Results 41 to 50 of about 2,216,866 (310)

Substrate-specific signature sequences (SSSS) or specificity determining positions (SDPs) in MIPs transporting non-aqua substrates.

, 2016
Substrate-specific signature sequences (SSSS) or specificity determining positions (SDPs) in MIPs transporting non-aqua substrates.
Takahiro Ishikawa (639481), Abul Kalam Azad (3165174), Md. Mahbub Hasan (3165168), Maki Katsuhara (3165165), Jahed Ahmed (3165171), Md. Asraful Alum (3165177), Yoshihiro Sawa (3165162)   +6 more
core   +1 more source

Probabilistic approach to predicting substrate specificity of methyltransferases.

PLoS Computational Biology, 2014
We present a general probabilistic framework for predicting the substrate specificity of enzymes. We designed this approach to be easily applicable to different organisms and enzymes.
Teresa Szczepińska, Jan Kutner, Michał Kopczyński, Krzysztof Pawłowski, Andrzej Dziembowski, Andrzej Kudlicki, Krzysztof Ginalski, Maga Rowicka   +7 more
doaj   +1 more source

Substrate specificity of LaclK.

, 2016
Substrate specificity of LaclK.
Zhiyong Ruan (470472), Huimin Wang (130504), Mingxiong He (653738), Weiwei Dong (462016), Guoquan Hu (3220956), Yanwei Wang (404550), Jinlong Song (470474), Delong Kong (1581034), Shan Zhou (112166), Jie Zhu (126574), Xiang Guo (223678)   +10 more
core   +1 more source

Substrate specificity of Ty1 integrase [PDF]

Journal of Virology, 1995
Integration of the Saccharomyces cerevisiae retrotransposon Ty1 requires the element-encoded integrase (IN) protein, which is a component of cytoplasmic virus-like particles (VLPs). Using purified recombinant Ty1 IN and an oligonucleotide integration assay based on Ty1 long terminal repeat sequences, we have compared IN activity on substrates having ...
S P, Moore, M, Powers, D J, Garfinkel
openaire   +2 more sources

The impact of tunnel mutations on enzymatic catalysis depends on the tunnel-substrate complementarity and the rate-limiting step

Computational and Structural Biotechnology Journal, 2020
Transport of ligands between bulk solvent and the buried active sites is a critical event in the catalytic cycle of many enzymes. The rational design of transport pathways is far from trivial due to the lack of knowledge about the effect of mutations on ...
Piia Kokkonen, Michaela Slanska, Veronika Dockalova, Gaspar P. Pinto, Esther M. Sánchez-Carnerero, Jiri Damborsky, Petr Klán, Zbynek Prokop, David Bednar   +8 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Substrate specificity of LacA.

, 2014
Substrate specificity of LacA.
Qi Lin (511383), Tzi Bun Ng (287770), Juan Lin (171491), Xiuyun Ye (651745), Jie Yang (121778)   +4 more
core   +1 more source

Structural basis for substrate specificity of mammalian neuraminidases.

PLoS ONE, 2014
The removal of sialic acid (Sia) residues from glycoconjugates in vertebrates is mediated by a family of neuraminidases (sialidases) consisting of Neu1, Neu2, Neu3 and Neu4 enzymes.
Victoria Smutova, Amgad Albohy, Xuefang Pan, Elena Korchagina, Taeko Miyagi, Nicolai Bovin, Christopher W Cairo, Alexey V Pshezhetsky   +7 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Substrate specificity of the enzymes.

, 2018
Substrate specificity of the enzymes.
Masayuki Nakamura (2537542), Takashi Honda (775852), Yuta Okamura (5617331), Hisashi Iwai (5617337), Akira Furusawa (4353106), Tamao Fuchiwaki (5617328), Kiyotaka Fujita (5617334), Yuino Yasukawa (5617325)   +7 more
core   +1 more source