Substrate specificity and structural investigation into PepO and PepW : two peptidases from Lactobacillus rhamnosus : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Biochemistry at Massey University, Palmerston North, New Zealand [PDF]
, 2005 The proteolytic systems of lactic acid bacteria have important roles in the maturation and flavour development of cheese. Lactic acid bacteria pepetidases contribute to the taste of cheese through the production of low-molecular weight peptides and free ...
Yates, Karen Maree
core
Sensitive and specific detection of explosives in solution and vapour by surface-enhanced Raman spectroscopy on silver nanocubes [PDF]
, 2017 Surface-enhanced Raman spectroscopy (SERS) has been widely utilised as a sensitive analytical technique for the detection of trace levels of organic molecules.
Ben-Jaber, Sultan +5 more
core +2 more sources
The structure and substrate specificity of human Cdk12/Cyclin K
Nature Communications, 2014 Phosphorylation of the RNA polymerase II C-terminal domain (CTD) by cyclin-dependent kinases is important for productive transcription. Here we determine the crystal structure of Cdk12/CycK and analyse its requirements for substrate recognition.
C. A. Bösken +9 more
semanticscholar +1 more source
TRAF2 binds to TIFA via a novel motif and contributes to its autophagic degradation
FEBS Letters, EarlyView.TRAF family members couple receptor signalling complexes to downstream outputs, but how they interact with these complexes is not always clear. Here, we show that during ADP‐heptose signalling, TRAF2 binding to TIFA requires two short sequence motifs in the C‐terminal tail of TIFA, which are distinct from the TRAF6 binding motif.
Tom Snelling +4 more
wiley +1 more source
Hsc66 substrate specificity is directed toward a discrete region of the iron-sulfur cluster template protein IscU [PDF]
, 2002 Hsc66 and Hsc20 comprise a specialized chaperone system important for the assembly of iron-sulfur clusters in Escherchia coli. Only a single substrate, the Fe/S template protein IscU, has been identified for the Hsc66/Hsc20 system, but the mechanism by ...
Hoff, Kevin G. +4 more
core +1 more source
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
Block-based characterization of protease specificity from substrate sequence profile
BMC Bioinformatics, 2017 Background The mechanism of action of proteases has been widely studied based on substrate specificity. Prior research has been focused on the amino acids at a single amino acid site, but rarely on combinations of amino acids around the cleavage bond ...
Enfeng Qi +4 more
doaj +1 more source
Structural basis for substrate specificity and catalysis of α1,6-fucosyltransferase
Nature Communications, 2020 Core-fucosylation of the N-glycan core is an essential biological modification and the α1,6- fucosyltransferase FUT8 is the only enzyme in humans that catalyses this modification through the addition of an α-1,6-linked fucose to N-glycans.
Ana García-García +6 more
doaj +1 more source
Communications Biology, 2023 Engineering of transporters to alter substrate specificity as desired holds great potential for applications, including metabolic engineering. However, the lack of knowledge on molecular mechanisms of substrate specificity hinders designing effective ...
Yuhan Jiang +8 more
doaj +1 more source
Substrate Specificity of Purified Recombinant Human β-Carotene 15,15′-Oxygenase (BCO1)*
Journal of Biological Chemistry, 2013 Background: The human enzyme β-carotene 15,15′-oxygenase (BCO1) produces vitamin A from carotenoids in food. Results: BCO1 catalyzes the oxidative cleavage of the 15–15′ double bond of major dietary provitamin A carotenoids, β-apocarotenals, and lycopene.
Carlo C. dela Seña +5 more
semanticscholar +1 more source