Results 101 to 110 of about 810,832 (336)

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Substrate and Donor Specificity of Glycosyl Transferases [PDF]

, 2018
It has been shown that all selectins recognize the carbohydrate epitopes sialyl Lewisx and sialyl Lewisa. For the establishment of the structure-activity relationship, the efficient synthesis of these tetrasaccharides and derivatives is therefore of ...
Ernst, Beat, Oehrlein, Reinhold
core  

Structural basis for DNMT3A-mediated de novo DNA methylation. [PDF]

, 2018
DNA methylation by de novo DNA methyltransferases 3A (DNMT3A) and 3B (DNMT3B) at cytosines is essential for genome regulation and development. Dysregulation of this process is implicated in various diseases, notably cancer.
Chen, Dongliang, Gao, Linfeng, Ji, Debin, Liu, Shuo, Lu, Rui, Rothbart, Scott B, Song, Jikui, Wang, Gang Greg, Wang, Pengcheng, Wang, Yinsheng, Yu, Yang, Zhang, Zhi-Min   +11 more
core   +2 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Substrate Specificity and Enzymatic Characteristics of Three Rutinosidases

Shipin gongye ke-ji
Quercetin, naringenin, and hesperetin are the hydrolysis products of rutinoside flavonoids, known for their multiple biological activities and potential applications.
Fengwei XIAO, Jiang SUN, Jiaying YE, Lijun LI, Hui NI   +4 more
doaj   +1 more source

Detection of myocardial scar from the VCG using a supervised learning approach [PDF]

, 2013
This paper addresses the possibility of detecting presence of scar tissue in the myocardium through the in- vestigation of vectorcardiogram (VCG) characteristics.
Dima, Sofia-Maria, Gialelis, John, Maharatna, Koushik, Mazomenos, Evangelos B., Morgan, John M., Panagiotou, Christos, Rosengarten, James   +6 more
core   +1 more source

Substrate Specificity of Soybean Lipoxidase

Journal of Biological Chemistry, 1969
Abstract Purified soybean lipoxidase was used to test the substrate specificity of all cis,cis-methylene-interrupted isomers of linoleic acid. The natural 9,12-isomer was found to be the best substrate, and the 13,16-isomer 50% as effective. The presence of calcium ions broadened the pattern of specificity.
R T, Holman, P O, Egwim, W W, Christie
openaire   +2 more sources

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Taking Advantage of Promiscuity of Cold-Active Enzymes

Applied Sciences, 2020
Cold-active enzymes increase their catalytic efficiency at low-temperature, introducing structural flexibility at or near the active sites. Inevitably, this feat seems to be accompanied by lower thermal stability.
Sondavid K. Nandanwar, Shweta Bharat Borkar, Jun Hyuck Lee, Hak Jun Kim   +3 more
doaj   +1 more source