Results 61 to 70 of about 1,718,878 (260)
Advanced Science, EarlyView.CR8L10 is self‐assembled with catalase (CAT) to form CR8L10@CAT nanocomplexes, which can anchor to mucosal surfaces via thiol‐disulfide exchange with mucin, thereby enhancing their mucosal retention. The efficient reactive oxygen species (ROS) scavenging at inflamed sites would then result in successful treatment in both the intravesical IC/BPS model ...
Xinzhu Li +13 more
wiley +1 more source
Journal of Pharmacological Sciences, 2005 Neurochemical mechanisms underlying drug dependence and withdrawal syndrome remain unclear. In this review, we discuss how chronic nicotine exposure to neurons affects expression of diazepam binding inhibitor (DBI), an endogenous anxiogenic neuropeptide ...
Masashi Katsura, Seitaro Ohkuma
doaj +1 more source
Brain Sciences, 2020 Background: Clozapine is of high clinical relevance for the management of both treatment-resistant schizophrenia and psychotic disturbances with concurrent drug misuse.
Stefania Chiappini +3 more
doaj +1 more source
Alcohol Use Disorders: Implications for the Clinical Toxicologist [PDF]
Asia Pacific Journal of Medical Toxicology, 2015 Alcohol use disorders (AUDs) are a health problem of high prevalence in most communities and such problems account for 5% of the total burden of disease worldwide.
Michael McDonough
doaj +1 more source
Advanced Science, EarlyView.Large‐scale whole‐exome sequencing in 356,982 UK Biobank participants defines the protein‐coding architecture of retinal structure, visual function, and major blinding diseases. Pleiotropic genes, including CFI, C3, and RIOX1, bridge multiple retinal phenotypes, while experimental validation of FYB2 implicates RPE barrier dysfunction, providing ...
Jianqing Li +23 more
wiley +1 more source
Effects of Isoniazid on the Acquisition and Expression of Morphine Dependence in Male Mice
Pharmaceutical and Biomedical Research, 2021 Background: GABAergic drugs have extensive interference with morphine’s pharmacological effects, including dependence. Objectives: The present study was conducted to evaluate the effects of isoniazid, a GABAergic agent, on the acquisition and ...
Kamran Shahabi, Amir Abbas Barzegari
doaj
Alcoholism and Drug Addiction, 2016 Introduction: Delirium tremens (DT) is a life-threatening complication that occurs in 5–33% of patients treated for alcohol withdrawal syndrome. The aim of the present study was to analyse the risk factors for delirium tremens among patients treated for ...
Aneta Michalska +8 more
doaj +1 more source
Structural Polymorphism of polyG Inclusions Revealed by In Situ Cryo‐Electron Tomography
Advanced Science, EarlyView.Correlative cryo‐electron tomography in primary cortical neurons and NIID mouse brain tissue reveals that polyG inclusions are interconnected ribbon‐like assemblies rather than canonical amyloid fibrils. Multiple compartment‐specific ribbon states show distinct 26S proteasome accessibility, while cytoplasmic ribbons contact and deform ER‐like ...
Yunwen Qian +12 more
wiley +1 more source
A case of neuroleptic malignant syndrome on withdrawal of benzhexol [PDF]
, 2010 The neuroleptic malignant syndrome is a rare and potentially lethal reaction which is usually associated with the use of medications with antidopaminergic properties.
Ferry, Peter +2 more
core
Systematic Multi‐Level Analyses Decode the Arthritis‐Neurodegeneration Axis With In Vivo Validation
Advanced Science, EarlyView.Arthritis and neurodegeneration are usually studied as separate disorders, but this study connects them through population evidence, genetic inference, transcriptomic mapping, and mouse models. It highlights RNF40 as a context‐dependent joint‐brain candidate, induced in inflammatory joints yet functionally linked to dopamine‐neuron vulnerability ...
Jinwen Wang +7 more
wiley +1 more source