Results 61 to 70 of about 86,799 (302)

640-Slice CT Measurement of Superior Orbital Fissure as Gateway for Light into the Brain: Statistical Evaluation of Area and Distance. [PDF]

PLoS ONE, 2016
OBJECTIVE:Our aim was to provide normative data concerning superior orbital fissure area (SOFA), ocular skin and the substantia nigra (D-SS) and orbital fissure and the substantia nigra (D-SOF-S) distances by CT scan in adult Caucasian population ...
Alice La Marra, Simone Quarchioni, Fabiana Ferrari, Giovanni Luca Gravina, Antonio Barile, Lorenzo Maria Gregori, Ernesto Di Cesare, Alessandra Splendiani   +7 more
doaj   +1 more source

PRMT9 Aggravated Dopaminergic Neurodegeneration in Parkinson's Disease Model by Facilitating the Degradation of DUSP26 and Inducing Mitochondrial Dysfunction

Advanced Science, EarlyView.
In the pathological state of PD induced by MPP+, the upregulated PRMT9 in dopaminergic neurons translocates into mitochondrion and interacts with DUSP26 and catalyzes its arginine methylation, leading to the ubiquitin‐proteasomal degradation of DUSP26 mediated by Trim32.
Tengfei Liu, Xiaomeng Song, Xin Guo, Rui Xiao, Ru Sun, Qiuran Ji, Lu Yu, Yiquan Li, Qingyi Fu, Qidi Xue, Lingjun Kong, Lin Chen, Chengjiang Gao, Huiqing Liu   +13 more
wiley   +1 more source

Expanded Hepatic Progenitor Cells Featured with Aggregation of α‐Synuclein Contribute to Pathologic Bile Duct Regeneration in Biliary Atresia

Advanced Science, EarlyView.
Expanded NCAM1+EpCAM+ hepatic progenitor cells in biliary atresia are characterized by aggregation of α‐synuclein. This pathological protein potentiates cellular susceptibility to GSH‐dependent redox dyshomeostasis, induces unstable biliary cell fate specification, and subsequently drives aberrant biliary regeneration.
Hua Xie, Mengyan Zhu, Zhongxian Zhu, Jiaqi Tang, Ruyi Zhang, Zequan Ding, Junzhi Li, Zhongluan Wu, Paul Kwong Hang Tam, Qianghu Wang, Vincent Chi Hang Lui, Yankai Xia, Weibing Tang   +12 more
wiley   +1 more source

Pontomedullary reticular formation neurones : a study of microanatomy, transmitter sensitivity and connections from the substantia nigra pars reticulata

, 1990
Bibliography: leaves 164-200.This investigation examines certain aspects of the medial pontomedullary reticular formation (PMRF) microanatom y and neurotransmission and also the connections between the substantia nigra pars reticulata (SNr) and the PMRF ...
Kellaway, Lauriston Arthur
core  

Gene Correction Enhances Dopaminergic Cell Therapy in a Nonhuman Primate Model of Parkinson's Disease

Advanced Science, EarlyView.
LRRK2‐mutant induced pluripotent stem cells (iPSCs) were derived from a patient with Parkinson's disease (PD). Using CRISPR/Cas9–mediated gene editing, the pathogenic LRRK2 mutations were precisely corrected, and isogenic dopaminergic neural progenitor cells (DA‐NPCs) were subsequently generated.
Qing Yan, Chongchong Xu, Jiangmei Gao, Pu Wang, Qingling Wu, Ying Jin, Binyan Lu, Mu Li, Mingting Shao, Bihai Li, Zhenghui Su, Yijng Zhang, Jianhuan Chen, Haojie An, Mengyao Huang, Xiaoji Zhuang, Yuhui Shen, Fenglin Wang, Nana Xu, Yiyan Liu, Lei Tang, Xiuling Zhong, Minyan Zhong, Jiecong Chen, Zhenhuang Wang, Xingrong Luo, Sheng Liu, RuiFeng Liu, Ling Zhang, Junhua Rao   +29 more
wiley   +1 more source

The Role of Opioids on Motor Activity in Physio-pathological Conditions

, 2009
To date, four principal classes of opioid peptide receptors, μ (MOP), κ (KOP), δ (DOP) and ORL- 1 (NOP) have been identified and cloned. The experimental and clinical importance of this receptor family has been amply demonstrated in many diseases ...
Mabrouk, Omar Sharif
core  

Dopamine uptake between striatum and substantia nigra.

, 2013
The inherent differences in DA uptake between striatum and substantia nigra in non-lesioned tissue, as per our synaptosome preparation and uptake protocol are illustrated. Our results reflect the previous observations that DAT expression is significantly
Deana M. Apple (292371), Michael F. Salvatore (255748), Tanya Chotibut (292370), Rebecca Jefferis (184983)   +3 more
core   +1 more source

AAV-mediated intracerebral expression of an α-synuclein-targeting intrabody improves motor functions in aged rats

Scientific Reports
Abnormal accumulation of alpha-synuclein (αSyn) in axons and presynaptic terminals plays a critical role in αSyn-mediated dopaminergic neurodegeneration.
Kuo-Jen Wu, Yu-Sung Chiu, Seong-Jin Yu, Yu-Syuan Wang, Chun-Tien Chen, Yu-Chen Peng, Yao-Ming Chuang, Chia-Ying Chu, Yin-Chia Li, Kun-Liang Wang, Shu-Ching Hsu, Yun-Hsiang Chen   +11 more
doaj   +1 more source

Identification of senescence‐related genes in Parkinson's disease reveals candidate therapeutic targets and pathological processes

Animal Models and Experimental Medicine, EarlyView.
At the genomic level, a large number of differentially expressed genes (DEGs) and aging‐related DEGs have been screened. Ten hub genes, such as IFNγ and IRF7, have been identified and shown potential value in the diagnosis of PD, holding promise as novel biomarkers to facilitate early and precise diagnosis.
Haojie Wu, Tingting Liu, Xiangshu Cheng, Jianshe Wei   +3 more
wiley   +1 more source

Metabolic effects of unilateral lesion of the substantia nigra

, 1981
Regional brain glucose utilization following unilateral lesion of the substantia nigra in rat was studied by [14C]-2-deoxyglucose autoradiography. Substantia nigra lesions were performed by perinigral injections of 6-hydroxydopamine (6-OHDA) .
RC Collins, GF Wooten
core   +1 more source