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Comparative Studies on Retroviral Proteases: Substrate Specificity
Viruses, 2010 Exogenous retroviruses are subclassified into seven genera and include viruses that cause diseases in humans. The viral Gag and Gag-Pro-Pol polyproteins are processed by the retroviral protease in the last stage of replication and inhibitors of the HIV-1
József Tözsér
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Causal analysis of A domain substrate specificity.
, 2023 The specificity-conferring code distance used is alignment-score distance. A domain sequence distance used is p-distance. The loop length distance used is Euclidean distance. r is Pearson correlation coefficient. A.
Chen Song (216175) +7 more
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Modulating Enzyme’s Activity and Specificity through Pre-Installed Posttranslational Modifications (PTMs) on Substrate: The Role of PTM-induced Substrate-Assisted Stimulation [PDF]
, 2023 Understanding the underlying principles for crosstalk involving posttranslational modifications (PTMs) is of fundamental importance. In this article, we review some of previous results which indicated that pre-installed PTMs on nucleosome substrates (or ...
Hong, Guo +3 more
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Substrate specificity of human MCPIP1 endoribonuclease
Scientific Reports, 2018 MCPIP1, also known as Regnase-1, is a ribonuclease crucial for regulation of stability of transcripts related to inflammatory processes. Here, we report that MCPIP1 acts as an endonuclease by degrading several stem-loop RNA structures and single-stranded
Mateusz Wilamowski +3 more
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Substrate Specificity of Recombinant Ser/Thr Protein Kinase
Bio-Protocol, 2015 Protein kinases are enzymes that phosphorylate proteins in a cell. Determination of kinase activity in reactions of phosphorylation is a very convenient way for a biochemical characterization of this group of enzymes.
Anna Zorina, Galina Novikova, Dmitry Los
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Crystal Structure and Substrate Specificity of PTPN12
Cell Reports, 2016 PTPN12 is an important tumor suppressor that plays critical roles in various physiological processes. However, the molecular basis underlying the substrate specificity of PTPN12 remains uncertain.
Hui Li +18 more
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The substrate specificity of phospholipase A
Biochimica et Biophysica Acta (BBA) - Specialized Section on Lipids and Related Subjects, 1963 Investigations on variously modified analogues of phospholipids elucidated the following substrate characteristics for phospholipase A (Crotalus adamanteus). 1. 1. Within the class of α-phosphoglycerides l-isomers are readily hydrolysed, while d-α-phospholipids appeared not to be attacked. 2. 2.
Deenen, L.L.M. van, Haas, Gerard H. de
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On the substrate specificity of human CYP27A1
Journal of Lipid Research, 2003 The mitochondrial sterol 27-hydroxylase (CYP27A1) is required for degradation of the C27-sterol side chain in bile acid biosynthesis. CYP27A1 seems, however, to have roles beyond this, as illustrated by patients with a deficient sterol 27-hydroxylase due
Maria Norlin +3 more
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Substrate Specificity of Chlorophyllase [PDF]
Plant Physiology, 1975 Apparent Km and V(max) values were obtained for hydrolysis of methyl and ethyl chlorophyllides a, methyl and ethyl pheophorbide a, and 9-hydroxymethyl pheophorbide a by chlorophyllase from Ailanthus altissima. Analysis of substrate specificity data for chlorophyllase indicates that the presence of a 9-keto group and a methyl alcohol group esterified at
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Determinants of MDR1 P-glycoprotein substrate specificity.
, 1995 Determinants of MDR1 P-glycoprotein substrate ...
David. de Graaf (7996691)
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