Results 41 to 50 of about 351,721 (248)

Sweetspot Mapping in Deep Brain Stimulation: Strengths and Limitations of Current Approaches

Neuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Objectives Open questions remain regarding the optimal target, or sweetspot, for deep brain stimulation (DBS) in, for example, Parkinson's disease. Previous studies introduced different methods of mapping DBS effects to determine sweetspots. While having a direct impact on surgical targeting and postoperative programming in DBS, these methods ...
Till A. Dembek, Juan Carlos Baldermann, Jan‐Niklas Petry‐Schmelzer, Hannah Jergas, Harald Treuer, Veerle Visser‐Vandewalle, Haidar S. Dafsari, Michael T. Barbe   +7 more
wiley   +1 more source

A role for the subthalamic nucleus in aversive learning

Cell Reports, 2023
The subthalamic nucleus (STN) is critical for behavioral control; its dysregulation consequently correlated with neurological and neuropsychiatric disorders, including Parkinson's disease. Deep brain stimulation (DBS) targeting the STN successfully alleviates parkinsonian motor symptoms. However, low mood and depression are affective side effects.
Serra, Gian Pietro, Guillaumin, Adriane, Vlcek, Bianca, Delgado-Zabalza, Lorena, Ricci, Alessia, Rubino, Eleonora, Dumas, Sylvie, Baufreton, Jérôme, Georges, François, Wallén-Mackenzie, Åsa   +9 more
openaire   +7 more sources

Motor Evoked Potentials Improve Targeting in Deep Brain Stimulation Surgery

Neuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Objectives One of the main challenges posed by the surgical deep brain stimulation (DBS) procedure is the successful targeting of the structures of interest and avoidance of side effects, especially in asleep surgery. Here, intraoperative motor evoked potentials (MEPs) might serve as tool to identify the pyramidal tract.
Petyo Nikolov, Verena Heil, Christian J. Hartmann, Nikola Ivanov, Philipp J. Slotty, Jan Vesper, Alfons Schnitzler, Stefan Jun Groiss   +7 more
wiley   +1 more source

In Parkinson’s disease dopaminergic medication and deep brain stimulation of the subthalamic nucleus increase motor, but not reflection and cognitive impulsivity

Frontiers in Neuroscience
BackgroundParkinson’s disease is associated with increased impulsivity, which can be divided into several domains: motor (consisting of proactive and reactive subdomains), reflection, and cognitive impulsivity.
Martijn Hendriks, Martijn Hendriks, Saman Vinke, Rok Berlot, Rok Berlot, Mitja Benedičič, Marjan Jahansahi, Maja Trošt, Maja Trošt, Dejan Georgiev, Dejan Georgiev   +10 more
doaj   +1 more source

Directional Deep Brain Stimulation for Parkinson's Disease: Results of an International Crossover Study With Randomized, Double‐Blind Primary Endpoint

Neuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Objective Published reports on directional deep brain stimulation (DBS) have been limited to small, single‐center investigations. Therapeutic window (TW) is used to describe the range of stimulation amplitudes achieving symptom relief without side effects.
Alfons Schnitzler, Pablo Mir, Matthew A. Brodsky, Leonard Verhagen, Sergiu Groppa, Ramiro Alvarez, Andrew Evans, Marta Blazquez, Sean Nagel, Julie G. Pilitsis, Monika Pötter‐Nerger, Winona Tse, Leonardo Almeida, Nestor Tomycz, Joohi Jimenez‐Shahed, Witold Libionka, Fatima Carrillo, Christian J. Hartmann, Stefan Jun Groiss, Martin Glaser, Florence Defresne, Edward Karst, Binith Cheeran, Jan Vesper, for the PROGRESS Study Investigators   +24 more
wiley   +1 more source

Deep Brain Stimulation Reduces Conflict‐Related Theta and Error‐Related Negativity in Patients With Obsessive–Compulsive Disorder

Neuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Objectives Obsessive–compulsive disorder (OCD) is a psychiatric disorder with alterations of cortico‐striato‐thalamo‐cortical loops and impaired performance monitoring. Electrophysiological markers such as conflict‐related medial frontal theta (MFT) and error‐related negativity (ERN) may be altered by clinically effective deep brain ...
Elena Sildatke, Theo O. J. Gruendler, Markus Ullsperger, Till A. Dembek, Juan Carlos Baldermann, Sina Kohl, Veerle Visser‐Vandewalle, Daniel Huys, Jens Kuhn, Thomas Schüller   +9 more
wiley   +1 more source

Analysis of local field potentials from the human subthalamic nucleus

, 2022
This paper reviews and discusses the experimental protocol, the data analysis methods, and the principal results our group obtained in the study of local field potentials from the human subthalamic nucleus in patients affected by Parkinson's ...
Bianchi, AM, Cerutti, S, Priori, A, Foffani, G, Croci, S, Baselli, G   +5 more
core   +1 more source

Nomogram for Predicting Depression Improvement after Deep Brain Stimulation for Parkinson’s Disease

Brain Sciences, 2022
Background: Parkinson’s disease is a common neurodegenerative disease, with depression being a common non-motor symptom. Bilateral subthalamic nucleus deep brain stimulation is an effective method for the treatment of Parkinson’s disease.
Bowen Chang, Chen Ni, Jiaming Mei, Chi Xiong, Peng Chen, Manli Jiang, Chaoshi Niu   +6 more
doaj   +1 more source

Deep Brain Stimulation of Caudal Zona Incerta for Parkinson's Disease: One‐Year Follow‐Up and Electric Field Simulations

Neuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Objective To evaluate the effects of bilateral caudal zona incerta (cZi) deep brain stimulation (DBS) for Parkinson's disease (PD) one year after surgery and to create anatomical improvement maps based on patient‐specific simulation of the electric field.
Rasmus Stenmark Persson, Teresa Nordin, Gun‐Marie Hariz, Karin Wårdell, Lars Forsgren, Marwan Hariz, Patric Blomstedt   +6 more
wiley   +1 more source

Dopamine Dysregulation Syndrome and Deep Brain Stimulation of the Subthalamic Nucleus in Parkinson's Disease

Neurology Research International, 2011
Dopamine dysregulation syndrome is a complication of the dopaminergic treatment in Parkinson's disease that may be very disabling due to the negative impact that compulsive medication use may have on patients' social, psychological, and physical ...
Beatriz De la Casa-Fages, Francisco Grandas   +1 more
doaj   +1 more source