Results 61 to 70 of about 129,849 (338)

Review of Multifunctional Neural Probe

Advanced Materials Interfaces, EarlyView.
Modern multifunctional neural probes for brain‐machine interfaces extend beyond basic electrical functions to incorporate chemical and optical modalities. This review explores recent advances in multifunctional probes developed for neural signal acquisition and stimulation, highlighting how these innovations enhance the precision of brain activity ...
Ziqi Jia, Yong Kyu Yoon
wiley   +1 more source

AAV Vector-Mediated Gene Delivery to Substantia Nigra Dopamine Neurons : Implications for Gene Therapy and Disease Models [PDF]

, 2017
Gene delivery using adeno-associated virus (AAV) vectors is a widely used method to transduce neurons in the brain, especially due to its safety, efficacy, and long-lasting expression.
Airavaara, Mikko, Albert, Katrina, Domanskyi, Andrii, Voutilainen, Merja H.   +3 more
core   +2 more sources

Implantable Nongenetic Optoelectronic Biointerfaces for Neuromodulation

Advanced Photonics Research, EarlyView.
This review summarizes recent advances in semiconductor‐based optoelectronic biointerfaces for wireless, optically induced electrical neuromodulation. It highlights their diverse designs that enable precise, targeted neural modulation of cells, tissues, and organs.
Jinglin Ye, Jinwei Huang, Wenyu Nie, Jianming Xu, Xing Sheng, Huachun Wang   +5 more
wiley   +1 more source

Human Induced Pluripotent Stem Cells Improve Stroke Outcome and Reduce Secondary Degeneration in the Recipient Brain

Cell Transplantation, 2012
Human induced pluripotent stem cells (hiPSCs) are a most appealing source for cell replacement therapy in acute brain lesions. We evaluated the potential of hiPSC therapy in stroke by transplanting hiPSC-derived neural progenitor cells (NPCs) into the ...
Jérôme Polentes, Pavla Jendelova, Michel Cailleret, Holger Braun, Nataliya Romanyuk, Philippe Tropel, Marion Brenot, Valerie Itier, Christine Seminatore, Kathrin Baldauf, Karolina Turnovcova, Daniel Jirak, Marius Teletin, Julien Côme, Johana Tournois, Klaus Reymann, Eva Sykova, Stéphane Viville, Brigitte Onteniente   +18 more
doaj   +1 more source

Quantitative elemental bio-imaging of Mn, Fe, Cu and Zn in 6-hydroxydopamine induced Parkinsonism mouse models [PDF]

, 2009
This study demonstrates the application of quantitative elemental bio-imaging for the determination of the distribution Cu, Mn, Fe and Zn in Parkinsonism mouse model brains.
Bush, AI, Cherny, RA, Doble, P, Finkelstein, DI, George, JL, Grimm, R, Hare, D, Reedy, B, Volitakis, I, Wilkins, S   +9 more
core   +1 more source

The GLP1R Agonist Semaglutide Inhibits Reactive Astrocytes and Enhances the Efficacy of Neural Stem Cell Transplantation Therapy in Parkinson's Disease Mice

Advanced Science, EarlyView.
Compared to transplantation of neural stem cells (NSCs) alone, the combined treatment of NSCs with semaglutide more effectively improves motor dysfunction in Parkinson's disease (PD) mice. This synergistic effect may result from semaglutide's ability to suppress microglial activation, thereby preventing the transformation of resting astrocytes into ...
Dan Song, Xiaoya Zou, Di Ma, Yuying Zhao, Tingting Liu, Bibiao Shen, Oumei Cheng   +6 more
wiley   +1 more source

MRI Epicenters Differentiate Spatiotemporal Patterns of Neurodegeneration in Parkinson's Disease

Advanced Science, EarlyView.
A connectivity‐based MRI epicenter model identifies two Parkinson's disease subtypes: subtype 1 with infratentorial‐dominant epicenters, severe motor symptoms, and rapid progression; and subtype 2 with supratentorial‐dominant epicenters with mild progression.
Xiaojie Duanmu, Zihao Zhu, Jiaqi Wen, Jianmei Qin, Qianshi Zheng, Weijin Yuan, Yingni Jin, Nan Lu, Lu Wang, Cheng Zhou, Tao Guo, Haoting Wu, Chenqing Wu, Ziyi Zhu, Lifang Wang, Jingwen Chen, Jingjing Wu, Bingting Zhu, Yuelin Fang, Yaping Yan, Baorong Zhang, Minming Zhang, Xiaojun Guan, Xiaojun Xu   +23 more
wiley   +1 more source

Dopaminergic neurodegeneration in the substantia nigra is associated with olfactory dysfunction in mice models of Parkinson’s disease

Cell Death Discovery, 2023
Olfactory dysfunction represents a prodromal stage in Parkinson’s disease (PD). However, the mechanisms underlying hyposmia are not specified yet.
Yu Yuan, Xizhen Ma, Xiaoqing Mi, Le Qu, Meiyu Liang, Mengyu Li, Youcui Wang, Ning Song, Junxia Xie   +8 more
doaj   +1 more source

Identification of proteins in human substantia nigra [PDF]

PROTEOMICS – Clinical Applications, 2008
AbstractCharacterization of the human brain proteome is a critical area of research. While examination of the human cortex has provided some insight, very little is known about the proteome of the human midbrain, which demonstrates substantial loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) in Parkinson's disease (PD ...
Kitsou, Efstathia, Pan, Sheng, Zhang, Jian Peng, Shi, Min, Zabeti, Aram, Dickson, Dennis W., Albin, Roger L., Gearing, Marla, Kashima, Daniel T., Wang, Yan, Beyer, Richard P., Zhou, Yong, Pan, Catherine, Caudle, W. Michael, Zhang, Jing   +14 more
openaire   +4 more sources

Nanozymes for Non‐Neoplastic Diseases: Catalytic Therapy Redefined

Aggregate, EarlyView.
Non‐neoplastic diseases pose a significant health burden. Nanozymes, enzyme‐like nanomaterials, offer promising strategies for regulating oxidative stress and inflammation. This review explores their development, structure–function relationships, and therapeutic potential, with a focus on precision medicine through targeted delivery and multimodal ...
Ling Mei, Xikai Wang, Zhuang Hu, Jierui Yan, Xiaobo Wang, Haoran Wang, Ya Hou, Pengfei Zhang, Qihang Ding   +8 more
wiley   +1 more source