Results 191 to 200 of about 810,832 (336)

On the Origin of Substrate Specificity of Enzymes from the Amidohydrolase Superfamily. [PDF]

Angew Chem Int Ed Engl
Drexler L, F Fürtges T, Rudack T, Sterner R.   +3 more
europepmc   +1 more source

The Akt1-eNOS Axis Illustrates the Specificity of Kinase-Substrate Relationships in Vivo

, 2009
Michael Schleicher, Jun Yu, Takahisa Murata, Berhad Derakhshan, Dmitriy N. Atochin, Qian Li, Satoshi Kashiwagi, Annarita Di Lorenzo, Kenneth Harrison, Paul L. Huang, William C. Sessa   +10 more
openalex   +2 more sources

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Ub-POD: A Ubiquitin-Specific Proximity-Dependent Labeling Technique to Identify E3 Ubiquitin Ligase Substrates in Human Cells

Urbi Mukhopadhyay, Sophie Levantovsky, Christian Behrends, Sagar Bhogaraju   +3 more
openalex   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

A method for predicting enzyme substrate specificity residues using homologous sequence information. [PDF]

Protein Sci
Mori S, Niide T, Toya Y, Shimizu H.
europepmc   +1 more source

Conversion of glutamic acid 192 to glutamine in activated protein C changes the substrate specificity and increases reactivity toward macromolecular inhibitors.

, 1993
Alireza R. Rezaie, Charles T. Esmon
openalex   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Arsenic regulates ALKBH1 abundance and substrate specificity to promote translation and tumorigenicity. [PDF]

Cell Rep
Wilkinson E, Cui YH, Yang Z, Verghese M, Yang S, Sun M, Zhu H, Peterson J, Wei J, Zhao Y, Chen M, He C, He YY.   +12 more
europepmc   +1 more source

THE SUBSTRATE SPECIFICITY AND INHIBITION CHARACTERISTICS OF TWO COPPER-PROTEIN “OXIDASES”

, 1939
James F. McCarthy, Lowell F. Green, C. G. King   +2 more
openalex   +1 more source