Results 21 to 30 of about 488,438 (323)

Anatomy and Connectivity of the Subthalamic Nucleus in Humans and Non-human Primates

Frontiers in Neuroanatomy, 2020
The Subthalamic Nucleus (STh) is an oval-shaped diencephalic structure located ventrally to the thalamus, playing a fundamental role in the circuitry of the basal ganglia.
A. Emmi, A. Antonini, V. Macchi, A. Porzionato, R. De Caro   +4 more
semanticscholar   +1 more source

Levodopa responsiveness and white matter alterations in Parkinson's disease: A DTI‐based study and brain network analysis: A cross‐sectional study

Brain and Behavior, Volume 12, Issue 12, December 2022., 2022
Abstract Background Patients with Parkinson's disease (PD) present various responsiveness to levodopa, but the cause of such differences in levodopa responsiveness is unclear. Previous studies related the damage of brain white matter (WM) to levodopa responsiveness in PD patients, but no study investigated the relationship between the structural brain ...
Juncong Du, Xuan Zhou, Yi Liang, Lili Zhao, Chengcheng Dai, Yuke Zhong, Hang Liu, Guohui Liu, Lijuan Mo, Changhong Tan, Xi Liu, Lifen Chen   +11 more
wiley   +1 more source

Impact of deep brain stimulation of the subthalamic nucleus on natural language in patients with Parkinson's disease.

PLoS ONE, 2020
BackgroundIn addition to the typical motor symptoms, a majority of patients suffering from Parkinson's disease experience language impairments. Deep Brain Stimulation of the subthalamic nucleus robustly reduces motor dysfunction, but its impact on ...
Felicitas Ehlen, Bassam Al-Fatly, Andrea A Kühn, Fabian Klostermann   +3 more
doaj   +1 more source

Aversion encoded in the subthalamic nucleus [PDF]

, 2020
AbstractActivation of the subthalamic nucleus (STN) is associated with the stopping of ongoing behavior via the basal ganglia. However, we recently observed that optogenetic STN excitation induced a strong jumping/escaping behavior. We hypothesized that STN activation is aversive. To test this, place preference was assessed.
Gian Pietro Serra, Åsa Wallén-Mackenzie, François Georges, François Georges, Jérôme Baufreton, Jérôme Baufreton, Adriane Guillaumin   +6 more
openaire   +3 more sources

Spatio-molecular domains identified in the mouse subthalamic nucleus and neighboring glutamatergic and GABAergic brain structures

Communications Biology, 2020
The subthalamic nucleus (STN) is crucial for normal motor, limbic and associative function. STN dysregulation is correlated with several brain disorders, including Parkinsonʼs disease and obsessive compulsive disorder (OCD), for which high-frequency ...
Å. Wallén-Mackenzie, S. Dumas, Maria Papathanou, Mihaela M. Martis Thiele, Bianca Vlcek, N. König, Åsa K. Björklund   +6 more
semanticscholar   +1 more source

The role of the subthalamic nucleus in cognition [PDF]

Reviews in the Neurosciences, 2013
Because the complex functions of the basal ganglia have been increasingly studied over the past several decades, the understanding of the role of the subthalamic nucleus (STN) in motor and cognitive functions has evolved. The traditional role in motor function ascribed to the STN, based on its involvement in the cortico-striato-thalamo-cortical motor ...
Kareem A. Zaghloul, David B. Weintraub
openaire   +2 more sources

Subthalamic Nucleus Stimulation Impairs Motivation: Implication for Apathy in Parkinson's Disease

Movement Disorders, 2020
Apathy is one of the most disabling neuropsychiatric symptoms in Parkinson's disease (PD) patients and has a higher prevalence in patients under subthalamic nucleus deep brain stimulation.
Yvan M. Vachez, C. Carcenac, Robin Magnard, L. Kerkerian-Le Goff, P. Salin, M. Savasta, S. Carnicella, S. Boulet   +7 more
semanticscholar   +1 more source

Topography and distribution of adenosine A2A and dopamine D2 receptors in the human Subthalamic Nucleus

Frontiers in Neuroscience, 2022
The human Subthalamic Nucleus (STh) is a diencephalic lens-shaped structure located ventrally to the thalamus and functionally implicated in the basal ganglia circuits.
Aron Emmi, Aron Emmi, Aron Emmi, Angelo Antonini, Angelo Antonini, Michele Sandre, Michele Sandre, Andrea Baldo, Martina Contran, Veronica Macchi, Veronica Macchi, Diego Guidolin, Andrea Porzionato, Andrea Porzionato, Raffaele De Caro, Raffaele De Caro   +15 more
doaj   +1 more source

Subthalamic Nucleus

Definitions, 2020
The paired, biconvex cluster of neurons located under the thalamus that plays a major role in the motor cortico-basal ganglia-thalamo-cortical circuit. The subthalamic nucleus is primary involved in the control of voluntary movement.

semanticscholar   +1 more source

The subthalamic nucleus becomes a generator of bursts in the dopamine-depleted state. Its high frequency stimulation dramatically weakens transmission to the globus pallidus

Frontiers in Systems Neuroscience, 2011
Excessive burst firing in the dopamine-depleted basal ganglia correlates with severe motor symptoms of Parkinson’s disease that are attenuated by high frequency electrical stimulation of the subthalamic nucleus.
Rachida eAmmari, Rachida eAmmari, Bernard eBioulac, Liliana eGarcia, Constance eHammond   +4 more
doaj   +1 more source