Results 201 to 210 of about 810,832 (336)

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Conformational plasticity across phylogenetic clusters of RND multidrug efflux pumps and its impact on substrate specificity. [PDF]

Nat Commun
Lazarova M, Eicher T, Börnsen C, Zeng H, Athar M, Okada U, Yamashita E, Spannaus IM, Borgosch M, Cha HJ, Vargiu AV, Murakami S, Diederichs K, Frangakis AS, Pos KM.   +14 more
europepmc   +1 more source

Melanoma antigen-A11 regulates substrate-specificity of Skp2-mediated protein degradation

, 2016
Shifeng Su, Xiaoyu Chen, Jiang Geng, John T. Minges, Gail Grossman, Elizabeth M. Wilson   +5 more
openalex   +1 more source

Self-cleaving ribozymes: substrate specificity and synthetic biology applications

, 2021
Huan Peng, Brandon Latifi, Sabine Müller, Andrej Lupták, Irene A. Chen   +4 more
openalex   +2 more sources

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

Mrx6 binds the Lon protease Pim1 N-terminal domain to confer selective substrate specificity and regulate mtDNA copy number. [PDF]

Nucleic Acids Res
Schrott S, Marafelli I, Gerle C, Bibinger S, Bertgen L, Marino G, Schwenkert S, Rathberger R, Herrmann JM, Osman C.   +9 more
europepmc   +1 more source

Negative selectivity and the evolution of protease cascades: the specificity of plasmin for peptide and protein substrates [PDF]

, 2000
Laurence Hervio, Gary S. Coombs, Robert C. Bergstrom, Kavita K. Trivedi, David R. Corey, Edwin L. Madison   +5 more
openalex   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

ALKALINE PH DEPENDENCE OF δCHYMOTRYPSIN-CATALYZED HYDROLYSIS OF SPECIFIC SUBSTRATES

, 1969
Pablo Valenzuela, Myron L. Bender
openalex   +2 more sources

Further studies on the substrate specificity and inhibition of the stereospecific CS2 secondary alkylsulphohydrolase of Comamonas terrigena [PDF]

, 1980
Carol H. Barrett, Kenneth S. Dodgson, Graham F. White   +2 more
openalex   +1 more source