Results 31 to 40 of about 17,967 (218)

Sweetspot Mapping in Deep Brain Stimulation: Strengths and Limitations of Current Approaches

Neuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Objectives Open questions remain regarding the optimal target, or sweetspot, for deep brain stimulation (DBS) in, for example, Parkinson's disease. Previous studies introduced different methods of mapping DBS effects to determine sweetspots. While having a direct impact on surgical targeting and postoperative programming in DBS, these methods ...
Till A. Dembek, Juan Carlos Baldermann, Jan‐Niklas Petry‐Schmelzer, Hannah Jergas, Harald Treuer, Veerle Visser‐Vandewalle, Haidar S. Dafsari, Michael T. Barbe   +7 more
wiley   +1 more source

Is Deep Brain Stimulation a viable treatment for substance-related addiction? [PDF]

Romanian Journal of Neurology, 2019
For the ability to modulate the activity of dysregulated networks Deep Brain Stimulation (DBS) of areas involved in reward system and motivational states may have a potential application in addiction despite risks associated with its invasiveness.
Giusy Guzzi, Angelo Lavano, Serena Marianna Lavano, Rosa Marotta   +3 more
doaj   +1 more source

Motor Evoked Potentials Improve Targeting in Deep Brain Stimulation Surgery

Neuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Objectives One of the main challenges posed by the surgical deep brain stimulation (DBS) procedure is the successful targeting of the structures of interest and avoidance of side effects, especially in asleep surgery. Here, intraoperative motor evoked potentials (MEPs) might serve as tool to identify the pyramidal tract.
Petyo Nikolov, Verena Heil, Christian J. Hartmann, Nikola Ivanov, Philipp J. Slotty, Jan Vesper, Alfons Schnitzler, Stefan Jun Groiss   +7 more
wiley   +1 more source

Dopamine Dysregulation Syndrome and Deep Brain Stimulation of the Subthalamic Nucleus in Parkinson's Disease

Neurology Research International, 2011
Dopamine dysregulation syndrome is a complication of the dopaminergic treatment in Parkinson's disease that may be very disabling due to the negative impact that compulsive medication use may have on patients' social, psychological, and physical ...
Beatriz De la Casa-Fages, Francisco Grandas   +1 more
doaj   +1 more source

The subthalamic nucleus in the context of movement disorders [PDF]

Brain, 2004
The subthalamic nucleus (STN) has been regarded as an important modulator of basal ganglia output. It receives its major afferents from the cerebral cortex, thalamus, globus pallidus externus and brainstem, and projects mainly to both segments of the globus pallidus, substantia nigra, striatum and brainstem.
Clement, Hamani, Jean A, Saint-Cyr, Justin, Fraser, Michael, Kaplitt, Andres M, Lozano   +4 more
openaire   +2 more sources

Remote Magnetomechanical Neuromodulation Uncovers Therapeutic Mechanisms for Alleviating Parkinsonian Symptoms in Freely Moving Mice

Advanced Science, EarlyView.
Magnetomechanical neuromodulation using magnetic nanodiscs enables remote activation of neurons. In a hemiparkinsonian mouse model, alternating magnetic fields actuate the nanodiscs to generate torque that opens mechanosensitive ion channels within the subthalamic nucleus, thereby modulating basal ganglia motor circuitry.
Anouk Wolters, Lorenzo Signorelli, Christian Herff, Sophia Gimple, Renzo Riemens, Gunter Kenis, Kim Rijkers, Hamed Shabani, Jyh‐Jang Sun, Yasin Temel, Hans Clusmann, Danijela Gregurec, Sarah‐Anna Hescham   +12 more
wiley   +1 more source

Directional Deep Brain Stimulation for Parkinson's Disease: Results of an International Crossover Study With Randomized, Double‐Blind Primary Endpoint

Neuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Objective Published reports on directional deep brain stimulation (DBS) have been limited to small, single‐center investigations. Therapeutic window (TW) is used to describe the range of stimulation amplitudes achieving symptom relief without side effects.
Alfons Schnitzler, Pablo Mir, Matthew A. Brodsky, Leonard Verhagen, Sergiu Groppa, Ramiro Alvarez, Andrew Evans, Marta Blazquez, Sean Nagel, Julie G. Pilitsis, Monika Pötter‐Nerger, Winona Tse, Leonardo Almeida, Nestor Tomycz, Joohi Jimenez‐Shahed, Witold Libionka, Fatima Carrillo, Christian J. Hartmann, Stefan Jun Groiss, Martin Glaser, Florence Defresne, Edward Karst, Binith Cheeran, Jan Vesper, for the PROGRESS Study Investigators   +24 more
wiley   +1 more source

Cortico-basal white matter alterations occurring in Parkinson's disease.

PLoS ONE, 2019
Magnetic resonance imaging studies typically use standard anatomical atlases for identification and analyses of (patho-)physiological effects on specific brain areas; these atlases often fail to incorporate neuroanatomical alterations that may occur with
Bethany R Isaacs, Anne C Trutti, Esther Pelzer, Marc Tittgemeyer, Yasin Temel, Birte U Forstmann, Max C Keuken   +6 more
doaj   +1 more source

Chaotic desynchronization as the therapeutic mechanism of deep brain stimulation

Frontiers in Systems Neuroscience, 2011
High frequency deep-brain stimulation of the subthalamic nucleus (DBS) relieves many of the symptoms of Parkinson's disease in humans and animal models. Although the treatment has seen widespread use, its therapeutic mechanism remains paradoxical. The
Charles J Wilson, Bryce eBeverlin, Theoden I Netoff   +2 more
doaj   +1 more source

The next step for imaging the subthalamic nucleus [PDF]

Brain, 2016
Sir, We read with interest the recently published study by Accolla and colleagues (2016) on brain networks modulated by subthalamic nucleus deep brain stimulation (DBS; Accolla et al. , 2016). In their study, the authors combined neurophysiological recordings with MRI to obtain much needed, more detailed information on the functional organization of ...
Forstmann, B.U., Keuken, M.C., Alkemade, A.   +2 more
openaire   +5 more sources