were available ...
Novak, Lan, Bünter, Adina, Weinmann, Wolfgang, Stöth, Frederike, Wopfner, Alexander, Pfeifer, Philippe, Soravia, Leila M   +6 more
core   +1 more source

2‐Deoxyglucose Dendrimer‐Enabled Niclosamide Delivery to FRβ‐Expressing Macrophages Alleviates Endometriosis Progression and Associated Hyperalgesia

Advanced Healthcare Materials, EarlyView.
A folic acid (FA)‐conjugated 2‐deoxyglucose dendrimer selectively targets FRβ+ macrophages in endometriotic lesions, enabling precise intracellular delivery of niclosamide. This nonhormonal nanomedicine enhances drug solubility, provides controlled intracellular release, suppresses lesion growth, reduces inflammation and pain, and establishes FRβ ...
Anubhav Dhull, Mingxin Shi, Madeleine E. Harvey, Taylor M. Page, Rishi Sharma, Kenneth John Goody, Aqib Iqbal Dar, Nash S. Moawad, Vijay Kumar Sirohi, Paul S. Cooke, Kanako Hayashi, Anjali Sharma   +11 more
wiley   +1 more source

The Use of Benzodiazepines in the Elderly Population: Epidemiology, Risks and Withdrawal Management [PDF]

Eurasian Journal of Family Medicine
Benzodiazepines remain one of the most commonly prescribed medications. Approximately 9% of adults in the United States aged 65 years or above are benzodiazepine users.
Zuzanna Hertz, Szymon Barczak
doaj   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

An interesting presentation of psychotic catatonia in an elderly patient with alcohol dependence

Journal of Geriatric Mental Health, 2019
Catatonia is a neuropsychiatric syndrome with multifactorial etiopathogenesis. It can be seen in patients with alcohol dependence in the context of withdrawal in the presence of comorbid psychiatric disorders (substance induced or independent) or as a ...
Migita Michael Dcruz, Jayant Mahadevan, Prabhat Kumar Chand, Pratima Murthy   +3 more
doaj   +1 more source

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

Advanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang   +5 more
wiley   +1 more source

Appendicitis in a patient with psychiatric problem and drug withdrawal symptoms.

Iranian Journal of Psychiatry, 2010
Physical disorders can be seen in psychiatric patients. In addition, a delayed diagnosis can cause a serious complication of the physical disorder among such patients.
Viroj Wiwanitkit
doaj  

Acute Myocardial Infarction following Naltrexone Consumption; a Case Report

Emergency, 2016
Cardiovascular effects of opioid withdrawal have long been studied. It was reported that patients with underlying ischemic heart disease and atherosclerotic vessels may be complicated by a sudden physical and emotional stress due to withdrawal syndrome ...
Bita Dadpour, Arash Gholoobi, Shahrad Tajoddini, Amir Habibi   +3 more
doaj   +1 more source

Recommendations for analgesia and sedation in critically ill children admitted to intensive care unit

Journal of Anesthesia, Analgesia and Critical Care, 2022
We aim to develop evidence-based recommendations for intensivists caring for children admitted to intensive care units and requiring analgesia and sedation.
Angela Amigoni, Giorgio Conti, Alessandra Conio, Manuela Corno, Paola Claudia Fazio, Federica Ferrero, Marta Gentili, Cristina Giugni, Manuela L’Erario, Maristella Masola, Paola Moliterni, Giuseppe Pagano, Zaccaria Ricci, Stefano Romagnoli, Beatrice Vasile, Francesca Vitale, Geremia Zito Marinosci, Maria Cristina Mondardini   +17 more
doaj   +1 more source