Results 241 to 250 of about 10,438,012 (377)

The Substrate Specificity of Riboflavin Synthetase

Journal of Biological Chemistry, 1963
Claire Hummel Winestock, G.W.E. Plaut, T. Aogaichi   +2 more
openaire   +3 more sources

LIN28B Promotes Cancer Cell Dissemination and Angiogenesis

Advanced Biology, EarlyView.
Children diagnosed with high‐risk neuroblastoma have a 5‐year event‐free survival rate of less than 50% and poor outcomes after recurrence. Deregulation of the LIN28B oncogene can be addressed in these patients. Upregulation of LIN28B is shown to support the metastatic cascade.
Diana Corallo, Sara Menegazzo, Marcella Pantile, Silvia Bresolin, Carlo Zanon, Alessandro Davini, Massimiliano Mazzone, Alessandra Biffi, Sanja Aveic   +8 more
wiley   +1 more source

Biosynthesis of novel cannabigerolic acid derivatives by engineering the substrate specificity of aromatic prenyltransferase. [PDF]

Front Bioeng Biotechnol
Lee HS, Park J, Kim T, Min H, Na S, Park SY, Park YT, Yeon YJ, Ham J.   +8 more
europepmc   +1 more source

Inhibition of Glutamine Metabolism Attenuates Tumor Progression Through Remodeling of the Macrophage Immune Microenvironment

Advanced Biology, EarlyView.
The prodrug strategy used in this study offers new promise for cancer metabolism‐based therapies. JHU083, a prodrug that, when cleaved by protease in the tumor microenvironment, yields the glutamine antagonist DON. JHU083 inhibits tumor growth by targeting glutamine‐addicted cancer cells and suppressing glutamine‐dependent M2 macrophages, leading to a ...
Tianhe Li, Sepehr Akhtarkhavari, Sumeng Qi, Jiawei Fan, Tu‐Yung Chang, Yao‐An Shen, JinMing Yang, Barbara S. Slusher, Ie‐Ming Shih, Stephanie Gaillard, Tian‐Li Wang   +10 more
wiley   +1 more source

Investigation on the Substrate Specificity of Serine Protease Neuropsin by Molecular Dynamics Simulation and Marmoset Gene Atlas (MGA). [PDF]

ACS Omega
Lintuluoto M, Horioka Y, Fujiwara M, Abe M, Fukunishi Y, Tamura H, Lintuluoto JM.   +6 more
europepmc   +1 more source

HMGB1 Derived from the Pyroptotic Microenvironment Promotes Macrophage Extracellular Traps in Hirschsprung‐Associated Enterocolitis

Advanced Biology, EarlyView.
HMGB1 derived from the pyroptotic environment in Hirschsprung‐associated enterocolitis mediates the formation of macrophage extracellular traps through TLR4 ‐p38 MAPK/p65 NF‐kB signaling pathways. Macrophage extracellular traps induce increased ROS production and pyroptosis of colonic epithelial cells.
Rui Zhang, Jing Li, Lili Song, Liya Pan, Chengchen Zhang, Zhiyan Zhan, Li Hong   +6 more
wiley   +1 more source

The Substrate Specificity of Phenylamine-β-hydroxylase

, 1962
M. Goldstein, Joseph F. Contrera
openalex   +1 more source

Redesigning and characterizing the substrate specificity and activity of Vibrio fluvialis aminotransferase for the synthesis of imagabalin.

Protein engineering, design & selection : PEDS, 2013
K. Midelfort, Rajesh Kumar, Seungil Han, M. Karmilowicz, K. McConnell, D. Gehlhaar, A. Mistry, Jeanne S. Chang, Marie Anderson, A. Villalobos, J. Minshull, S. Govindarajan, J. W. Wong   +12 more
semanticscholar   +1 more source

Optimized Cell‐Based Platform for Platelet‐Free Detection of Heparin‐Induced Thrombocytopenia Antibodies

Advanced Biology, EarlyView.
This study optimized a cell‐based ELISA for HIT antibody detection using PF4‐coated breast cancer cells (MDA‐MB‐231). Enhanced binding was observed at 50 mM NaCl and 4% paraformaldehyde fixation. Live MDA‐MB‐231 and HCT‐116 cells demontrated superior sensitivity and specificity, providing a promising platelet‐free alternative for clinical HIT diagnosis.
Li‐Yu Chen, Uwe Schirmer, Peter F. Zipfel, Doris Heinrich, Thi‐Huong Nguyen   +4 more
wiley   +1 more source

Structural Insights into Isovaleryl-Coenzyme A Dehydrogenase: Mechanisms of Substrate Specificity and Implications of Isovaleric Acidemia-Associated Mutations. [PDF]

Research (Wash D C)
Ju K, Bai F, Xu Y, Li Q, Su G, Jin Y, Chen H, Zhang S, Luan X.   +8 more
europepmc   +1 more source