Results 221 to 230 of about 810,832 (336)

Structure-Function Analysis of an Understudied Type of LPMO with Unique Redox Properties and Substrate Specificity. [PDF]

ACS Catal
Hall KR, Elisa Rønnekleiv S, Gautieri A, Lilleås H, Skaali R, Rieder L, Nikoline Englund A, Landsem E, Emrich-Mills TZ, Ayuso-Fernández I, Kjendseth Røhr Å, Sørlie M, Eijsink VGH.   +12 more
europepmc   +1 more source

Patatin‐domain‐containing (phospho)lipases under control: Mammalian co‐regulators and pathogenic activation mechanisms

FEBS Open Bio, EarlyView.
Patatin domain‐containing (phospho)lipases are lipid‐hydrolyzing enzymes central to metabolism, membrane remodeling, and signaling. Their activity relies on precise co‐activation mechanisms involving protein–protein interactions and conformational rearrangements.
Noopur Dubey, Lina Riegler‐Berket, Monika Oberer   +2 more
wiley   +1 more source

Structural and functional insights into the substrate specificity of the pseudouridine monophosphate phosphatase HDHD1A. [PDF]

J Biol Chem
Seo S, Kim M, Rhee S.
europepmc   +1 more source

Phospho-Form Specific Substrates of Protein Kinase B (AKT1)

, 2021
McShane McKenna, Nileeka Balasuriya, Shanshan Zhong, Shawn S.‐C. Li, Patrick O’Donoghue   +4 more
openalex   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Deciphering the unique autoregulatory mechanisms and substrate specificity of the understudied DCLK3 kinase linked to neurodegenerative diseases. [PDF]

J Biol Chem
Lu JD, Zhao P, Prasad A, Gupta N, Gravel N, Shidhaye T, Wells L, Katiyar S, Kannan N.   +8 more
europepmc   +1 more source

The Dependence of the Substrate Specificity on the Conformation of Crystalline Glutamate Dehydrogenase

, 1965
Gordon M. Tomkins, K. Lemone Yielding, Jean F. Curran, Murray R. Summers, Mark W. Bitensky   +4 more
openalex   +1 more source

New intramolecularly quenched fluorogenic peptide substrates for the study of the kinetic specificity of papain [PDF]

, 1992
Carlos Garcia-Echeverria, Daniel H. Rich
openalex   +1 more source

Substrate specificity of human chymotrypsin-like protease (CTRL) characterized by phage display-selected small-protein inhibitors

, 2023
Bálint Zoltán Németh, Zoltán Attila Nagy, Bence Kiss, Gabriella Gellén, Gitta Schlosser, Alexandra Demcsák, Andrea Geisz, Eszter Hegyi, Miklós Sahin‐Tóth, Gábor Pál   +9 more
openalex   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source