Results 91 to 100 of about 810,832 (336)
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Substrate Specificity and Enzyme Recycling Using Chitosan Immobilized Laccase
Molecules, 2014 The immobilization of laccase (Aspergillus sp.) on chitosan by cross-linking and its application in bioconversion of phenolic compounds in batch reactors were studied.
Everton Skoronski +6 more
doaj +1 more source
Communications Biology, 2023 Engineering of transporters to alter substrate specificity as desired holds great potential for applications, including metabolic engineering. However, the lack of knowledge on molecular mechanisms of substrate specificity hinders designing effective ...
Yuhan Jiang +8 more
doaj +1 more source
Nucleotide specificity of the enzymatic and motile activities of dynein, kinesin, and heavy meromyosin. [PDF]
, 1991 The substrate specificities of dynein, kinesin, and myosin substrate turnover activity and cytoskeletal filament-driven translocation were examined using 15 ATP analogues.
Furusawa, K +6 more
core +2 more sources
Substrate specificity of bleomycin hydrolase
Biochemical Pharmacology, 1989 Bleomycin (BLM) hydrolase is believed to protect both malignant and normal tissue from the toxicity of the antitumor drug BLM. Little is known about the substrate specificity of BLM hydrolase. Thus, we developed ion-paired reverse phase high speed liquid chromatography systems to assay for the metabolism of several BLM analogs.
S M, Sebti +4 more
openaire +2 more sources
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Robustness and modularity properties of a non-covalent DNA catalytic reaction [PDF]
, 2009 The biophysics of nucleic acid hybridization and strand displacement have been used for the rational design of a number of nanoscale structures and functions. Recently, molecular amplification methods have been developed in the form of non-covalent DNA
Aldaye +20 more
core +4 more sources
Substrate Specificity of Trypanothione Reductase [PDF]
European Journal of Biochemistry, 1997 Trypanothione redutase, one of the family of flavin‐dependent disulfide oxidoreductases, catalyses the reduction of trypanothione disulfide [N1,N8‐bis(glutathionyl)spermidine] and related glutathionyl‐polyamine disulfides. A series of subtly different, designed substrate analogues based on trypanothione were prepared by means of a solid‐phase approach ...
I R, Marsh, M, Bradley
openaire +2 more sources
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Chemical patterning for the highly specific and programmed assembly of nanostructures [PDF]
, 2005 We have developed a new chemical patterning technique based on standard lithography-based processes to assemble nanostructures on surfaces with extraordinarily high selectivity.
Alivisatos +12 more
core +1 more source