Results 41 to 50 of about 797,048 (304)
The Substrate Specificity of Pantethinase [PDF]
European Journal of Biochemistry, 1973 The substrate specificty of pantethinase, the mammalian enzyme which has been isolated from horse kidney cortex, has been studied. The real substrate has been found to be pantetheine in the reduced form, and the involvement of one or more—SH groups of the enzyme is also considered.A number of other compounds, chemically related to pantetheine, has also
S, Duprè +4 more
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Mechanisms Regulating the Association of Protein Phosphatase 1 with Spinophilin and Neurabin [PDF]
, 2018 Protein phosphorylation is a key mediator of signal transduction, allowing for dynamic regulation of substrate activity. Whereas protein kinases obtain substrate specificity by targeting specific amino acid sequences, serine/threonine phosphatase ...
Baucum, Anthony J., II +6 more
core +1 more source
Substrate Specificity of Peptide Adsorption: A Model Study
, 2007 Applying the contact density chain-growth algorithm to lattice heteropolymers, we identify the conformational transitions of a nongrafted hydrophobic-polar heteropolymer with 103 residues in the vicinity of a polar, a hydrophobic, and a uniformly ...
L. Toma +2 more
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Directed enzyme evolution: climbing fitness peaks one amino acid at a time [PDF]
, 2009 Directed evolution can generate a remarkable range of new enzyme properties. Alternate substrate specificities and reaction selectivities are readily accessible in enzymes from families that are naturally functionally diverse.
Arnold, Frances H., Tracewell, Cara A.
core +2 more sources
Inflammatory caspase substrate specificities
mBioABSTRACT Caspases are a family of cysteine proteases that act as molecular scissors to cleave substrates and regulate biological processes such as programmed cell death and inflammation. Extensive efforts have been made to identify caspase substrates and to determine factors that dictate substrate specificity ...
Patrick M. Exconde +4 more
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Probabilistic approach to predicting substrate specificity of methyltransferases.
PLoS Computational Biology, 2014 We present a general probabilistic framework for predicting the substrate specificity of enzymes. We designed this approach to be easily applicable to different organisms and enzymes.
Teresa Szczepińska +7 more
doaj +1 more source
Computational and Structural Biotechnology Journal, 2020 Transport of ligands between bulk solvent and the buried active sites is a critical event in the catalytic cycle of many enzymes. The rational design of transport pathways is far from trivial due to the lack of knowledge about the effect of mutations on ...
Piia Kokkonen +8 more
doaj +1 more source
The cell surface receptor Tartan is a potential in vivo substrate for the receptor tyrosine phosphatase Ptp52F [PDF]
, 2009 Receptor-linked protein-tyrosine phosphatases (RPTPs) are essential regulators of axon guidance and synaptogenesis in Drosophila, but the signaling pathways in which they function are poorly defined.
Bugga, Lakshmi +2 more
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A P-type ATPase importer that discriminates between essential and toxic transition metals [PDF]
, 2009 Transition metals, although being essential cofactors in many physiological processes, are toxic at elevated concentrations. Among the membrane-embedded transport proteins that maintain appropriate intracellular levels of transition metals are ATP-driven
A. T. Lee +25 more
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Crystal structure and substrate specificity of Drosophila 3,4-dihydroxyphenylalanine decarboxylase. [PDF]
PLoS ONE, 2010 3,4-Dihydroxyphenylalanine decarboxylase (DDC), also known as aromatic L-amino acid decarboxylase, catalyzes the decarboxylation of a number of aromatic L-amino acids.
Qian Han +4 more
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