Results 41 to 50 of about 494,088 (314)

Substrate specificity of the AKR.

, 2021
Substrate specificity of the AKR.
Xiaoli Fu (316464), Weiliang Wu (844558), Wei Jiang (14986)   +2 more
core   +1 more source

Substrate specificity of the TRAMP nuclear surveillance complexes

Nature Communications, 2020
During nuclear surveillance in yeast and human cells, the RNA exosome functions together with the TRAMP complexes. Here, the authors defined the protein composition of the TRAMP complexes and identified specific RNA binding sites for the different TRAMP ...
Clémentine Delan-Forino, Christos Spanos, Juri Rappsilber, David Tollervey   +3 more
doaj   +1 more source

Probabilistic approach to predicting substrate specificity of methyltransferases.

PLoS Computational Biology, 2014
We present a general probabilistic framework for predicting the substrate specificity of enzymes. We designed this approach to be easily applicable to different organisms and enzymes.
Teresa Szczepińska, Jan Kutner, Michał Kopczyński, Krzysztof Pawłowski, Andrzej Dziembowski, Andrzej Kudlicki, Krzysztof Ginalski, Maga Rowicka   +7 more
doaj   +1 more source

On the substrate specificity of glucose oxidase

Biochimica et Biophysica Acta, 1957
Peer ...
Sols, Alberto, Fuente Sánchez, Gertrudis de la   +1 more
openaire   +3 more sources

Determinants of Substrate Specificity in APOBEC3B

, 2018
APOBEC3B (A3B) is a newly discovered driver of mutation in many cancers. We use computational tools to revert a recent crystal structure of an A3B construct to its native sequence, and run molecular dynamics simulations to study its underlying dynamics ...
Daniel A., Harki, Özlem, Demir, Jeffrey, Wagner, Michael A., Carpenter, Reuben S., Harris, Rommie E., Amaro, Hideki, Aihara   +6 more
core   +1 more source

The impact of tunnel mutations on enzymatic catalysis depends on the tunnel-substrate complementarity and the rate-limiting step

Computational and Structural Biotechnology Journal, 2020
Transport of ligands between bulk solvent and the buried active sites is a critical event in the catalytic cycle of many enzymes. The rational design of transport pathways is far from trivial due to the lack of knowledge about the effect of mutations on ...
Piia Kokkonen, Michaela Slanska, Veronika Dockalova, Gaspar P. Pinto, Esther M. Sánchez-Carnerero, Jiri Damborsky, Petr Klán, Zbynek Prokop, David Bednar   +8 more
doaj   +1 more source

Substrate specificity of Ty1 integrase [PDF]

Journal of Virology, 1995
Integration of the Saccharomyces cerevisiae retrotransposon Ty1 requires the element-encoded integrase (IN) protein, which is a component of cytoplasmic virus-like particles (VLPs). Using purified recombinant Ty1 IN and an oligonucleotide integration assay based on Ty1 long terminal repeat sequences, we have compared IN activity on substrates having ...
S P, Moore, M, Powers, D J, Garfinkel
openaire   +2 more sources

Structural basis for substrate specificity of mammalian neuraminidases.

PLoS ONE, 2014
The removal of sialic acid (Sia) residues from glycoconjugates in vertebrates is mediated by a family of neuraminidases (sialidases) consisting of Neu1, Neu2, Neu3 and Neu4 enzymes.
Victoria Smutova, Amgad Albohy, Xuefang Pan, Elena Korchagina, Taeko Miyagi, Nicolai Bovin, Christopher W Cairo, Alexey V Pshezhetsky   +7 more
doaj   +1 more source

Crystal structure and substrate specificity of Drosophila 3,4-dihydroxyphenylalanine decarboxylase. [PDF]

PLoS ONE, 2010
3,4-Dihydroxyphenylalanine decarboxylase (DDC), also known as aromatic L-amino acid decarboxylase, catalyzes the decarboxylation of a number of aromatic L-amino acids.
Qian Han, Haizhen Ding, Howard Robinson, Bruce M Christensen, Jianyong Li   +4 more
doaj   +1 more source

Substrate-specific signature sequences (SSSS) or specificity determining positions (SDPs) in MIPs transporting non-aqua substrates.

, 2016
Substrate-specific signature sequences (SSSS) or specificity determining positions (SDPs) in MIPs transporting non-aqua substrates.
Takahiro Ishikawa (639481), Abul Kalam Azad (3165174), Md. Mahbub Hasan (3165168), Maki Katsuhara (3165165), Jahed Ahmed (3165171), Md. Asraful Alum (3165177), Yoshihiro Sawa (3165162)   +6 more
core   +1 more source