Results 81 to 90 of about 5,430,598 (303)

Effect of substrate temperature on structure, magnetic and electrical transport properties of Mn1.60Ga films

Materials Research Express, 2020
L 1 _0 -MnGa alloys have great application potential in the fields of permanent magnet and spintronics. L 1 _0 -Mn _1.60 Ga thin films were prepared on MgO (100) substrates by magnetron sputtering under different substrate temperatures ranging from 200 ...
Yumei Zhang, Chaoqun Yang, Li Wang, Yidan Bai, Sitong Liu, Haibo Li   +5 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

An evaluation of cellulose as a substrate for room-temperature phosphorescence

Talanta, 1982
Cotton-linter pulps, wood pulps and several filter papers have been evaluated as substrates for room-temperature phosphorescence. A variety of chemical treatments of one filter paper is discussed in terms of reducing the background phosphorescence of the cellulose and in evaluating possible trace contaminants in cotton fibres.
Department of Chemistry, University of Florida, Gainesville, FL 32611, U.S.A. ( host institution ), Bateh, R.P. ( author ), Winefordner, J.D. ( author )   +2 more
openaire   +3 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Effect of Substrate Temperature on the Morphology and Crystallinity of TiO₂ Thin Films Grown by ALD Using TTIP and H₂O

East European Journal of Physics
This study investigates the influence of substrate temperature on the morphological and structural characteristics of TiO2 thin films synthesized by thermal ALD using titanium tetraisopropoxide and water as precursors.
Temur K. Turdaliev, Khojiakhmad Kh. Zokhidov, Shukhrat Ch. Iskandarov, Usmonjon F. Berdiyev   +3 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Analysis of Loaded Substrate Integrated Waveguides and Attenuators [PDF]

, 2013
This letter provides an approximate analysis of a slotted substrate integrated waveguide with periodic loading elements using the transverse resonance technique.
Xu, Ruo Feng, Farrall, A.J., Young, Paul R.   +2 more
core   +1 more source

Effects of Substrate Temperature on Vacuum Deposited Thin Film of Disperse Red 1 on ITO Glass

Journal of Mathematical and Fundamental Sciences, 2019
. Highly crystalline thin films of photorefractive Disperse Red 1 (DR 1) molecule have been fabricated on clean substrate of ITO (indium tin oxide) glass by means of physical vapor deposition at various substrate temperatures.
H. Taunaumang, Herman Herman, M. O. Tjia
doaj