Results 11 to 20 of about 1,936,726 (258)
Substrate specificity of haloalkane dehalogenases [PDF]
Biochemical Journal, 2011 An enzyme's substrate specificity is one of its most important characteristics. The quantitative comparison of broad-specificity enzymes requires the selection of a homogenous set of substrates for experimental testing, determination of substrate-specificity data and analysis using multivariate statistics.
Tana, Koudelakova +6 more
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The Substrate Specificity of Pantethinase [PDF]
European Journal of Biochemistry, 1973 The substrate specificty of pantethinase, the mammalian enzyme which has been isolated from horse kidney cortex, has been studied. The real substrate has been found to be pantetheine in the reduced form, and the involvement of one or more—SH groups of the enzyme is also considered.A number of other compounds, chemically related to pantetheine, has also
S, Duprè +4 more
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Modulating Enzyme’s Activity and Specificity through Pre-Installed Posttranslational Modifications (PTMs) on Substrate: The Role of PTM-induced Substrate-Assisted Stimulation [PDF]
, 2023 Understanding the underlying principles for crosstalk involving posttranslational modifications (PTMs) is of fundamental importance. In this article, we review some of previous results which indicated that pre-installed PTMs on nucleosome substrates (or ...
Hong, Guo, Ping, Qian
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Substrate Specificity of the SecB Chaperone [PDF]
Journal of Biological Chemistry, 1999 The bacterial chaperone SecB assists translocation of proteins across the inner membrane. The mechanism by which it differentiates between secretory and cytosolic proteins is poorly understood. To identify its binding motif, we screened 2688 peptides covering sequences of 23 proteins for SecB binding.
Knoblauch, Nicola T. M. +5 more
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Evolution of substrate specificity in a recipient's enzyme following horizontal gene transfer [PDF]
, 2013 Despite the prominent role of horizontal gene transfer (HGT) in shaping bacterial metabolism, little is known about the impact of HGT on the evolution of enzyme function.
Noda-Garcia, Lianet +6 more
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The Substrate Specificity of Fumarase
Journal of Biological Chemistry, 1968 Abstract The substrate specificity of fumarase has been studied by measuring the ability of the enzyme to hydrate or dehydrate derivatives of fumarate and l-malate. Fumarase was observed to hydrate fumarate and its derivatives in the order, fluorofumarate g fumarate g chlorofumarate g bromofumarate g acetylenedicarboxylate g iodofumarate g mesaconate ...
J W, Teipel, G M, Hass, R L, Hill
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Computational Protein Design Force Field Optimization: A Negative Design Approach [PDF]
, 2007 An accurate force field is essential to computational protein design and protein folding studies. Proper force field tuning is problematic, however, due in part to the incomplete modeling of the unfolded state.
Alvizo, Oscar
core +1 more source
Determinants of Substrate Specificity in APOBEC3B [PDF]
, 2018 APOBEC3B (A3B) is a newly discovered driver of mutation in many cancers. We use computational tools to revert a recent crystal structure of an A3B construct to its native sequence, and run molecular dynamics simulations to study its underlying dynamics ...
Daniel A., Harki +6 more
core +1 more source
The loops facing the active site of prolyl oligopeptidase are crucial components in substrate gating and specificity [PDF]
, 2013 Prolyl oligopeptidase (POP) has emerged as a drug target for neurological diseases. A flexible loop structure comprising loop A (res. 189–209) and loop B (res. 577–608) at the domain interface is implicated in substrate entry to the active site.
Juliano, Luiz +10 more
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The evolution of cyclodextrin glucanotransferase product specificity [PDF]
, 2009 Cyclodextrin glucanotransferases (CGTases) have attracted major interest from industry due to their unique capacity of forming large quantities of cyclic α-(1,4)-linked oligosaccharides (cyclodextrins) from starch.
Dijkhuizen, Lubbert; id_orcid +9 more
core +3 more sources