Results 11 to 20 of about 467,506 (265)
Structure-based engineering of substrate specificity for pinoresinol-lariciresinol reductases
Nature Communications, 2021 Pinoresinol–lariciresinol reductases (PLRs) are enzymes involved in the lignan biosynthesis. Here, crystal structures of three PLRs in the apo, substrate-bound and product-bound states, and accompanying mutagenesis provide insight into PLRs catalytic ...
Ying Xiao +13 more
doaj +1 more source
Substrate Specificity of Biofilms Proximate to Historic Shipwrecks
Microorganisms, 2023 The number of built structures on the seabed, such as shipwrecks, energy platforms, and pipelines, is increasing in coastal and offshore regions. These structures, typically composed of steel or wood, are substrates for microbial attachment and biofilm ...
Rachel L. Mugge +2 more
doaj +1 more source
The Substrate Specificity of Fumarase
Journal of Biological Chemistry, 1968 Abstract The substrate specificity of fumarase has been studied by measuring the ability of the enzyme to hydrate or dehydrate derivatives of fumarate and l-malate. Fumarase was observed to hydrate fumarate and its derivatives in the order, fluorofumarate g fumarate g chlorofumarate g bromofumarate g acetylenedicarboxylate g iodofumarate g mesaconate ...
J W, Teipel, G M, Hass, R L, Hill
openaire +2 more sources
Do Amino Acid Antiporters Have Asymmetric Substrate Specificity?
Biomolecules, 2023 Amino acid antiporters mediate the 1:1 exchange of groups of amino acids. Whether substrate specificity can be different for the inward and outward facing conformation has not been investigated systematically, although examples of asymmetric transport ...
Gregory Gauthier-Coles +3 more
doaj +1 more source
Substrate specificity of human ceramide kinase
Journal of Lipid Research, 2005 Previous studies in our laboratory have established ceramide kinase (CERK) as a critical mediator of eicosanoid synthesis. To date, CERK has not been well characterized in vitro.
Dayanjan S. Wijesinghe +5 more
doaj +1 more source
Dissecting the Cytochrome P450 OleP Substrate Specificity: Evidence for a Preferential Substrate
Biomolecules, 2020 The cytochrome P450 OleP catalyzes the epoxidation of aliphatic carbons on both the aglycone 8.8a-deoxyoleandolide (DEO) and the monoglycosylated L-olivosyl-8.8a-deoxyoleandolide (L-O-DEO) intermediates of oleandomycin biosynthesis.
Giacomo Parisi +10 more
doaj +1 more source
Comparative Studies on Retroviral Proteases: Substrate Specificity
Viruses, 2010 Exogenous retroviruses are subclassified into seven genera and include viruses that cause diseases in humans. The viral Gag and Gag-Pro-Pol polyproteins are processed by the retroviral protease in the last stage of replication and inhibitors of the HIV-1
József Tözsér
doaj +1 more source
Substrate specificity of human MCPIP1 endoribonuclease
Scientific Reports, 2018 MCPIP1, also known as Regnase-1, is a ribonuclease crucial for regulation of stability of transcripts related to inflammatory processes. Here, we report that MCPIP1 acts as an endonuclease by degrading several stem-loop RNA structures and single-stranded
Mateusz Wilamowski +3 more
doaj +1 more source
Substrate Specificity of Recombinant Ser/Thr Protein Kinase
Bio-Protocol, 2015 Protein kinases are enzymes that phosphorylate proteins in a cell. Determination of kinase activity in reactions of phosphorylation is a very convenient way for a biochemical characterization of this group of enzymes.
Anna Zorina, Galina Novikova, Dmitry Los
doaj +1 more source
Crystal Structure and Substrate Specificity of PTPN12
Cell Reports, 2016 PTPN12 is an important tumor suppressor that plays critical roles in various physiological processes. However, the molecular basis underlying the substrate specificity of PTPN12 remains uncertain.
Hui Li +18 more
doaj +1 more source