Results 51 to 60 of about 351,721 (248)

The next step for imaging the subthalamic nucleus [PDF]

Brain, 2016
Sir, We read with interest the recently published study by Accolla and colleagues (2016) on brain networks modulated by subthalamic nucleus deep brain stimulation (DBS; Accolla et al. , 2016). In their study, the authors combined neurophysiological recordings with MRI to obtain much needed, more detailed information on the functional organization of ...
Forstmann, B.U., Keuken, M.C., Alkemade, A.   +2 more
openaire   +5 more sources

Local Field Potential‐Based Programming: A Proof‐of‐Concept Pilot Study

Neuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Objectives Programming deep brain stimulation (DBS) is still based on a trial‐and‐error approach, often becoming a time‐consuming process for both treating physicians and patients. Several strategies have been proposed to streamline DBS programming, most of which are preliminary and mainly address Parkinson's disease, a condition readily ...
Alfonso Fasano, Carolina Gorodetsky, Darcia Paul, Jürgen Germann, Aaron Loh, Han Yan, Peter L. Carlen, Sara Breitbart, Andres M. Lozano, George M. Ibrahim, Suneil K. Kalia   +10 more
wiley   +1 more source

Supplementary Materials for Optimization of an anatomically and electrically detailed subthalamic nucleus neuron model

, 2023
This is the supplementary materials for journal article Optimization of an anatomically and electrically detailed subthalamic nucleus neuron ...
Cameron C. McIntyre (294148), M. Sohail Noor (17457645), Clayton S. Bingham (5564354), Hengji Chen (17616819)   +3 more
core   +1 more source

Is Deep Brain Stimulation a viable treatment for substance-related addiction? [PDF]

Romanian Journal of Neurology, 2019
For the ability to modulate the activity of dysregulated networks Deep Brain Stimulation (DBS) of areas involved in reward system and motivational states may have a potential application in addiction despite risks associated with its invasiveness.
Giusy Guzzi, Angelo Lavano, Serena Marianna Lavano, Rosa Marotta   +3 more
doaj   +1 more source

Subdivisions and Anatomical Boundaries of the Subthalamic Nucleus [PDF]

The Journal of Neuroscience, 2013
The subthalamic nucleus (STN) lies deep within the brain and plays a central role in both the direct and indirect pathway of the basal ganglia ([Temel et al., 2005][1]). The nucleus itself does not degenerate in patients with Parkinson's disease, but it is an important target for deep ...
openaire   +4 more sources

Remote Magnetomechanical Neuromodulation Uncovers Therapeutic Mechanisms for Alleviating Parkinsonian Symptoms in Freely Moving Mice

Advanced Science, EarlyView.
Magnetomechanical neuromodulation using magnetic nanodiscs enables remote activation of neurons. In a hemiparkinsonian mouse model, alternating magnetic fields actuate the nanodiscs to generate torque that opens mechanosensitive ion channels within the subthalamic nucleus, thereby modulating basal ganglia motor circuitry.
Anouk Wolters, Lorenzo Signorelli, Christian Herff, Sophia Gimple, Renzo Riemens, Gunter Kenis, Kim Rijkers, Hamed Shabani, Jyh‐Jang Sun, Yasin Temel, Hans Clusmann, Danijela Gregurec, Sarah‐Anna Hescham   +12 more
wiley   +1 more source

The Intraoperative Microlesion Effect Positively Correlates With the Short‐Term Clinical Effect of Deep Brain Stimulation in Parkinson's Disease

Neuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Objective During the surgical procedure of deep brain stimulation (DBS), insertion of an electrode in the subthalamic nucleus (STN) frequently causes a temporary improvement of motor symptoms, known as the microlesion effect (MLE). The objective of this study was to determine the correlation between the intraoperative MLE and the clinical ...
Stèfan F. Lange, Naomi I. Kremer, Teus van Laar, Fiete Lange, T. Elien Steendam‐Oldekamp, D. L. Marinus Oterdoom, Anthony R. Absalom, J. Marc C. van Dijk, Gea Drost   +8 more
wiley   +1 more source

Cortico-basal white matter alterations occurring in Parkinson's disease.

PLoS ONE, 2019
Magnetic resonance imaging studies typically use standard anatomical atlases for identification and analyses of (patho-)physiological effects on specific brain areas; these atlases often fail to incorporate neuroanatomical alterations that may occur with
Bethany R Isaacs, Anne C Trutti, Esther Pelzer, Marc Tittgemeyer, Yasin Temel, Birte U Forstmann, Max C Keuken   +6 more
doaj   +1 more source

Chaotic desynchronization as the therapeutic mechanism of deep brain stimulation

Frontiers in Systems Neuroscience, 2011
High frequency deep-brain stimulation of the subthalamic nucleus (DBS) relieves many of the symptoms of Parkinson's disease in humans and animal models. Although the treatment has seen widespread use, its therapeutic mechanism remains paradoxical. The
Charles J Wilson, Bryce eBeverlin, Theoden I Netoff   +2 more
doaj   +1 more source

The subthalamic nucleus in the context of movement disorders [PDF]

Brain, 2004
The subthalamic nucleus (STN) has been regarded as an important modulator of basal ganglia output. It receives its major afferents from the cerebral cortex, thalamus, globus pallidus externus and brainstem, and projects mainly to both segments of the globus pallidus, substantia nigra, striatum and brainstem.
Clement, Hamani, Jean A, Saint-Cyr, Justin, Fraser, Michael, Kaplitt, Andres M, Lozano   +4 more
openaire   +2 more sources