Results 171 to 180 of about 137,395 (319)

Utilization of Proteomic Measures for Early Detection of Drug Benefits and Adverse Effects

The Journal of Clinical Pharmacology, EarlyView.
Abstract Recognition of benefits and adverse effects of therapies in earlier clinical trial phases could improve the safety, efficiency, and cost of clinical trials. Using four clinical trials representing a diverse set of diseases and drug classes (EXSCEL: exenatide/GLP‐1 RA, SUGAR‐DM‐HF: empagliflozin/SGLT2i, PRADA: epirubicin/anthracycline, and ...
Jessica Chadwick, Colin Berry, Meredith A. Carpenter, Geeta Gulati, Siri Lagethon Heck, Michael A. Hinterberg, Rury R. Holman, Matthew M.Y. Lee, Torbjørn Omland, Clare Paterson, Mark C. Petrie, Naveed Sattar, Svati H. Shah, Sama Shrestha, Harald Sourij, Emma V Troth, Victoria Vinje, Stephen A. Williams   +17 more
wiley   +1 more source

Emotion and peer problems in autistic adolescents: The role of puberty, school adjustment and bullying

JCPP Advances, EarlyView.
Abstract Background Emotion and peer problems tend to increase in autistic young people during adolescence. However, the extent to which endogenous (e.g., pubertal maturation) and exogenous (e.g., school adjustment, bullying) factors contribute to trajectories of emotion and peer problems in autistic young people is unclear. Methods Using data from the
Erin O. Dawe‐Lane, Rob Saunders, Eirini Flouri, William P. L. Mandy   +3 more
wiley   +1 more source

Mothers with Concurrent Opioid and Cocaine Use and Neonatal Opioid Withdrawal Syndrome. [PDF]

Children (Basel)
Rana D, DeBaer L, Pourcyrous M.
europepmc   +1 more source

A case of idiosyncratic drug‐induced agranulocytosis because of sulbactam/ampicillin

Journal of General and Family Medicine, EarlyView.
We report a case of agranulocytosis caused by sulbactam/ampicillin. During antimicrobial therapy, close monitoring of total white blood cell counts is essential. Abstract Idiosyncratic drug‐induced agranulocytosis is a rare but life‐threatening condition that requires immediate medical intervention.
Kazuya Toda, Kaku Kuroda, Moe Kuroda, Kota Kawai, Yukihiro Sato   +4 more
wiley   +1 more source

Prognostic Impact of Unplanned Total Pancreatectomy in Pancreatic Ductal Adenocarcinoma: A Retrospective Analysis

Journal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Background This study evaluated the clinical significance of an unplanned total pancreatectomy (TP) by comparing surgical outcomes of planned and unplanned TP for pancreatic ductal adenocarcinoma (PDAC). Methods Forty‐two patients who underwent TP for PDAC between 2009 and 2020 at the Kindai University Hospital were retrospectively analyzed ...
Dongha Lee, Keiko Kamei, Chihoko Nobori, Yuta Yoshida, Takaaki Murase, Atsushi Takebe, Takuya Nakai, Mamoru Takenaka, Takaaki Chikugo, Ippei Matsumoto   +9 more
wiley   +1 more source

The core competencies in hospital medicine: Procedures 2025 update

Journal of Hospital Medicine, EarlyView.
Abstract This article presents an updated framework from the Society of Hospital Medicine for individual learning objectives related to key procedures in hospital medicine. Building upon the 2017 framework, these objectives have been revised to reflect evolving clinical evidence, advancements, and shifts in hospital medicine practice patterns.
Satyen Nichani, Megan E. Brooks, Christine Bryson, Nick Fitterman, Meltiady Issa, Michael Lukela, Nick Marzano, Kelly Sopko, Joseph R. Sweigart   +8 more
wiley   +1 more source

The Identification and Challenges of Dopamine Dysregulation Syndrome: A Case Report. [PDF]

Cureus
Sulaiman A, Leppla I.
europepmc   +1 more source

Randomized clinical trial evaluating kinetic benefits of desensitizing agents: Magnitude, onset, and stability of relief

Journal of Periodontology, EarlyView.
Abstract Background Dentin hypersensitivity (DH) is common, particularly among periodontal patients. This trial evaluated magnitude of desensitizing benefit, onset of action, and complete relief of three dentifrices with distinct desensitizing technologies.
Aaron R. Biesbrock, Tao He, Yuanshu Zou, Julie M. Grender, Pejmon Amini, Paul A. Sagel, Andrew Groth, Malgorzata Klukowska   +7 more
wiley   +1 more source

Applying a Modified Version of the Prediction of Alcohol Withdrawal Severity Scale in a Canadian Community Withdrawal Management Setting. [PDF]

Drug Alcohol Rev
Crepeault H, Cowan N, Socias ME, Riazi N, Knill A, Khela A, Wood E, Ti L.   +7 more
europepmc   +1 more source

Management of paediatric ulcerative colitis, part 1: Ambulatory care—An updated evidence‐based consensus guideline from the European Society of Paediatric Gastroenterology, Hepatology and Nutrition and the European Crohn's and Colitis Organisation

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Despite advances in the management of ambulatory paediatric ulcerative colitis (UC), challenges remain as many patients are refractory to therapy and some require colectomy. The aim of these guidelines is to provide an update on optimal care for UC through detailed recommendations and practice points. Methods These guidelines are an
Eytan Wine, Marina Aloi, Stephanie Van Biervliet, Jiri Bronsky, Javier Martín di Carpi, Marco Gasparetto, Laura Gianolio, Hannah Gordon, Iva Hojsak, Alexandra S. Hudson, Séamus Hussey, Johan van Limbergen, Erasmo Miele, Lorenzo Norsa, Ola Olén, Gianluca Pellino, Patrick van Rheenen, Lissy de Ridder, Richard K. Russell, Dror S. Shouval, Eunice Trindade, Dan Turner, David C. Wilson, Anat Yerushalmy Feler, Amit Assa   +24 more
wiley   +1 more source