Results 61 to 70 of about 1,829,207 (256)

Acute Myocardial Infarction following Naltrexone Consumption; a Case Report

Emergency, 2016
Cardiovascular effects of opioid withdrawal have long been studied. It was reported that patients with underlying ischemic heart disease and atherosclerotic vessels may be complicated by a sudden physical and emotional stress due to withdrawal syndrome ...
Bita Dadpour, Arash Gholoobi, Shahrad Tajoddini, Amir Habibi   +3 more
doaj   +1 more source

Drug Repurposing for Treating NCOR‐Related Intellectual Disability

Advanced Science, EarlyView.
An autism‐associated NCOR1 heterozygous mutation upregulates NRGs and activates NRG backward signaling in hypothalamic GABAergic neurons in mouse models, leading to Gabra2 downregulation and cognitive deficits, which can be therapeutically targeted by repurposing FDA‐approved drugs.
Yan Kong, Wenjun Zhou, Yuxiang Sun, Zihan Huang, Zhiyue Liu, Udhaya Kumar. S, Chenyan Li, Yi Lu, Chengchuang Song, Veronica C. Ciliberto, Makenna Mack, Lana E. Kim, Zhaoyong Hu, Fang Luo, Aihua Cao, Zheng Sun   +15 more
wiley   +1 more source

A Test of the Social Withdrawal Syndrome

, 2020
A Test of the Social Withdrawal Syndrome Hypothesis of Bulimia ...
Ken Rotenberg
core   +2 more sources

Functional Proteins Involved in Regulation of Intracellular Ca2+ for Drug Development: Chronic Nicotine Treatment Upregulates L-Type High Voltage-Gated Calcium Channels

Journal of Pharmacological Sciences, 2005
Neurochemical mechanisms underlying drug dependence and withdrawal syndrome remain unclear. In this review, we discuss how chronic nicotine exposure to neurons affects expression of diazepam binding inhibitor (DBI), an endogenous anxiogenic neuropeptide ...
Masashi Katsura, Seitaro Ohkuma
doaj   +1 more source

Focus on Clozapine Withdrawal- and Misuse-Related Cases as Reported to the European Medicines Agency (EMA) Pharmacovigilance Database

Brain Sciences, 2020
Background: Clozapine is of high clinical relevance for the management of both treatment-resistant schizophrenia and psychotic disturbances with concurrent drug misuse.
Stefania Chiappini, Fabrizio Schifano, John Martin Corkery, Amira Guirguis   +3 more
doaj   +1 more source

Recommendations for analgesia and sedation in critically ill children admitted to intensive care unit

Journal of Anesthesia, Analgesia and Critical Care, 2022
We aim to develop evidence-based recommendations for intensivists caring for children admitted to intensive care units and requiring analgesia and sedation.
Angela Amigoni, Giorgio Conti, Alessandra Conio, Manuela Corno, Paola Claudia Fazio, Federica Ferrero, Marta Gentili, Cristina Giugni, Manuela L’Erario, Maristella Masola, Paola Moliterni, Giuseppe Pagano, Zaccaria Ricci, Stefano Romagnoli, Beatrice Vasile, Francesca Vitale, Geremia Zito Marinosci, Maria Cristina Mondardini   +17 more
doaj   +1 more source

Mitochondrial Quality Control in Degenerative Musculoskeletal Diseases: Signaling Networks and Therapeutic Landscapes

Advanced Science, EarlyView.
Mitochondrial quality control (MQC) collapse redefines osteoarthritis, intervertebral disc degeneration, and osteoporosis as disorders of organelle dysfunction. Damaged mitochondria leak mtDNA and metabolites, driving cGAS‐STING inflammation, epigenetic reprogramming, and metabolic memory.
Haiyang Gao, Zhangrong Cheng, Xianglong Chen, Wenbo Wu, Wang Wu, Zimu Yu, Cao Yang, Yukun Zhang   +7 more
wiley   +1 more source

Clinical characteristics and short-term outcomes of patients hospitalized with clinically diagnosed withdrawal syndromes: a retrospective observational cohort of 33 patients at a tertiary Poison Control Center in Vietnam

Psychiatry Research Communications
Background: Withdrawal syndromes can range from mild autonomic and neuropsychiatric symptoms to severe complications requiring intensive monitoring and organ support.
Nguyen Dang Duc, Lam Nguyen Hong Khanh
doaj   +1 more source

Effects of Isoniazid on the Acquisition and Expression of Morphine Dependence in Male Mice

Pharmaceutical and Biomedical Research, 2021
Background: GABAergic drugs have extensive interference with morphine’s pharmacological effects, including dependence. Objectives: The present study was conducted to evaluate the effects of isoniazid, a GABAergic agent, on the acquisition and ...
Kamran Shahabi, Amir Abbas Barzegari
doaj  

Czynniki ryzyka majaczenia alkoholowego u osób leczonych stacjonarnie w Polsce z powodu uzależnienia od alkoholu

Alcoholism and Drug Addiction, 2016
Introduction: Delirium tremens (DT) is a life-threatening complication that occurs in 5–33% of patients treated for alcohol withdrawal syndrome. The aim of the present study was to analyse the risk factors for delirium tremens among patients treated for ...
Aneta Michalska, Maciej Kopera, Bartłomiej Gmaj, Agata Łoczewska, Natalia Szejko, Dorota Wołyńczyk-Gmaj, Eliza Kisielińska, Sylwia Fudalej, Marcin Wojnar   +8 more
doaj   +1 more source