Results 51 to 60 of about 123,595 (337)

Advanced MRI-based evaluation of gray and white matter changes in Parkinson’s disease

The Egyptian Journal of Radiology and Nuclear Medicine
Background Parkinson’s disease (PD) is the most common movement disorder and the second most common neurodegenerative disease. The aim of our study was to compare gray–white matter changes (GWC) between Parkinson's disease (PD) patients and age-matched ...
Mohamed Mohsen, Nehal Aboubakr Elsayed Mohamed, Abdelhalim El-Tantawy Mohamed Bedir, Ahmed Abdel Khalek Abdel Razek, Ahmed Effat Abbas Mohamed Saied   +4 more
doaj   +1 more source

Generation of Neural Organoids and Their Application in Disease Modeling and Regenerative Medicine

Advanced Science, EarlyView.
Neural organoids provide a versatile platform for neurological research. Advances in organoid technology have partially achieved human neural tissue complexity in terms of tissue structure, cell diversity, and neural signaling, offering insights into neural disorders and regenerative strategies. Technology advances from biomaterials, bio‐manufacturing,
Ruiqi Huang, Feng Gao, Liqun Yu, Haokun Chen, Rongrong Zhu   +4 more
wiley   +1 more source

Human Induced Pluripotent Stem Cells Improve Stroke Outcome and Reduce Secondary Degeneration in the Recipient Brain

Cell Transplantation, 2012
Human induced pluripotent stem cells (hiPSCs) are a most appealing source for cell replacement therapy in acute brain lesions. We evaluated the potential of hiPSC therapy in stroke by transplanting hiPSC-derived neural progenitor cells (NPCs) into the ...
Jérôme Polentes, Pavla Jendelova, Michel Cailleret, Holger Braun, Nataliya Romanyuk, Philippe Tropel, Marion Brenot, Valerie Itier, Christine Seminatore, Kathrin Baldauf, Karolina Turnovcova, Daniel Jirak, Marius Teletin, Julien Côme, Johana Tournois, Klaus Reymann, Eva Sykova, Stéphane Viville, Brigitte Onteniente   +18 more
doaj   +1 more source

Identification of proteins in human substantia nigra [PDF]

PROTEOMICS – Clinical Applications, 2008
AbstractCharacterization of the human brain proteome is a critical area of research. While examination of the human cortex has provided some insight, very little is known about the proteome of the human midbrain, which demonstrates substantial loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) in Parkinson's disease (PD ...
Kitsou, Efstathia, Pan, Sheng, Zhang, Jian Peng, Shi, Min, Zabeti, Aram, Dickson, Dennis W., Albin, Roger L., Gearing, Marla, Kashima, Daniel T., Wang, Yan, Beyer, Richard P., Zhou, Yong, Pan, Catherine, Caudle, W. Michael, Zhang, Jing   +14 more
openaire   +4 more sources

Functional Dopaminergic Neurons in Substantia Nigra are Required for Transcranial Magnetic Stimulation-Induced Motor Plasticity.

Cerebral Cortex, 2015
Repetitive magnetic stimulation (rTMS), including theta burst stimulation (TBS), is capable of modulating motor cortical excitability through plasticity-like mechanisms and might have therapeutic potential for Parkinson's disease (PD).
T. Hsieh, Ying-Zu Huang, A. Rotenberg, Á. Pascual-Leone, Y. Chiang, Jia-Yi Wang, J. Chen   +6 more
semanticscholar   +1 more source

Neuronal FGF13 Inhibits Mitochondria‐Derived Damage Signals to Prevent Neuroinflammation and Neurodegeneration in a Mouse Model of Parkinson's Disease

Advanced Science, EarlyView.
This study elucidates a novel role of FGF13 in manipulating neuronal fate via mitochondrial transfer. FGF13 is identified as a mitochondria‐stabilizing protein by interacting with mitochondrial proteins. Under stress, the decrease of neuronal FGF13 fails to retain mitochondria within the cytoplasm, leading to the release of damaged mitochondria to ...
Nanshan Song, Xiangxu Wang, Luqing Ha, Lamei Hu, Shuyuan Mei, Yue Liang, Yujie Zhao, Xingyin Yang, Qingyu Zhang, Yuanzhang Zhou, Jianhua Ding, Yan Liu, Qigang Zhou, Feng Han, Gang Hu, Ming Lu   +15 more
wiley   +1 more source

Depth‐Customizable 3D Electrode Array for Recording Functional Connectivity in the Brain

Advanced Electronic Materials, EarlyView.
In this study, a depth‐adjustable, flexible 3D multi‐shank electrode array that produces precise neural recordings at various brain depths is developed. Integrating 2D flexible electrode arrays with a modular supporting board allowed the insertion depth to be easily adjusted without re‐fabrication.
Minseok Kim, Sehwan Park, Haeyun Lee, Jimin Lee, Namsun Chou, Hyogeun Shin   +5 more
wiley   +1 more source

Dopaminergic neurodegeneration in the substantia nigra is associated with olfactory dysfunction in mice models of Parkinson’s disease

Cell Death Discovery, 2023
Olfactory dysfunction represents a prodromal stage in Parkinson’s disease (PD). However, the mechanisms underlying hyposmia are not specified yet.
Yu Yuan, Xizhen Ma, Xiaoqing Mi, Le Qu, Meiyu Liang, Mengyu Li, Youcui Wang, Ning Song, Junxia Xie   +8 more
doaj   +1 more source

A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

Proceedings of the National Academy of Sciences of the United States of America, 1983
A syndrome similar to idiopathic parkinsonism developed after intravenous self-administration of an illicit drug preparation in which N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (NMPTP) might have been responsible for the toxicity.
Burns Rs, C. Chiueh, S. Markey, M. Ebert, D. Jacobowitz, I. Kopin   +5 more
semanticscholar   +1 more source

New MRI diagnostic methods in Parkinson's disease: evaluating nigral degeneration

Анналы клинической и экспериментальной неврологии, 2019
Research Center of Neurology, Moscow, Russia Parkinson's disease (PD) is a progressive neurodegenerative disorder with a characteristic pathological hallmark of loss of the dopaminergic neurons in the compact part of the substantia nigra in the ...
Sergey N. Illarioshkin, Rodion N. Konovalov, Ekaterina Yu. Fedotova, Anna N. Moskalenko   +3 more
doaj   +1 more source