Results 91 to 100 of about 660,873 (335)
Molecular Oncology, EarlyView.Tumor microenvironment drives cancer formation and progression. We analyzed the role of human cancer‐associated adipocytes from patients with renal cell carcinoma (RCC) stratified as lean, overweight, or obese. RNA‐seq demonstrated that, among the most altered genes involved in the tumor–stroma crosstalk, are ADAM12 and CYP1B1, which were proven to be ...
Sepehr Torabinejad +13 more
wiley +1 more source
The substrate specificity of carnitine acetyltransferase [PDF]
Biochemical Journal, 1967 1. A study of the acyl group specificity of the carnitine acetyltransferase reaction [acyl-(-)carnitine+CoASH right harpoon over left harpoon (-)-carnitine+acyl-CoA] has been made with the enzyme from pigeon breast muscle. Acyl groups containing up to 10 carbon atoms are transferred and detailed kinetic investigations with a range of acyl-CoA and ...
openaire +3 more sources
Frustration of nanoconfined liquid crystals due to hybrid substrate anchoring [PDF]
arXiv, 2010 We present Monte Carlo simulations of liquid-crystalline material confined to a nanoscopic slit-pore. The simulations are carried out under isothermal conditions in a specialized isostress ensemble in which N fluid molecules are exposed to a compressional stress acting on the fluid in directions parallel with the substrate planes. Fluid-fluid and fluid-
arxiv
Targeted metabolomics reveals novel diagnostic biomarkers for colorectal cancer
Molecular Oncology, EarlyView.This study employed targeted metabolomic profiling to identify 302 distinct metabolites present in platelet‐rich plasma (PRP), revealing aberrant metabolic profiles amongst individuals diagnosed with colorectal cancer (CRC). Compared to carcinoembryonic antigen (CEA) and cancer antigen 19‐9 (CA199), our metabolite panel showed improved sensitivity ...
Zuojian Hu +7 more
wiley +1 more source
SUBSTRATE SPECIFICITY OF ВACILLUS THURINGIENSIS IМV В-7324 PEPTIDASE 2
Mìkrobìologìâ ì Bìotehnologìâ, 2013 Ai m. Investigation of substrate specificity of the purified peptidase 2 from Вacillus thuringiensis IМV В-7324. Methods. To study the substrate specificity of the peptidase 2 we used protein: elastin, fibrin, fibrinogen, collagen and casein ...
Н. А. Нідялкова +2 more
doaj +1 more source
Taking Advantage of Promiscuity of Cold-Active Enzymes
Applied Sciences, 2020 Cold-active enzymes increase their catalytic efficiency at low-temperature, introducing structural flexibility at or near the active sites. Inevitably, this feat seems to be accompanied by lower thermal stability.
Sondavid K. Nandanwar +3 more
doaj +1 more source
Effect of Substrate Thickness on Responsivity of Free-Membrane Bolometric Detectors [PDF]
arXiv, 2011 The effect of substrate thickness and its Debye temperature on the bolometric response of the freestanding-membrane type of superconductor transition-edge detectors is investigated. The investigation is based on the calculation of the variation of the specific heat per unit volume and the heat conductivity using the finite-size scaling method for ...
arxiv
Molecular Oncology, EarlyView.Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy +12 more
wiley +1 more source
Pacification of thermocapillary destabilization of a liquid film in zero gravity through the use of an isothermal porous substrate [PDF]
arXiv, 2017 Thin liquid films on isothermal substrates, where film is flat and parallel to the substrate, succumb to thermocapillary instabilities and rupture forming local hot-spots. These instabilities are called long wavelength instabilities and are specific to aspect ratios where the liquid film mean thickness is several orders of magnitude less than the ...
arxiv
Proofreading through spatial gradients [PDF]
arXiv, 2020 Key enzymatic processes in biology use the nonequilibrium error correction mechanism called kinetic proofreading to enhance their specificity. Kinetic proofreading typically requires several dedicated structural features in the enzyme, such as a nucleotide hydrolysis site and multiple enzyme-substrate conformations that delay product formation.
arxiv