Results 51 to 60 of about 38,228 (259)
NeuroImage: Clinical, 2018 Deep brain stimulation of the subthalamic nucleus for Parkinson's disease is an established advanced therapy that addresses motor symptoms and improves quality of life.
Philip E. Mosley +5 more
doaj +1 more source
Modeling effect of GABAergic current in a basal ganglia computational model
, 2012 Electrical high frequency stimulation (HFS) of deep brain regions is a method shown to be clinically effective in different types of movement and neurological disorders.
Claussen, Jens Christian +3 more
core +1 more source
Numerical characterization of intraoperative and chronic electrodes in deep brain stimulation [PDF]
, 2015 An intraoperative electrode (microelectrode) is used in the deep bra In stImulation (DBS) technique to pinpoint the brain target and to choose the best parameters for the electrical stimulus.
Apollonio, Francesca +4 more
core +2 more sources
Advanced Science, EarlyView.Magnetomechanical neuromodulation using magnetic nanodiscs enables remote activation of neurons. In a hemiparkinsonian mouse model, alternating magnetic fields actuate the nanodiscs to generate torque that opens mechanosensitive ion channels within the subthalamic nucleus, thereby modulating basal ganglia motor circuitry.
Anouk Wolters +12 more
wiley +1 more source
Posterior subthalamic nucleus (PSTh) mediates innate fear-associated hypothermia in mice
Nature Communications, 2021 Innate and learned fear can induce rapid changes in body temperature of mammals. The authors identify the posterior subthalamic nucleus as a major thermoregulatory hub that connects the external lateral parabrachial subnucleus to the nucleus of the ...
Can Liu +9 more
doaj +1 more source
, 2014 The basal ganglia nuclei form a complex network of nuclei often assumed to perform selection, yet their individual roles and how they influence each other is still largely unclear.
Girard, Benoît, Liénard, Jean
core +4 more sources
Sono‐Mechanogenetics: Linking Ultrasound Physics With Cellular Mechanobiology
Advanced Science, EarlyView.Sono‐mechanogenetics links ultrasound physics with cellular mechanotransduction to enable noninvasive control of engineered biological systems. Acoustic forces generate distinct deformation modes that activate intracellular signaling pathways, which can be coupled to synthetic gene circuits to regulate diverse cellular functions, including gene ...
Yunjia Qu +4 more
wiley +1 more source
Subdivisions and Anatomical Boundaries of the Subthalamic Nucleus [PDF]
The Journal of Neuroscience, 2013 The subthalamic nucleus (STN) lies deep within the brain and plays a central role in both the direct and indirect pathway of the basal ganglia ([Temel et al., 2005][1]). The nucleus itself does not degenerate in patients with Parkinson's disease, but it is an important target for deep ...
openaire +4 more sources
Transcriptional Profile of the Developing Subthalamic Nucleus
eneuro, 2022 AbstractThe subthalamic nucleus (STN) is a small, excitatory nucleus that regulates the output of basal ganglia motor circuits. The functions of the STN and its role in the pathophysiology of Parkinson’s disease are now well established. However, some basic characteristics like the developmental origin and molecular phenotype of neuronal subpopulations
Ema Bokulić +2 more
openaire +4 more sources
Multimodal Image Guidance in Subthalamic Deep Brain Stimulation for Parkinson's Disease
Annals of Neurology, EarlyView.Objective Accurate electrode placement and individual stimulation parameters influence the outcomes of subthalamic deep brain stimulation in Parkinson's disease. Neuroimaging‐based models can help evaluate how electrode placement impacts improvement, aiming to reduce the burden of programming.
Patricia Zvarova +27 more
wiley +1 more source