Results 41 to 50 of about 1,829,207 (256)

Morphine versus methadone for neonatal opioid withdrawal syndrome: a randomized controlled pilot study

BMC Pediatrics, 2022
Background Neonatal Opioid Withdrawal Syndrome (NOWS) is a significant public health issue and while millions of neonates are affected each year, an optimal pharmacologic weaning protocol has yet to be demonstrated.
Mary Beth Sutter, Hannah Watson, Nicole Yonke, Sherry Weitzen, Lawrence Leeman   +4 more
doaj   +1 more source

Longitudinal Changes in Adiposity After a Youth Sport‐Related Knee Injury: Informing Posttraumatic Osteoarthritis Prevention

Arthritis Care &Research, EarlyView.
Objective Youth who experience a sport‐related knee injury have elevated odds of becoming overweight or developing obesity in 3 to 10 years, compounding their risk for posttraumatic osteoarthritis (PTOA). To inform prevention strategies, this study compared patterns of adiposity change between youth with a sport‐related knee injury and uninjured youth ...
Justin M. Losciale, Nuria E. J. Jansen, Christina Y. Le, Leo Lu, Hui Xie, Marienke van Middelkoop, Jackie L. Whittaker   +6 more
wiley   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Nursing interventions and assessment tool for neonatal abstinence syndrome (NAS): a case report

Journal of Pediatric and Neonatal Individualized Medicine, 2023
A newborn female was admitted to the Neonatal Intensive Care Unit 2 days after birth with neonatal abstinence syndrome (NAS). The patient displayed withdrawal symptoms from substance misuse, which was passively absorbed in utero via the placenta.
Lorenzo Righi, Alessia Di Gloria, Nicole Brussolo, Fulvia Marini, Stefano Trapassi   +4 more
doaj   +1 more source

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

Advanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang   +5 more
wiley   +1 more source

Toxidrome-based Approach to Common Poisonings [PDF]

Asia Pacific Journal of Medical Toxicology, 2014
Poisoning remains a major cause of hospital admission into the emergency department and intensive care unit. Proper diagnosis is the cornerstone for optimal management of poisoned patients.
Bruno Mégarbane
doaj  

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

Prevalence of alcohol withdrawal symptoms during the Vrischika month among Ayyappa devotees

Bulletin of Faculty of Physical Therapy
Background Alcohol use disorder (AUD) is a critical and escalating global health issue. Alcohol withdrawal symptoms arise when habitual drinkers abruptly discontinue or reduce alcohol intake.
Kaviya Muralidharan, Ramya Arasar, Rajkumar Murugan   +2 more
doaj   +1 more source

Symptomology Associated with in Utero Exposures to Polysubstance in an Appalachian Population

Marshall Journal of Medicine, 2019
Neonatal abstinence syndrome (NAS) is seen as a very high rate at our institution in Huntington, West Virginia, and the majority of exposures are polysubstance in nature. Polysubstance can have different meaning for each region.
Will Lester, Lacey Andrews, Emma M. Nellhaus, Sara Murray, Sean Loudin, Todd H. Davies   +5 more
doaj   +1 more source

Fentanyl versus Methadone in Management of Withdrawal Syndrome in Opioid Addicted Patients; a Pilot Clinical Trial

Archives of Academic Emergency Medicine, 2021
Introduction: The most effective treatment for withdrawal syndrome in Opioid-dependent patients admitted to intensive care units (ICUs) remains unknown. This study aimed to compare fentanyl and methadone in this regard.
Baharak Najafi, Shahin Shadnia, Hossein Hassanian-Moghaddam, Amir Heydarian, Arezou Mahdavinejad, Nasim Zamani   +5 more
doaj   +1 more source