Results 21 to 30 of about 502,362 (345)

Dysconnectivity of the parafascicular nucleus in Parkinson's disease: A dynamic causal modeling analysis

Neurobiology of Disease, 2023
Background: Recent animal model studies have suggested that the parafascicular nucleus has the potential to be an effective deep brain stimulation target for Parkinson's disease.
Lili Chen, Junyan Sun, Linlin Gao, Junling Wang, Jinghong Ma, Erhe Xu, Dongling Zhang, Liang Li, Tao Wu   +8 more
doaj   +1 more source

Potential mechanisms for imperfect synchronization in parkinsonian basal ganglia [PDF]

, 2012
Neural activity in the brain of parkinsonian patients is characterized by the intermittently synchronized oscillatory dynamics. This imperfect synchronization, observed in the beta frequency band, is believed to be related to the hypokinetic motor ...
Park, Choongseok, Rubchinsky, Leonid
core   +6 more sources

Impact of deep brain stimulation of the subthalamic nucleus on natural language in patients with Parkinson's disease.

PLoS ONE, 2020
BackgroundIn addition to the typical motor symptoms, a majority of patients suffering from Parkinson's disease experience language impairments. Deep Brain Stimulation of the subthalamic nucleus robustly reduces motor dysfunction, but its impact on ...
Felicitas Ehlen, Bassam Al-Fatly, Andrea A Kühn, Fabian Klostermann   +3 more
doaj   +1 more source

Subthalamic Nucleus Deep Brain Stimulation Modulates 2 Distinct Neurocircuits

Annals of Neurology, 2020
Current understanding of the neuromodulatory effects of deep brain stimulation (DBS) on large‐scale brain networks remains elusive, largely due to the lack of techniques that can reveal DBS‐induced activity at the whole‐brain level.
Lunhao Shen, Changqing Jiang, C. S. Hubbard, Jianxun Ren, Changgeng He, Danhong Wang, L. Dahmani, Yi Guo, Yiming Liu, Shujun Xu, F. Meng, Jianguo Zhang, Hesheng Liu, Luming Li   +13 more
semanticscholar   +1 more source

Subacute alpha frequency (10Hz) subthalamic stimulation for emotional processing in Parkinson's disease

Brain Stimulation, 2023
Background: Psychiatric comorbidities are common in Parkinson's disease (PD) and may change with high-frequency stimulation targeting the subthalamic nucleus.
Linbin Wang, Jun Li, Yixin Pan, Peng Huang, Dianyou Li, Valerie Voon   +5 more
doaj   +1 more source

Anatomy and Connectivity of the Subthalamic Nucleus in Humans and Non-human Primates

Frontiers in Neuroanatomy, 2020
The Subthalamic Nucleus (STh) is an oval-shaped diencephalic structure located ventrally to the thalamus, playing a fundamental role in the circuitry of the basal ganglia.
A. Emmi, A. Antonini, V. Macchi, A. Porzionato, R. De Caro   +4 more
semanticscholar   +1 more source

Spatio-molecular domains identified in the mouse subthalamic nucleus and neighboring glutamatergic and GABAergic brain structures

Communications Biology, 2020
The subthalamic nucleus (STN) is crucial for normal motor, limbic and associative function. STN dysregulation is correlated with several brain disorders, including Parkinsonʼs disease and obsessive compulsive disorder (OCD), for which high-frequency ...
Å. Wallén-Mackenzie, S. Dumas, Maria Papathanou, Mihaela M. Martis Thiele, Bianca Vlcek, N. König, Åsa K. Björklund   +6 more
semanticscholar   +1 more source

Parkinsonian Beta Dynamics during Rest and Movement in the Dorsal Pallidum and Subthalamic Nucleus

Journal of Neuroscience, 2020
In Parkinson's disease (PD), pathologically high levels of beta activity (12–30 Hz) reflect specific symptomatology and normalize with pharmacological or surgical intervention.
R. Eisinger, Jackson N. Cagle, E. Opri, Jose Alcantara, Stephanie Cernera, K. Foote, M. Okun, A. Gunduz   +7 more
semanticscholar   +1 more source

Topography and distribution of adenosine A2A and dopamine D2 receptors in the human Subthalamic Nucleus

Frontiers in Neuroscience, 2022
The human Subthalamic Nucleus (STh) is a diencephalic lens-shaped structure located ventrally to the thalamus and functionally implicated in the basal ganglia circuits.
Aron Emmi, Aron Emmi, Aron Emmi, Angelo Antonini, Angelo Antonini, Michele Sandre, Michele Sandre, Andrea Baldo, Martina Contran, Veronica Macchi, Veronica Macchi, Diego Guidolin, Andrea Porzionato, Andrea Porzionato, Raffaele De Caro, Raffaele De Caro   +15 more
doaj   +1 more source

The subthalamic nucleus becomes a generator of bursts in the dopamine-depleted state. Its high frequency stimulation dramatically weakens transmission to the globus pallidus

Frontiers in Systems Neuroscience, 2011
Excessive burst firing in the dopamine-depleted basal ganglia correlates with severe motor symptoms of Parkinson’s disease that are attenuated by high frequency electrical stimulation of the subthalamic nucleus.
Rachida eAmmari, Rachida eAmmari, Bernard eBioulac, Liliana eGarcia, Constance eHammond   +4 more
doaj   +1 more source