Results 21 to 30 of about 490,910 (294)
Neural Regeneration Research, 2023 There are many documented sex differences in the clinical course, symptom expression profile, and treatment response of Parkinson’s disease, creating additional challenges for patient management.
Tian-Shuo Yuan +7 more
doaj +1 more source
Mathematical model of subthalamic nucleus neuron: characteristic activity patterns and bifurcation analysis [PDF]
Chaos 31, 113121 (2021), 2021 The subthalamic nucleus (STN) has an important role in the pathophysiology of the basal ganglia in Parkinson's disease. The ability of STN cells to generate bursting rhythms under either transient or sustained hyperpolarization may underlie the excessively synchronous beta rhythms observed in Parkinson's disease.
arxiv +1 more source
Neural Regeneration Research, 2021 Deep brain stimulation of the bilateral subthalamic nucleus (STN) is a therapeutic option for patients with Parkinson’s disease (PD) in whom medical therapies have been ineffective.
Guo-Xiong Cheng +6 more
doaj +1 more source
Deep brain stimulation electrode position impact on parkinsonian non-motor symptoms
Biomedical Papers, 2022 Background. In this study we evaluated the impact of location of deep brain stimulation electrode active contact in different parts of the subthalamic nucleus on improvement of non-motor symptoms in patients with Parkinson's disease. Methods.
Jan Bardon +15 more
doaj +1 more source
Journal of Contemporary Medicine, 2023 Background: Although the subtahalamic nucleus degeneration has been accused of Parkinson’s disease, the obscure roles of subtalamic nucleus degeneration induced by subarachnoid hemorrhages has not been adequately studied.
Mehmet Hakan Şahin, Mete Zeynal
doaj +1 more source
Anatomy and Connectivity of the Subthalamic Nucleus in Humans and Non-human Primates
Frontiers in Neuroanatomy, 2020 The Subthalamic Nucleus (STh) is an oval-shaped diencephalic structure located ventrally to the thalamus, playing a fundamental role in the circuitry of the basal ganglia.
A. Emmi +4 more
semanticscholar +1 more source
Subthalamic Nucleus Deep Brain Stimulation Modulates 2 Distinct Neurocircuits
Annals of Neurology, 2020 Current understanding of the neuromodulatory effects of deep brain stimulation (DBS) on large‐scale brain networks remains elusive, largely due to the lack of techniques that can reveal DBS‐induced activity at the whole‐brain level.
Lunhao Shen +13 more
semanticscholar +1 more source
PLoS ONE, 2020 BackgroundIn addition to the typical motor symptoms, a majority of patients suffering from Parkinson's disease experience language impairments. Deep Brain Stimulation of the subthalamic nucleus robustly reduces motor dysfunction, but its impact on ...
Felicitas Ehlen +3 more
doaj +1 more source
Communications Biology, 2020 The subthalamic nucleus (STN) is crucial for normal motor, limbic and associative function. STN dysregulation is correlated with several brain disorders, including Parkinsonʼs disease and obsessive compulsive disorder (OCD), for which high-frequency ...
Å. Wallén-Mackenzie +6 more
semanticscholar +1 more source
Subthalamic Nucleus Stimulation Impairs Motivation: Implication for Apathy in Parkinson's Disease
Movement Disorders, 2020 Apathy is one of the most disabling neuropsychiatric symptoms in Parkinson's disease (PD) patients and has a higher prevalence in patients under subthalamic nucleus deep brain stimulation.
Yvan M. Vachez +7 more
semanticscholar +1 more source