Results 61 to 70 of about 71,981 (295)

Differences in brain pathological changes between rotenone and 6-hydroxydopamine Parkinson’s disease models

Neural Regeneration Research, 2018
Rotenone and 6-hydroxydopamine are two drugs commonly used to generate Parkinson’s disease animal models. They not only achieve degenerative changes of dopaminergic neurons in the substantia nigra, but also satisfy the requirements for iron deposition ...
Lan-Xiang Liu, Dan Du, Zhan-Qiu Wang, Yuan Fang, Tao Zheng, Yan-Chao Dong, Qing-Lei Shi, Min Zhao, Fang Xiao, Juan Du   +9 more
doaj   +1 more source

Intense exercise increases dopamine transporter and neuromelanin concentrations in the substantia nigra in Parkinson’s disease

npj Parkinson's Disease
Parkinson’s disease (PD) is characterized by a progressive loss of dopaminergic neurons. Exercise has been reported to slow the clinical progression of PD.
Bart de Laat, Jocelyn Hoye, Gelsina Stanley, Michelle Hespeler, Jennifer Ligi, Varsha Mohan, Dustin W. Wooten, Xiaomeng Zhang, Thanh D. Nguyen, Jose Key, Giulia Colonna, Yiyun Huang, Nabeel Nabulsi, Amar Patel, David Matuskey, Evan D. Morris, Sule Tinaz   +16 more
doaj   +1 more source

Intracerebroventricularly-administered 1-methyl-4-phenylpyridinium ion and brain-derived neurotrophic factor affect catecholaminergic nerve terminals and neurogenesis in the hippocampus, striatum and substantia nigra

Neural Regeneration Research, 2018
Parkinson's disease is a progressive neurological disease characterized by the degeneration of dopaminergic neurons in the substantia nigra. A highly similar pattern of neurodegeneration can be induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine ...
Jun-Fang Chen, Man Wang, Ying-Han Zhuang, Thomas Behnisch   +3 more
doaj   +1 more source

Probing the Inhibitory Potential of Halogenated Symmetrical Formamidine Against MAO‐A and MAO‐B: Structural Elucidation, Molecular Dynamic Simulation and DFT Computational Studies

Chemistry &Biodiversity, EarlyView.
ABSTRACT A halogenated symmetrical formamidine, N,N′‐bis(3‐chloro‐4‐fluorophenyl)formamidine (FCF) was synthesized by the condensation reaction between triethyl orthoformate and 3‐chloro‐4‐fluoroaniline in 1:2 ratio. The compound FCF was characterized by FT‐IR, mass, NMR (1H and 13C) spectroscopic techniques and the purity was confirmed by elemental ...
Segun D. Oladipo, Robert C. Luckay, Samuel O. Olalekan, Abosede A. Badeji, Tunde L. Yusuf, Adesola A. Adeleke, Nonkosi Matinise   +6 more
wiley   +1 more source

Distribution and Modulation of Histamine H3 Receptors in Basal Ganglia and Frontal Cortex of Healthy Controls and Patients with Parkinson's Disease

Neurobiology of Disease, 2001
Parkinson's disease (PD) is a brain degenerative disorder with unknown etiology, and specific degeneration of mesencephalic dopaminergic cells is a morphological manifestation of the disease. The central histaminergic system appears to be activated in PD,
Oleg V. Anichtchik, Nina Peitsaro, Juha O. Rinne, Hannu Kalimo, Pertti Panula   +4 more
doaj  

Neuroprotective Effect of Ghrelin on Substantia Nigra in Parkinson Disease Model Induced -MPTP [PDF]

بیولوژی کاربردی, 2019
Aim and Background: Parkinson's disease is a progressive central nervous system disorder. This disease is caused by degenerative loss of dopaminergic neurons of midbrain, from substantia nigra to corpus striatum pathway.
Neda Nikoklam Nazif
doaj  

Manganese Neurotoxicity and Familial Disorders of Manganese Transport

Annals of the Child Neurology Society, EarlyView.
ABSTRACT Manganese is the 12th most common element in the Earth's crust and is an essential industrial component. Biologically, this metal plays an important role as a constituent of numerous enzymes. While manganese is required for normal biochemical and physiological processes, manganese excess can lead to significant toxicity, particularly to the ...
Sidney M. Gospe Jr.
wiley   +1 more source

Restricted effects of androgens on glucocorticoid signaling in the mouse prefrontal cortex and midbrain

Frontiers in Endocrinology
Glucocorticoids are key executors of the physiological response to stress. Previous studies in mice showed that the androgen receptor (AR) influenced the transcriptional outcome of glucocorticoid treatment in white and brown adipocytes and in the liver ...
Jorge Miguel Amaya, Jorge Miguel Amaya, Hetty C. M. Sips, Hetty C. M. Sips, Eva M. G. Viho, Eva M. G. Viho, Jan Kroon, Jan Kroon, Onno C. Meijer, Onno C. Meijer   +9 more
doaj   +1 more source

Quantitative Susceptibility Mapping in Parkinson's Disease.

PLoS ONE, 2016
BackgroundQuantitative susceptibility mapping (QSM) and R2* relaxation rate mapping have demonstrated increased iron deposition in the substantia nigra of patients with idiopathic Parkinson's disease (PD).
Christian Langkammer, Lukas Pirpamer, Stephan Seiler, Andreas Deistung, Ferdinand Schweser, Sebastian Franthal, Nina Homayoon, Petra Katschnig-Winter, Mariella Koegl-Wallner, Tamara Pendl, Eva Maria Stoegerer, Karoline Wenzel, Franz Fazekas, Stefan Ropele, Jürgen Rainer Reichenbach, Reinhold Schmidt, Petra Schwingenschuh   +16 more
doaj   +1 more source

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source