Results 31 to 40 of about 2,216,866 (310)
Elucidation of substrate specificity in Aspergillus nidulans UDP-galactose-4-epimerase. [PDF]
PLoS ONE, 2013 The frequency of invasive fungal infections has rapidly increased in recent years. Current clinical treatments are experiencing decreased potency due to severe host toxicity and the emergence of fungal drug resistance.
Sean A Dalrymple +4 more
doaj +1 more source
The loops facing the active site of prolyl oligopeptidase are crucial components in substrate gating and specificity [PDF]
, 2013 Prolyl oligopeptidase (POP) has emerged as a drug target for neurological diseases. A flexible loop structure comprising loop A (res. 189–209) and loop B (res. 577–608) at the domain interface is implicated in substrate entry to the active site.
Juliano, Luiz +10 more
core +1 more source
Substrate specificity of the cypemycin decarboxylase CypD
Synthetic and Systems Biotechnology, 2018 The linaridin antibiotic cypemycin is a ribosomal synthesized and post-translationally modified peptide (RiPP) that possesses potent activity against mouse leukemia cells.
Wei Ding +3 more
doaj +1 more source
Journal of Lipid Research, 1993 In this study we used monoacid triacylglycerols of various acyl-chain lengths as substrates for probing the active-site structure and substrate specificity of lipoprotein lipase (LPL).
Chi-Sun Wang +3 more
doaj +1 more source
Phosphotyrosine Substrate Sequence Motifs for Dual Specificity Phosphatases. [PDF]
PLoS ONE, 2015 Protein tyrosine phosphatases dephosphorylate tyrosine residues of proteins, whereas, dual specificity phosphatases (DUSPs) are a subgroup of protein tyrosine phosphatases that dephosphorylate not only Tyr(P) residue, but also the Ser(P) and Thr(P ...
Bryan M Zhao +8 more
doaj +1 more source
Green Chemical Engineering, 2021 Substrate specificity is a hallmark of enzymatic catalysis. In this work, the biomimetic catalytic oxidation of styrene and cyclohexanone by iron (III) porphyrins and molecular oxygen was carried out, and remarkable differences in efficiency were ...
Xian-Tai Zhou, Hong-Bing Ji
doaj +1 more source
Substrate specificity of the TRAMP nuclear surveillance complexes
Nature Communications, 2020 During nuclear surveillance in yeast and human cells, the RNA exosome functions together with the TRAMP complexes. Here, the authors defined the protein composition of the TRAMP complexes and identified specific RNA binding sites for the different TRAMP ...
Clémentine Delan-Forino +3 more
doaj +1 more source
Substrate promiscuity of the NdmCDE
Biotechnology NotesMethylxanthines, including caffeine and theophylline, are a class of natural and synthetic compounds with important roles in food, cosmetics, and medicine.
Meredith B. Mock +5 more
doaj +1 more source
Biomolecules, 2022 Jumonji C (JmjC) lysine demethylases (KDMs) catalyze the removal of methyl (-CH3) groups from modified lysyl residues. Several JmjC KDMs promote cancerous properties and these findings have primarily been in relation to histone demethylation.
Anand Chopra +2 more
doaj +1 more source
Broad substrate specificity of LuCGT1.
, 2020 Broad substrate specificity of LuCGT1.
Daoquan Xiang (501456) +7 more
core +1 more source