Results 191 to 200 of about 792,149 (335)

Asparaginyl Ligases with Engineered Substrate Specificity for Controlled, Sequential Transpeptidation Reactions. [PDF]

J Am Chem Soc
Zhou Y, de Veer SJ, Tyler TJ, Chen Y, Durek T, Craik DJ, Rehm FBH.   +6 more
europepmc   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

Relaxed DNA substrate specificity of transposases involved in programmed genome rearrangement. [PDF]

Nucleic Acids Res
Walker MWG, Akematsu T, Aslan E, Villano DJ, Fried HS, Lan H, Sternberg SH, Landweber LF.   +7 more
europepmc   +1 more source

Substrate Specificity of Escherichia coli Peptidyl‐Transferase [PDF]

, 1970
Amos Panet, Nathan de Groot, Y. Lapidot
openalex   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Structure-Function Analysis of an Understudied Type of LPMO with Unique Redox Properties and Substrate Specificity. [PDF]

ACS Catal
Hall KR, Elisa Rønnekleiv S, Gautieri A, Lilleås H, Skaali R, Rieder L, Nikoline Englund A, Landsem E, Emrich-Mills TZ, Ayuso-Fernández I, Kjendseth Røhr Å, Sørlie M, Eijsink VGH.   +12 more
europepmc   +1 more source

Butyramide-utilizing Mutants of Pseudomonas aeruginosa 8602 which Produce an Amidase with Altered Substrate Specificity

, 1969
Jackie Brown, Paul R. Brown, Patricia H. Clarke   +2 more
openalex   +1 more source

Substrate Specificity via Ternary Complex Formation with Glutamate Dehydrogenase [PDF]

, 1977
Henk KOEKOEK, George T. Robillard
openalex   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source